Search Results - research+tools

32 Results Sort By:
Compositions and Methods for Selectively Detecting and Purifying Line-1 cDNA Synthesized in Vivo
Overview Many age-related diseases, as well as aging itself, are closely associated with chronic low-level inflammation. We have invented a method for treating, preventing, and/or reversing age-associated inflammation by administering a reverse transcriptase inhibitor (RTI) to patients who have a level of retrotransposable element (RTE)-derived Line-1...
Published: 6/7/2023   |   Inventor(s): John Sedivy, Alexandra D'Ordine, Anna Petrashen
Category(s): Research Tools
Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmogenic Toxicity Responses
Overview To guide the development of atrial-specific drugs and evaluate their safety, there is a need for in vitro models to accurately assess the cardiotoxic effects of novel therapeutics in both atrial and ventricular cell populations, with high throughput. We have developed a robust in vitro 3D atrial tissue platform made from human-induced pluripotent...
Published: 6/4/2023   |   Inventor(s): Kareen Coulombe, Bum-Rak Choi, Tae Yun Kim, Mark Daley, Arvin Soepriatna
Category(s): Research Tools, Stem Cells and Regenerative Medicine
Automated Behavioral Analysis System
­Overview The manual annotation of video data in the life sciences creates a number of problems, including those resulting from inherent biases. We have developed a neural network system to identify and automate the labeling of behavior in videos of animal test subjects. Market Opportunity Many areas of the life sciences demand the manual annotation...
Published: 12/21/2022   |   Inventor(s): Thomas Serre, Youssef Barhomi, Kevin Bath, Sven Eberhardt, Zachary Nado
Category(s): Object Tracking, Research Tools
Hyper-compliant polymer particles
Overview Polymer microbeads have been used extensively for biomedical applications, including device calibration, drug delivery, tissue engineering, and encapsulation of therapeutic agents. But their effectiveness is limited by the lack of microbeads that are similar to living cells. Our novel method is the first to produce polymer microbeads with...
Published: 11/1/2022   |   Inventor(s): Eric Darling, Edith Mathiowitz, Nicholas Labriola
Category(s): Drug Delivery, Research Tools
SOCKS (Statistical Outlier Curation Kernel Software): A Modern, Efficient Tool for Outlier Detection and Curation
Overview Real-world signal acquisition through sensors is at the heart of the modern digital world, yet almost every signal acquisition system is contaminated with noise and outliers. Our data “sanitizer” tool provides a way to obtain uncorrupted observations. Market Opportunity It is increasingly evident that clarity of digital information...
Published: 11/1/2022   |   Inventor(s): Prasanta Pal, Judson Brewer
Category(s): Research Tools, Software
Novel Electrical Device to Dissociate Tissue Sections into Single Cells for Downstream Single-Cell Analysis
Overview Single-cell analysis is an important analytical tool for studying heterogeneous cellular populations, such as cancer tissues, where rare mutations can drive metastasis and treatment response outcome. A major limitation of the clinical translation of single-cell analysis is the difficulty of isolating single cells from complex tissues. Our...
Published: 10/17/2022   |   Inventor(s): Anubhav Tripathi, E. Celeste (Cel) Welch
Category(s): Instruments, Research Tools
Placental lipid bilayer for cell-free molecular interaction studies
­Overview Researchers and clinicians have a need for in vitro or in vivo tools to quantify placental interactions at the molecular scale. Lipid bilayers have been used to model biological interfaces, including those in the liver, red blood cells or myelin. We have developed a lipid bilayer that mimics the lipid composition of the placenta. Market...
Published: 10/17/2022   |   Inventor(s): Anita Shukla, Christina Bailey-Hytholt, Anubhav Tripathi
Category(s): Drug Delivery, Research Tools
System and Method for Measuring Distribution of Deformation Using Atomic Force (not leading)
Interferometric absolute and real-time surface curvature sensor insensitive to tilt, translation and vibration Overview Kyung-Suk Kim has developed a device to improve modern microscopes by allowing them to measure deformations in a surface at the resolution of mere atoms. The invention can improve the resolution of an atomic micrograph system...
Published: 8/3/2022   |   Inventor(s): Kyung-Suk Kim
Category(s): Research Tools
Combinatorial use of markers to isolate synaptic glia to generate synapses in a dish for high-throughput and high-content drug discovery and testing
­Platform for in vitro Analysis of Synaptic Glia and Neuromuscular Synapses Overview Novel in vitro technology to isolate and analyze the glial cells that form neuromuscular synapses will make it easier to discover and test drugs for conditions that affect peripheral nerves and skeletal muscles, such as amyotrophic lateral sclerosis (ALS), spinal...
Published: 2/28/2022   |   Inventor(s): Gregorio Valdez
Category(s): Central Nervous System(CNS), Research Tools
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases (Case 1939)
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases Overview Stroke and other neurological insults entail a build-up of waste materials in brain cells. One of the most common waste materials is glutamate, which is present in more than 50 percent of nervous tissue. Glutamate receptors are critical to neuronal functioning. Failure...
Published: 8/11/2021   |   Inventor(s): John Marshall, Mark Spaller, Dennis Goebel
Category(s): Neuroscience, Research Tools, Therapeutics
1 2 3 4 
© 2024. All Rights Reserved. Powered by Inteum