Search Results - stem+cells+and+regenerative+medicine

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Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration

Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration Overview During a heart attack it is estimated that 1 billion cardiomyocytes (i.e. heart muscle cells) are killed. Unlike other organs in the body, the heart has a limited capacity to regenerate. This means that the cardiomyocytes lost during a heart attack are replaced...

Published: 11/25/2024 | Inventor(s): Kareen Coulombe, Kiera Dwyer, Rajeev Kant

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine

Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model

Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model Overview The extracellular matrix (ECM) of the body is the network of proteins and other molecules that surrounds cells and tissues. The ECM is directly involved in a variety of essential cellular processes including structural support,...

Published: 11/25/2024 | Inventor(s): Jeffrey Morgan, Benjamin Wilks

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine, Research Tools, Drug Discovery Platform

Mid-scale vessels in engineered tissue for regeneration

Overview Vascularization is a primary concern when developing implantable cardiac tissues, as it is critical for superior engraftment and integration. We have developed a method for engineering a vascular supply for engineered human myocardium to ensure tissue survival and engraftment upon implantation and improve therapeutic efficacy. Market Opportunity Myocardial...

Published: 8/22/2024 | Inventor(s): Kareen Coulombe, Rajeev Kant, Kiera Dwyer

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine

Novel proangiogenic cocktails of growth factors and cytokines to revascularize ischemic tissue

Overview Revascularization of ischemic tissue can be achieved using growth factors to recapitulate native developmental and wound healing cascades, and stimulate angiogenesis and arteriogenesis. These pro-vasculogenic growth factor cocktails can also increase the efficacy and translatability of regenerative therapeutics for clinical uses. We have developed...

Published: 6/4/2023 | Inventor(s): Kareen Coulombe, Alicia Minor

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine

Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmogenic Toxicity Responses

Overview To guide the development of atrial-specific drugs and evaluate their safety, there is a need for in vitro models to accurately assess the cardiotoxic effects of novel therapeutics in both atrial and ventricular cell populations, with high throughput. We have developed a robust in vitro 3D atrial tissue platform made from human-induced pluripotent...

Published: 6/4/2023 | Inventor(s): Kareen Coulombe, Bum-Rak Choi, Tae Yun Kim, Mark Daley, Arvin Soepriatna

Keywords(s):

Category(s): Research Tools, Stem Cells and Regenerative Medicine

Method for Making Small Diameter Living Tubes

Overview We have developed a funnel-guide device for the noncontact manipulation and positioning of multicellular microtissues, to build macrotissues layer by layer. One specific application is the fabrication of biological tubes. Market Opportunity A long-standing problem in 3D tissue engineering is how to fabricate large tissue constructs with...

Published: 12/21/2022 | Inventor(s): Jeffrey Morgan, Kali Manning, Blanche Ip

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine

Bespoke Collagen Microfiber Scaffolds for Tissue Engineering

Overview In tissue engineering, cells are generally grown on a scaffold that emulates the cellular environment in the body. Together, the scaffold and cells can be implanted in a patient or serve as a testing platform, for example, to evaluate pharmaceuticals and toxicants. We have developed an accessible, low-cost, and automated method of preparing...

Published: 10/17/2022 | Inventor(s): Kareen Coulombe, Nicholas Kaiser

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine

Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)

Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release Overview Effective “smart” fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure “smart” delivery system for...

Published: 7/14/2020 | Inventor(s): Edith Mathiowitz, Richard Hopkins, Danya Lavin (formerly Decoteau)

Keywords(s):

Category(s): Drug Delivery, Stem Cells and Regenerative Medicine, Therapeutics, Devices, Nanotechnology, Research Tools

Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)

Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...

Published: 4/28/2020 | Inventor(s): John Savage, Eric Rachlin, Andre Dehon, Charles Lieber

Keywords(s):

Category(s): Devices, Diagnostics, Engineering and Sensors, Environmental, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine

Biological Pick, Place, and Perfuse "BioP3" - Device to Engineer Thick Living Tissues with High Cell Density (Case 2220) (EA)

Engineering Thick Living Tissues with High Cell Density Overview The ability to build organs in vitro will have a far-reaching impact on the field of tissue engineering, as well as other areas of research that use animals. Cells cultured in 3D mimic native tissues and organs much more effectively than do those cultured in 2D. While significant advances...

Published: 4/7/2020 | Inventor(s): Jeffrey Morgan, Anubhav Tripathi, William Patterson Iii, John Murphy, Andrew Blakely

Keywords(s):

Category(s): Devices, Nanotechnology, Research Tools, Stem Cells and Regenerative Medicine

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