Search Results - drug+discovery+platform

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Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model

Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model Overview The extracellular matrix (ECM) of the body is the network of proteins and other molecules that surrounds cells and tissues. The ECM is directly involved in a variety of essential cellular processes including structural support,...

Published: 11/25/2024 | Inventor(s): Jeffrey Morgan, Benjamin Wilks

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine, Research Tools, Drug Discovery Platform

Proprietary targeting of Oligonucleotide to vulnerable splicing events to efficiently silence genes

Overview The principle of antisense technology is the sequence-specific binding of an antisense oligonucleotide (ASO) to target mRNA and prevent gene translation. We have found the individual events that are most vulnerable to disruption in cancer cells and developed a method to target these events. We can further restrict the points of vulnerability...

Published: 10/12/2022 | Inventor(s): William Fairbrother, Jeremiah Buerer, David Glidden

Keywords(s):

Category(s): Drug Discovery Platform, Therapy Targets

Development and Use of a High-Throughput Screen to Identify Novel Modulators of the Corticotropin Releasing Factor Binding Protein

Development of a HT Screen to Identify Novel Modulators of the CRFBP Overview A connection between the corticotropin signaling pathway and alcohol use disorder (AUD) has been shown previously. We developed a high throughput screen to identify small molecule modulators of this pathway as potential therapeutics for AUD. Market Opportunity Currently...

Published: 2/22/2022 | Inventor(s): Carolina Haass-Koffler

Keywords(s):

Category(s): Drug Discovery Platform, Central Nervous System(CNS)