Search Results - research+tools

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System and Method for Measuring Distribution of Deformation Using Atomic Force (not leading)
Interferometric absolute and real-time surface curvature sensor insensitive to tilt, translation and vibration Overview Kyung-Suk Kim has developed a device to improve modern microscopes by allowing them to measure deformations in a surface at the resolution of mere atoms. The invention can improve the resolution of an atomic micrograph system...
Published: 8/3/2022   |   Inventor(s): Kyung-Suk Kim
Category(s): Research Tools
Combinatorial use of markers to isolate synaptic glia to generate synapses in a dish for high-throughput and high-content drug discovery and testing
­Platform for in vitro Analysis of Synaptic Glia and Neuromuscular Synapses Overview Novel in vitro technology to isolate and analyze the glial cells that form neuromuscular synapses will make it easier to discover and test drugs for conditions that affect peripheral nerves and skeletal muscles, such as amyotrophic lateral sclerosis (ALS), spinal...
Published: 2/28/2022   |   Inventor(s): Gregorio Valdez
Category(s): Central Nervous System(CNS), Research Tools
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases (Case 1939)
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases Overview Stroke and other neurological insults entail a build-up of waste materials in brain cells. One of the most common waste materials is glutamate, which is present in more than 50 percent of nervous tissue. Glutamate receptors are critical to neuronal functioning. Failure...
Published: 8/11/2021   |   Inventor(s): John Marshall, Mark Spaller, Dennis Goebel
Category(s): Neuroscience, Research Tools, Therapeutics
Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acids into Cells (Case 2055)
Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acid into Cells Overview The use of small interfering RNA (siRNA), which silences gene expression, holds great clinical promise for the treatment of a variety of diseases. Researchers have been exploring the clinical potential of siRNAs for over two decades, and the first siRNA-based therapeutic,...
Published: 7/27/2021   |   Inventor(s): Thomas Webster, Qian Chen, Yupeng Chen, Yingjie Guan
Category(s): Drug Delivery, Nanotechnology, Research Tools, Therapeutics, Diagnostics
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release Overview Effective “smart” fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure “smart” delivery system for...
Published: 7/14/2020   |   Inventor(s): Edith Mathiowitz, Richard Hopkins, Danya Lavin (formerly Decoteau)
Category(s): Drug Delivery, Stem Cells and Regenerative Medicine, Therapeutics, Devices, Nanotechnology, Research Tools
Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)
Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...
Published: 4/28/2020   |   Inventor(s): John Savage, Eric Rachlin, Andre Dehon, Charles Lieber
Category(s): Devices, Diagnostics, Engineering and Sensors, Environmental, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine
Automated Microfluidic Cryo-TEM Sample Prep for Optimal Visualization (Case 1966)
Automated Microfluidic Blotless Specimen Preparation for Cryo-TEM Overview Transmission electron microscopy (TEM) is an important imaging tool in many physical and biological scientific fields. Because current methods for preparing the thin TEM specimens are specific to the material being analyzed and the information being sought, many different...
Published: 4/28/2020   |   Inventor(s): Anubhav Tripathi, Jinkee Lee, Arijit Bose
Category(s): Devices, Engineering and Sensors, Instruments, Nanotechnology, Research Tools
Optimized, Cost Effective X-Ray Imaging that Rivals MRI: X-Ray Spatial Frequency Heterodyne Imaging with Protein-Based “Nanobubble” Contrast Agents
Principal Investigator: Christoph Rose-Petruck, PhD, ProfessorDepartment of ChemistryBrown UniversityProvidence, RIBrief Description:Spatial Frequency Heterodyne Imaging (SFHI) is a novel x-ray scatter imaging technique that utilizes nanoparticle contrast agents. Previous studies on SFHI have utilized only metal nanoparticle contrast agents such as...
Published: 4/8/2020   |   Inventor(s): Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
Category(s): Diagnostics, Drug Delivery, Instruments, Nanotechnology, Oncology, Research Tools
Biological Pick, Place, and Perfuse "BioP3" - Device to Engineer Thick Living Tissues with High Cell Density (Case 2220) (EA)
Engineering Thick Living Tissues with High Cell Density Overview The ability to build organs in vitro will have a far-reaching impact on the field of tissue engineering, as well as other areas of research that use animals. Cells cultured in 3D mimic native tissues and organs much more effectively than do those cultured in 2D. While significant advances...
Published: 4/7/2020   |   Inventor(s): Jeffrey Morgan, Anubhav Tripathi, William Patterson Iii, John Murphy, Andrew Blakely
Category(s): Devices, Nanotechnology, Research Tools, Stem Cells and Regenerative Medicine
Supergratings - Improved Detection and Processing of Optical Signals (Case 1466)
Principal Investigator:Jingming Xu, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:Gratings are optical devices used to achieve wavelength-dependent characteristics by means of optical interference effects. These wavelength-dependent optical characteristics can serve to reflect light of a specific wavelength while...
Published: 2/6/2015   |   Inventor(s): Daniel Levner, Martin Fay, Jingming Xu
Category(s): Devices, Engineering and Sensors, Instruments, Research Tools
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