Search Results - jeffrey+morgan

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Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model

Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model Overview The extracellular matrix (ECM) of the body is the network of proteins and other molecules that surrounds cells and tissues. The ECM is directly involved in a variety of essential cellular processes including structural support,...

Published: 11/25/2024 | Inventor(s): Jeffrey Morgan, Benjamin Wilks

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine, Research Tools, Drug Discovery Platform

Two Compartment Model for Detecting the Toxicity of Liver Metabolites

Overview Liver toxicity is a significant reason many new drugs fail in clinical trials. Primary human hepatocytes (PHHs) are the current gold standard for in vitro liver models; however, they have a number of limitations. We have invented an easy-to-use two-compartment device that provides in vitro 3D high-throughput prediction for safety assessments...

Published: 5/20/2024 | Inventor(s): Kim Boekelheide, Jeffrey Morgan, Blanche Ip, Susan Hall, Hui Li

Keywords(s):

Category(s): Diagnostics

Method for Making Small Diameter Living Tubes

Overview We have developed a funnel-guide device for the noncontact manipulation and positioning of multicellular microtissues, to build macrotissues layer by layer. One specific application is the fabrication of biological tubes. Market Opportunity A long-standing problem in 3D tissue engineering is how to fabricate large tissue constructs with...

Published: 12/21/2022 | Inventor(s): Jeffrey Morgan, Kali Manning, Blanche Ip

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Category(s): Stem Cells and Regenerative Medicine

Biological Pick, Place, and Perfuse "BioP3" - Device to Engineer Thick Living Tissues with High Cell Density (Case 2220) (EA)

Engineering Thick Living Tissues with High Cell Density Overview The ability to build organs in vitro will have a far-reaching impact on the field of tissue engineering, as well as other areas of research that use animals. Cells cultured in 3D mimic native tissues and organs much more effectively than do those cultured in 2D. While significant advances...

Published: 4/7/2020 | Inventor(s): Jeffrey Morgan, Anubhav Tripathi, William Patterson Iii, John Murphy, Andrew Blakely

Keywords(s):

Category(s): Devices, Nanotechnology, Research Tools, Stem Cells and Regenerative Medicine

Screening Method for Inhibitors of Multidrug-Resistance Transporters (Case 2079)

Novel Screening Method for Inhibitors of Multidrug-Resistant Transporters Overview Drug transport is of fundamental importance to the efficacy and toxicity of all drugs. From the route of administration to the site of action, a drug encounters numerous biological barriers, including efflux pumps that pump drugs out of cells. Our novel method uses...

Published: 8/16/2012 | Inventor(s): Jeffrey Morgan, Anubhav Tripathi, Toni-Marie Achilli (formerly Ferrucc, Stephanie Mccalla

Keywords(s):

Category(s): Drug Delivery, Oncology, Research Tools, Diagnostics, Metabolic diseases