Search Results - kareen+coulombe

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Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration

Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration Overview During a heart attack it is estimated that 1 billion cardiomyocytes (i.e. heart muscle cells) are killed. Unlike other organs in the body, the heart has a limited capacity to regenerate. This means that the cardiomyocytes lost during a heart attack are replaced...

Published: 11/25/2024 | Inventor(s): Kareen Coulombe, Kiera Dwyer, Rajeev Kant

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine

Mid-scale vessels in engineered tissue for regeneration

Overview Vascularization is a primary concern when developing implantable cardiac tissues, as it is critical for superior engraftment and integration. We have developed a method for engineering a vascular supply for engineered human myocardium to ensure tissue survival and engraftment upon implantation and improve therapeutic efficacy. Market Opportunity Myocardial...

Published: 8/22/2024 | Inventor(s): Kareen Coulombe, Rajeev Kant, Kiera Dwyer

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine

Novel proangiogenic cocktails of growth factors and cytokines to revascularize ischemic tissue

Overview Revascularization of ischemic tissue can be achieved using growth factors to recapitulate native developmental and wound healing cascades, and stimulate angiogenesis and arteriogenesis. These pro-vasculogenic growth factor cocktails can also increase the efficacy and translatability of regenerative therapeutics for clinical uses. We have developed...

Published: 6/4/2023 | Inventor(s): Kareen Coulombe, Alicia Minor

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine

Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmogenic Toxicity Responses

Overview To guide the development of atrial-specific drugs and evaluate their safety, there is a need for in vitro models to accurately assess the cardiotoxic effects of novel therapeutics in both atrial and ventricular cell populations, with high throughput. We have developed a robust in vitro 3D atrial tissue platform made from human-induced pluripotent...

Published: 6/4/2023 | Inventor(s): Kareen Coulombe, Bum-Rak Choi, Tae Yun Kim, Mark Daley, Arvin Soepriatna

Keywords(s):

Category(s): Research Tools, Stem Cells and Regenerative Medicine

Bespoke Collagen Microfiber Scaffolds for Tissue Engineering

Overview In tissue engineering, cells are generally grown on a scaffold that emulates the cellular environment in the body. Together, the scaffold and cells can be implanted in a patient or serve as a testing platform, for example, to evaluate pharmaceuticals and toxicants. We have developed an accessible, low-cost, and automated method of preparing...

Published: 10/17/2022 | Inventor(s): Kareen Coulombe, Nicholas Kaiser

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine