Search Results - stem+cells+and+regenerative+medicine

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Novel proangiogenic cocktails of growth factors and cytokines to revascularize ischemic tissue
Overview Revascularization of ischemic tissue can be achieved using growth factors to recapitulate native developmental and wound healing cascades, and stimulate angiogenesis and arteriogenesis. These pro-vasculogenic growth factor cocktails can also increase the efficacy and translatability of regenerative therapeutics for clinical uses. We have developed...
Published: 6/4/2023   |   Inventor(s): Kareen Coulombe, Alicia Minor
Keywords(s):  
Category(s): Stem Cells and Regenerative Medicine
Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmogenic Toxicity Responses
Overview To guide the development of atrial-specific drugs and evaluate their safety, there is a need for in vitro models to accurately assess the cardiotoxic effects of novel therapeutics in both atrial and ventricular cell populations, with high throughput. We have developed a robust in vitro 3D atrial tissue platform made from human-induced pluripotent...
Published: 6/4/2023   |   Inventor(s): Kareen Coulombe, Bum-Rak Choi, Tae Yun Kim, Mark Daley, Arvin Soepriatna
Keywords(s):  
Category(s): Research Tools, Stem Cells and Regenerative Medicine
Method for Making Small Diameter Living Tubes
Overview We have developed a funnel-guide device for the noncontact manipulation and positioning of multicellular microtissues, to build macrotissues layer by layer. One specific application is the fabrication of biological tubes. Market Opportunity A long-standing problem in 3D tissue engineering is how to fabricate large tissue constructs with...
Published: 12/21/2022   |   Inventor(s): Jeffrey Morgan, Kali Manning, Blanche Ip
Keywords(s):  
Category(s): Stem Cells and Regenerative Medicine
Bespoke Collagen Microfiber Scaffolds for Tissue Engineering
­Overview In tissue engineering, cells are generally grown on a scaffold that emulates the cellular environment in the body. Together, the scaffold and cells can be implanted in a patient or serve as a testing platform, for example, to evaluate pharmaceuticals and toxicants. We have developed an accessible, low-cost, and automated method of preparing...
Published: 10/17/2022   |   Inventor(s): Kareen Coulombe, Nicholas Kaiser
Keywords(s):  
Category(s): Stem Cells and Regenerative Medicine
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release Overview Effective “smart” fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure “smart” delivery system for...
Published: 7/14/2020   |   Inventor(s): Edith Mathiowitz, Richard Hopkins, Danya Lavin (formerly Decoteau)
Keywords(s):  
Category(s): Drug Delivery, Stem Cells and Regenerative Medicine, Therapeutics, Devices, Nanotechnology, Research Tools
Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)
Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...
Published: 4/28/2020   |   Inventor(s): John Savage, Eric Rachlin, Andre Dehon, Charles Lieber
Keywords(s):  
Category(s): Devices, Diagnostics, Engineering and Sensors, Environmental, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine
Biological Pick, Place, and Perfuse "BioP3" - Device to Engineer Thick Living Tissues with High Cell Density (Case 2220) (EA)
Engineering Thick Living Tissues with High Cell Density Overview The ability to build organs in vitro will have a far-reaching impact on the field of tissue engineering, as well as other areas of research that use animals. Cells cultured in 3D mimic native tissues and organs much more effectively than do those cultured in 2D. While significant advances...
Published: 4/7/2020   |   Inventor(s): Jeffrey Morgan, Anubhav Tripathi, William Patterson Iii, John Murphy, Andrew Blakely
Keywords(s):  
Category(s): Devices, Nanotechnology, Research Tools, Stem Cells and Regenerative Medicine
Advanced, Wireless, Implantable Neural Recording and Stimulation Microsystem (Case 2032)
Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With the advent of advanced materials, MEMs, microfluidics, nanotechnology and interdisciplinary research programs between engineering fields and the biomedical sciences, miniaturized, next generation devices are now being developed...
Published: 6/20/2012   |   Inventor(s): Arto Nurmikko, Ming Yin, William Patterson Iii, Juan Aceros, David Borton, Christopher Bull, Farah Laiwalla
Keywords(s):  
Category(s): Devices, Diagnostics, Drug Delivery, Engineering and Sensors, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Stem Cells and Regenerative Medicine
Interactive, Multilayer, Multivalued Volume-Rendering for Superior 3D Images from MRI or Other Data (Case 1492)
Principal Investigator:David Laidlaw, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RIBrief Description:Magnetic resonance imaging (MRI) is a well-established and powerful technique for elucidating structure and is used, for example, in medical applications to discriminate between normal and pathological tissue. The MRI image...
Published: 6/11/2012   |   Inventor(s): David Laidlaw, Andreas Wenger
Keywords(s):  
Category(s): Devices, Diagnostics, Engineering and Sensors, Instruments, Metabolic diseases, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine
Improved, Scalable, Optical Particle/Molecule Detector System by Solid State Energy Sources (Case 1494)
Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With environmental safety and defense/bioterrorism concerns, and the continuing drive for important medical breakthroughs, quick and accurate particle diagnostic capabilities have become increasingly important to identify and quantify...
Published: 6/11/2012   |   Inventor(s): Arto Nurmikko, Richard Chang
Keywords(s):  
Category(s): Devices, Diagnostics, Energy, Engineering and Sensors, Environmental, Instruments, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Stem Cells and Regenerative Medicine
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