<?xml version="1.0" encoding="utf-8"?><rss version="2.0"><channel><title>Latest technologies from Brown University</title><link>http://brown.technologypublisher.com</link><description>Be the first to know about the latest inventions and technologies available from Brown University</description><language>en-US</language><pubDate>Tue, 14 Apr 2026 01:22:33 GMT</pubDate><lastBuildDate>Thu, 23 Oct 2025 09:48:18 GMT</lastBuildDate><docs>http://blogs.law.harvard.edu/tech/rss</docs><webMaster>jennifer_l_vieira@brown.edu</webMaster><copyright>Copyright 2026, Brown University</copyright><item><title>Antisense oligonucleotides for rescuing splicing mutations in hotspot exons</title><caseId>3514</caseId><link>http://brown.technologypublisher.com/technology/58928</link><description><![CDATA[An antisense oligonucleotide to rescue multiple splicing mutations in hotspot exons

Overview

Research by William Fairbrother at Brown University centers around a therapeutic use of ASOs to enhance splicing for various mutations using a single ASO. This can allow for the expansion of treatment options for a broader range of patients with the same underlying genetic disorder without the need for multiple ASO development. Fairbrother&rsquo;s &ldquo;one-size-fits-many&rdquo; therapeutic solution could be more cost effective for treating rare diseases. 

&nbsp;

Technology 

The research demonstr...]]></description><pubDate>Thu, 23 Oct 2025 09:48:18 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/58928</guid></item><item><title>A novel method to achieve polymeric nanoparticles loaded with peptide therapeutics, which display high encapsulation efficiency, low burst release, and long acting sustained
release profiles</title><caseId>3253</caseId><link>http://brown.technologypublisher.com/technology/58193</link><description>A novel method to achieve polymeric nanoparticles loaded with peptide therapeutics, which display high encapsulation efficiency, low burst release, and long acting sustained release profiles.

Overview

A major challenge in the field of peptide and protein therapeutics is effective administration and subsequent delivery to the site of action. Due to their high molecular weight and susceptibility to degradation by both enzymes and extreme pH values, peptides and proteins usually display poor absorption across epithelial membranes and exhibit low oral bioavailability. For this reason, peptide th...</description><pubDate>Wed, 13 Aug 2025 12:14:49 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/58193</guid></item><item><title>A novel molecular target for the treatment of heart failure with preserved ejection
fraction</title><caseId>3476</caseId><link>http://brown.technologypublisher.com/technology/58192</link><description><![CDATA[Kr&uuml;ppel-like factor 4 regulates pressure-induced cardiac hypertrophy

Overview

Cardiac hypertrophy, a key risk factor for heart failure and sudden cardiac death, arises from hemodynamic and neurohormonal stress, often culminating in adverse remodeling. While much of the focus has been on activators of hypertrophic signaling, this technology identifies Kr&uuml;ppel-like factor 4 (KLF4) as a novel transcriptional repressor that modulates the cardiomyocyte stress response. KLF4 is induced in cardiomyocytes following hypertrophic stimuli and, when overexpressed, it suppresses the expression ...]]></description><pubDate>Wed, 13 Aug 2025 12:05:51 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/58192</guid></item><item><title>The Floor Projection Maze: A novel rodent model system for studying how complex visual information guides behavior and cognition.</title><caseId>3500</caseId><link>http://brown.technologypublisher.com/technology/58191</link><description><![CDATA[Floor Projection Maze: A Novel Rodent Model System for Studying Visual Cognition

Overview
The Floor Projection Maze stands as an innovative rodent research platform, specifically designed to advance our understanding of visual information processing, learning, memory, and attention. This device projects two-dimensional visual cues onto the maze floor from beneath, utilizing a semi-transparent surface illuminated by a digital projector. This particular setup is biologically optimal for rodents, naturally aligning with their downward gaze. The maze&#39;s adaptable structure facilitates the use ...]]></description><pubDate>Wed, 13 Aug 2025 11:48:10 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/58191</guid></item><item><title>Reduced Graphene Oxide Interlayered LLZO Laminated Solid-State Electrolyte for
Arresting Lithium Dendrite Growth</title><caseId>3360</caseId><link>http://brown.technologypublisher.com/technology/57497</link><description>Reduced Graphene Oxide Interlayered LLZO Laminated Solid-State Electrolyte for Arresting Lithium Dendrite Growth

Overview

Solid-state lithium metal batteries using inorganic solid electrolytes are considered a next-generation energy storage solution due to their potential for higher energy density and improved safety over conventional liquid electrolyte-based batteries. However, a major challenge with solid-state electrolytes is their inability to prevent lithium metal dendrite penetration, which can cause short-circuiting and battery failure at practical current densities. This technology i...</description><pubDate>Wed, 04 Jun 2025 12:54:07 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/57497</guid></item><item><title>Computational simulations trained neural network to characterize non-visible material flaws from ultrasound real-life measurements</title><caseId>3192</caseId><link>http://brown.technologypublisher.com/technology/57495</link><description>Computational simulations trained neural network to characterize non-visible material flaws from ultrasound real-life measurements

Overview

Non-destructive testing (NDT) has been used as an important tool to detect flaws/crack-like anomalies to assess structural integrity for a wide variety of applications. Current in-field ultrasonic defect detection in pipelines relies heavily on interpretation of a human operator thus is not robust and large uncertainties remain in the detection. This technology presents a machine learning-based system for non-destructive evaluation (NDE) of materials and...</description><pubDate>Wed, 04 Jun 2025 12:29:48 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/57495</guid></item><item><title>A novel approach to enhance efficiency, stability, and reliability of perovskite solar cells (PSCs) simultaneously</title><caseId>3112</caseId><link>http://brown.technologypublisher.com/technology/57494</link><description><![CDATA[Perovskite Solar Cells with Self Assembled Monolayers

Overview

This technology describes a novel approach to improving the mechanical reliability and performance of perovskite solar cells (PSCs) through the use of halide-terminated self-assembled monolayers (halide-SAMs) as molecular &quot;glue&quot; between different layers of the solar cell. The innovation focuses on using these SAMs, particularly iodine-terminated SAMs (I-SAMs), to strengthen the typically weak interfaces between the metal halide perovskite (MHP) layer and both the electron transport layer (ETL) and hole transport layer (...]]></description><pubDate>Wed, 04 Jun 2025 12:19:16 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/57494</guid></item><item><title>Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference</title><caseId>3377</caseId><link>http://brown.technologypublisher.com/technology/57444</link><description>Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference

Overview

Biophysically detailed neural models are powerful tools for bridging scales in neuroscience, linking cellular and circuit-level mechanisms to macro-scale signals like EEG/MEG. These models incorporate ion channels, synaptic dynamics, and network connectivity to simulate how cellular properties generate population-level activity patterns observed in humans. By replicating features such as oscillatory rhythms or event-related potentials, they provide mechanistic...</description><pubDate>Wed, 28 May 2025 05:23:07 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/57444</guid></item><item><title>A novel method for achieving high accuracy typing on a virtual keyboard using an intracortical Brain Computer Interface.</title><caseId>3371J</caseId><link>http://brown.technologypublisher.com/technology/57423</link><description><![CDATA[A novel method for achieving high accuracy typing on a virtual keyboard using an intracortical Brain Computer Interface

Overview

From texting on a device to pressing buttons on appliances, finger motions are utilized to communicate and interact with devices in almost all aspects of life. Individuals with severe motor impairment, however, often lack complete control of their hands and/or fingers, causing these &ldquo;simple&rdquo; tasks to be impossible. Commercial speech-to-text products and eye tracking devices can be used to facilitate communication in these populations. However, there are...]]></description><pubDate>Thu, 22 May 2025 10:24:14 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/57423</guid></item><item><title>Process and method for novel biomarker discovery using electromagnetic beta signal waveforms for prediction and diagnosis of neurological disorders and brain states</title><caseId>3336</caseId><link>http://brown.technologypublisher.com/technology/57422</link><description>Dissecting beta waveforms using convolutional dictionary learning across sensory perception, aging, and disease

OVERVIEW

This technology is a system and method for analyzing brain wave patterns, specifically beta waves (13-30 Hz), to identify biomarkers that can predict neurological conditions and brain states. The technology leverages advanced signal processing and machine learning techniques to detect and analyze specific features within beta waveforms captured through MEG/EEG recordings. The system focuses on examining time-domain characteristics of these waveforms across multiple scenari...</description><pubDate>Thu, 22 May 2025 10:22:06 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/57422</guid></item><item><title>Dopamine (DA) control of blood-brain barrier (BBB) permeability</title><caseId>3277</caseId><link>http://brown.technologypublisher.com/technology/57421</link><description><![CDATA[Transient blood-brain barrier opening via brain subsystem stimulation&nbsp;

Overview

One of the primary obstacles of delivering pharmacological agents to the brain is the blood-brain barrier (BBB). This technology describes methods for selectively opening the BBB by stimulating dopaminergic neurons in specific areas of the midbrain, particularly the ventral tegmental area (VTA) and substantia nigra pars compacta. The key innovation is that BBB permeability can be increased through non-invasive behavioral stimuli like rewards or reward anticipation and through direct stimulation methods like ...]]></description><pubDate>Thu, 22 May 2025 10:20:27 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/57421</guid></item><item><title>A novel multi-sensor hardware and software system to realistically capture 3D and 4D spatiotemporal audiovisual representations of objects, hands and hand–object
interactions</title><caseId>3311</caseId><link>http://brown.technologypublisher.com/technology/56878</link><description><![CDATA[A novel multi-sensor hardware and software system to realistically&nbsp;capture 3D and 4D spatiotemporal audiovisual representations of objects, hands and hand&ndash;object interactions

Overview

From animating a character in a movie to analyzing an athlete&rsquo;s performance, 4D motion capture is a technique that allows the detailed tracking and analysis of a subject&rsquo;s dynamic movement in three dimensions (X,Y,Z) over time. Such technologies have widespread applications in enhancing the realism of digital characters, improving biomechanical performance of athletes and refining virtual...]]></description><pubDate>Mon, 21 Apr 2025 07:37:18 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/56878</guid></item><item><title>First in class use of the estrogen receptor-b agonist in treating Angelman syndrome and
relevant autism spectrum disorders</title><caseId>3343</caseId><link>http://brown.technologypublisher.com/technology/56445</link><description><![CDATA[Overview

Angelman syndrome is a genetic disorder caused by UBE3A gene dysfunction, leading to cognitive impairment, motor coordination issues, and developmental delays. Research suggests that oligodendroglial dysfunction, which affects myelination in the brain, contributes to these conditions. Based on the research, this invention discloses a novel method for treating Angelman syndrome (AS) and autism spectrum disorders (ASD) using repurposed non-steroidal selective estrogen receptor beta (ER&beta;) agonists. The method includes ER&beta; agonists as a targeted treatment, leveraging their abil...]]></description><pubDate>Thu, 06 Mar 2025 07:14:24 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/56445</guid></item><item><title>Yohimbine Rescue in Unidentified Drug Overdose</title><caseId>3341</caseId><link>http://brown.technologypublisher.com/technology/56444</link><description><![CDATA[Overview

Xylazine is an emerging national threat with no xylazine antidotes in use for human drug overdoses.&nbsp;


	Drug overdose deaths in the United States have been steadily rising since 2019. 


Technology&nbsp;

Researchers at Brown University have developed the use of alpha 2 adrenergic antagonists such as yohimbine for use in the reversal of drug overdose contributed to by xylazine and xylazine congeners, alcohol, and benzodiazepines in humans.&nbsp;

The invention includes a product for emergency use of yohimbine in the field as well as a combination product with naloxone. 

Market ...]]></description><pubDate>Thu, 06 Mar 2025 06:56:01 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/56444</guid></item><item><title>Artificial intelligence (AI) and Machine learning (ML) based graphical user interface (GUI) system for early detection of depression symptoms using facial expression recognition and electroencephalogram</title><caseId>3317J</caseId><link>http://brown.technologypublisher.com/technology/56442</link><description><![CDATA[Background&nbsp;

Major depressive disorder (MDD) is a detrimental mental condition that inhibits everyday activities for individuals.&nbsp;


	A leading cause of disability among psychological disorders, yet it remains widely undiagnosed and untreated due to lack of sensitive and reliable diagnostic tools and methods. 


Technology&nbsp;

To overcome these societal limitations, we introduce a sophisticated system that integrates Artificial Intelligence (AI) and Machine Learning (ML) within a Graphical User Interface (GUI) to facilitate the early detection of depressive symptoms.&nbsp;


	The ...]]></description><pubDate>Thu, 06 Mar 2025 06:20:38 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/56442</guid></item><item><title>A novel approach to the treatment of EGFR mutant non-small cell lung cancer (NSCLC)</title><caseId>3270</caseId><link>http://brown.technologypublisher.com/technology/56441</link><description><![CDATA[Background

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for ~85% of all lung cancer cases.&nbsp;


	NSCLC is slow growing and often diagnosed at later stages when it has already spread, making treatment difficult.&nbsp;
	Resistance to therapy is a major challenge in effectively treating patients with NSCLC.&nbsp;
	10-30% of patients with NSCLC harbor mutations of the epidermal growth factor receptor (EGFR) gene, which contributes to the drug resistance of first-in line therapies.


Technology&nbsp;

Novel approach to treat EGFR-mutant NSCLC and the ens...]]></description><pubDate>Wed, 05 Mar 2025 16:45:13 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/56441</guid></item><item><title>System for Closed-Loop Deep Brain Stimulation Using Neural and Behavioral Biomarkers of Specific Motor Features</title><caseId>3260J</caseId><link>http://brown.technologypublisher.com/technology/55891</link><description><![CDATA[System for Closed-Loop Deep Brain Stimulation Using Neural and Behavioral Biomarkers of Specific Motor Features

Overview

Parkinson&rsquo;s Disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously.&nbsp; Understanding the neurophysiological correlates of these different motor states could enable optimal closed-loop neuromodulation. Existing approaches to closed-loop deep brain stimulation (DBS) rely on generic, nonspecific biomarkers to drive stimulation. However, Parkinson&rsquo;s Disease is characterized by different forms of motor dysfunction and these di...]]></description><pubDate>Fri, 20 Dec 2024 04:54:53 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/55891</guid></item><item><title>SUBCUTANEOUS MULTICHANNEL WIRELESS EEG FOR CHRONIC HOME USE</title><caseId>3257</caseId><link>http://brown.technologypublisher.com/technology/55890</link><description>Subcutaneous Multi-Channel Wireless EEG For Continuous Home Monitoring

Overview

It is increasingly recognized that for many patients, like those with epilepsy, it can be of paramount importance to record neural activity continuously, 24/7, over weeks and months. Yet, no clinically viable system exists. Currently, the principal diagnostic method for the large Epilepsy patient population (~3 Million in US) is based on short term stays in a hospital. Clinically informative assessment could vastly improve diagnosis and patient care if one could record brain activity continuously for weeks or mon...</description><pubDate>Fri, 20 Dec 2024 04:47:35 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/55890</guid></item><item><title>Dual stimuli-responsive silver loaded nanoparticles eliminate bacterial biofilms</title><caseId>3333</caseId><link>http://brown.technologypublisher.com/technology/55688</link><description>Dual stimuli-responsive silver loaded 

nanoparticles eliminate bacterial biofilms

Overview

Bacterial biofilms are complex, 3D bacterial communities that are embedded in a self-produced matrix of extracellular polymeric substances. Although biofilms are a common occurrence in human infections, they are extremely difficult to eradicate as their matrix acts as a barrier that prevents the infiltration of antibiotics and other antimicrobial agents. Because of this, biofilm infections are a significant challenge for physicians to treat, often become chronic, and can lead to the development of ant...</description><pubDate>Mon, 25 Nov 2024 15:18:05 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/55688</guid></item><item><title>Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration</title><caseId>3281</caseId><link>http://brown.technologypublisher.com/technology/55687</link><description>Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration

Overview

During a heart attack it is estimated that 1 billion cardiomyocytes (i.e. heart muscle cells) are killed. Unlike other organs in the body, the heart has a limited capacity to regenerate. This means that the cardiomyocytes lost during a heart attack are replaced by non-contractile scar tissue, resulting in decreased contractility and overall function of the heart. Heart regenerative strategies are aimed at introducing functional cardiomyocytes into the injured heart to re-muscularize, re-engineer its funct...</description><pubDate>Mon, 25 Nov 2024 15:16:02 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/55687</guid></item><item><title>Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model</title><caseId>3226</caseId><link>http://brown.technologypublisher.com/technology/55686</link><description>Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model

Overview

The extracellular matrix (ECM) of the body is the network of proteins and other molecules that surrounds cells and tissues. The ECM is directly involved in a variety of essential cellular processes including structural support, cellular communication, growth, tissue organization and environmental signaling. The importance of ECM in tissue homeostasis and regulation is becoming increasingly recognized, as the hallmark of several diseases such as fibrosis and cancer is the ...</description><pubDate>Mon, 25 Nov 2024 15:15:34 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/55686</guid></item><item><title>A novel test to diagnose Normal Pressure Hydrocephalus (NPH) and predict shunt surgery benefit</title><caseId>3044J</caseId><link>http://brown.technologypublisher.com/technology/55685</link><description>A Novel Test to Diagnose Normal Pressure Hydrocephalus (NPH) and Predict Shunt Surgery

Overview

Normal pressure hydrocephalus (NPH) is a progressive neurological disorder characterized by the accumulation of cerebrospinal fluid (CSF) in the brain. NPH has devasting impacts on patient quality of life, including progressive neurodegeneration, locomotor dysfunction, urinary incontinence and cognitive decline. Unlike other neurodegenerative diseases, NPH can be effectively treated through surgical intervention in which a shunt is placed in the brain to drain excess CSF. Because this surgery is a...</description><pubDate>Mon, 25 Nov 2024 15:14:56 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/55685</guid></item><item><title>Burr hole mounted frameless stereotactic device (EA)</title><caseId>2255</caseId><link>http://brown.technologypublisher.com/technology/55677</link><description>Burr Hole Mounted Frameless Stereotactic Device

Overview

The ability to visualize a surgical field and navigate to the appropriate region of interest is imperative during minimally invasive surgeries. Stereotactic image guidance is an intervention which utilizes 3D imaging technology to locate targets of interest, such as tumors and/or lesions, during surgeries where visualization can be restricted, such as in neurosurgeries. In practice, intraoperative CT/MRI scanning is performed with fiducial markers which allow surgeons to render a 3D image of the surgical field that can be correlated wi...</description><pubDate>Mon, 25 Nov 2024 09:51:13 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/55677</guid></item><item><title>Endovascular coil device for embolization of blood vessels</title><caseId>3118J</caseId><link>http://brown.technologypublisher.com/technology/55676</link><description>Endovascular coil device for embolization of blood vessels

Overview

Endovascular embolization is a minimally invasive procedure in which a blood vessel is closed to prevent its bleeding and rupture. In practice, X-ray imaging is used to navigate a catheter to the region of interest at which an embolization material (i.e. coils, particles or glue) is injected to effectively close off blood flow to the abnormal vessel. This technique is utilized in a variety of treatment therapies such as aneurysms, spinal cord vascular malformation, uterine fibroids and certain types of tumors. In these cases...</description><pubDate>Mon, 25 Nov 2024 08:52:21 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/55676</guid></item><item><title>LARGE-SCALE WIRELESS BIOSENSOR NETWORKS FOR BIOMEDICAL DIAGNOSTICS</title><caseId>3186</caseId><link>http://brown.technologypublisher.com/technology/54962</link><description>Overview

Electronic sensors are increasingly prevalent in the world around us. Scalability, however, is complicated by the fact that the signals at each sensor location can vary both in time and in magnitude, but often must be read at once by a single transceiver. Current brain-computer interface research, as an example, is hampered by inefficiencies and bandwidth constraints. Our solution uses the brain as inspiration, and provides an event-driven communication strategy that enables the efficient transmission, accurate retrieval and interpretation of sparse events across a network of thousan...</description><pubDate>Thu, 22 Aug 2024 10:06:39 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54962</guid></item><item><title>Mid-scale vessels in engineered tissue for regeneration</title><caseId>3256</caseId><link>http://brown.technologypublisher.com/technology/54961</link><description><![CDATA[Overview

Vascularization is a primary concern when developing implantable cardiac tissues, as it is critical for superior engraftment and integration.&nbsp; We have developed a method for engineering a vascular supply for engineered human myocardium to ensure tissue survival and engraftment upon implantation and improve therapeutic efficacy. 

Market Opportunity

Myocardial infarction (MI) interrupts vascular blood flow to downstream muscle, resulting in ischemia and necrosis of cardiac tissue. Restoration of cardiac contractility after MI is important to prevent heart failure. Research on he...]]></description><pubDate>Thu, 22 Aug 2024 09:55:17 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54961</guid></item><item><title>A novel, modular, apparatus to measure rodent spatial and social cognition without the limitations of currently used apparatuses</title><caseId>3185</caseId><link>http://brown.technologypublisher.com/technology/54851</link><description><![CDATA[Overview

The ability to understand, create and maintain social relationships is a fundamental part of life. Emerging research shows there is a critical link between the social networks we create and our spatial cognition. For example, social relationships are often described in terms of space, varying from &ldquo;close&rdquo; to &ldquo;distant.&rdquo; In exploring the mechanistic basis for this connection, it is vital to utilize animal models such as rats, which are both highly social and excellent spatial navigators. However, current apparatuses to house and perform testing on rodents are re...]]></description><pubDate>Tue, 06 Aug 2024 12:47:23 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54851</guid></item><item><title>Ultra-Sensitive Solid-State Magnetic Field Sensors based on Anomalous Hall Effect</title><caseId>3052</caseId><link>http://brown.technologypublisher.com/technology/54370</link><description>Overview

Magnetic sensors are widely used in industry, for example, in automotive applications, information storage, metrology, medical devices, and IoT sensors. Our novel high-performing magnetic sensors have both ultra-detectability and high stability, and are inexpensive to manufacture. They also have low intrinsic noise, high temperature stability, low power consumption, DC to high frequency response, and low cross-field error.

Market Opportunity

Nearly all objects and systems around us generate a magnetic field that can be used to gain information about them. But the relatively low sen...</description><pubDate>Fri, 07 Jun 2024 07:54:46 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54370</guid></item><item><title>Inhibition of the Egr2 promoter Antisense RNA with oligonucleotide GapmeRs as novel
RNA therapy for human neuropathies</title><caseId>3238J</caseId><link>http://brown.technologypublisher.com/technology/54357</link><description><![CDATA[Overview

Peripheral neuropathy can be caused by trauma, disease, or chemotherapy. We have developed sustained-release formulations that treat human neuropathies by prompting remyelination of the damaged nerves. The formulations are delivered by injection at the site of nerve damage, using a polymeric gel.

Market Opportunity

Peripheral nerve damage can interfere greatly with a patient&rsquo;s daily life; the body&rsquo;s natural healing process is usually insufficient to completely restore function. The nerves can be damaged by trauma; by diseases such as Charcot-Marie-Tooth disease, Guillai...]]></description><pubDate>Thu, 06 Jun 2024 08:15:34 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54357</guid></item><item><title>Time-Lapse Light Field Photography With a 7 DoF Arm</title><caseId>2472</caseId><link>http://brown.technologypublisher.com/technology/54356</link><description><![CDATA[Overview

Robots that have an arm for gripping and grasping may be asked to pick up objects with a wide variety of shapes, weights, sizes, and colors. One particularly challenging job for a robot is to grasp shiny or transparent objects, whose translucence or reflections may fool the robotic vision system.

Tellex and colleagues invented a robotic arm design in which the camera that acts as the machine&rsquo;s &ldquo;eye&rdquo; is embedded within the arm itself. In this way, the robot necessarily sees the shiny or transparent object from a variety of angles as its arm attempts to pick up the i...]]></description><pubDate>Thu, 06 Jun 2024 07:51:59 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54356</guid></item><item><title>Sequence-to-Sequence Language Grounding of Non-Markovian Task Specifications</title><caseId>2559</caseId><link>http://brown.technologypublisher.com/technology/54355</link><description><![CDATA[Overview

There are existing ways to translate a person&rsquo;s instructions for a robot into a series of logical functions that the machine can execute to achieve the goal, such as Linear Temporal Logic (LTL). Such approaches are powerful, but they are also technical and complex; a non-expert could not be expected to learn this language to communicate with a robot. 

Tellex and colleagues have invented a sequence-to-sequence mapping technique that allows a robot to learn how to translate between instructions said in plain English LTL expressions that the machine knows how to execute.

Market ...]]></description><pubDate>Thu, 06 Jun 2024 07:50:47 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54355</guid></item><item><title>Probabilistic Object Models for Robust, Repeatable Pick-and-Place</title><caseId>2534</caseId><link>http://brown.technologypublisher.com/technology/54354</link><description><![CDATA[Overview

Picking up an object is one of the simplest tasks a person can perform. For a robot, however, such a task requires a suite of surprisingly complex abilities. The machine must have a capable grasping hand capable of exerting just the right amount of force&mdash;enough to avoid dropping the object, but not so much as to crush it. The robot must also have sophisticated vision and object recognition, especially if it is to navigate an open environment to find and grasp a particular object, such as a household robot may be asked to do.

Tellex&rsquo;s method teaches a manipulator robot to...]]></description><pubDate>Thu, 06 Jun 2024 07:42:18 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54354</guid></item><item><title>Multi-Object Search Using Object-Oriented POMDPs</title><caseId>2582</caseId><link>http://brown.technologypublisher.com/technology/54353</link><description><![CDATA[Overview

&nbsp;

The robots of the future may be called upon to search for a variety of objects and to do so in unfamiliar territory. An established method called Partially Observable Markov Decision Processes (POMDPs) allows a robot to make decisions in the correct order even faced with uncertain conditions. 

However, these POMDPs struggle to keep pace as the number of places the machine must search or the number of items it is looking for increases. Tellex&rsquo;s team has invented a new version of this idea called Multi-Object Search OO-POMDP (MOS OO-POMDP) that can more easily scale to l...]]></description><pubDate>Thu, 06 Jun 2024 07:38:21 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54353</guid></item><item><title>Accurately and Efficiently Interpreting Human-Robot Instructions of Varying Granularities</title><caseId>2509</caseId><link>http://brown.technologypublisher.com/technology/54352</link><description><![CDATA[Overview

Robots that work alongside humans must be able to understand directions and instructions in natural language. But not all instructions are created equal. For example, a human operating a forklift intuitively understands the difference between what researchers would call a high-level action, like &ldquo;grab a pallet,&rdquo; and a low-level action, like &ldquo;tilt back a little bit.&rdquo; 

While robots already can connect commands given in natural language to the tasks they need to fulfill, they generally assume a single, fixed level of abstraction in these tasks. Tellex&rsquo;s in...]]></description><pubDate>Thu, 06 Jun 2024 07:36:06 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54352</guid></item><item><title>A Power Mapping and Modeling System for Integrated Circuits</title><caseId>2213</caseId><link>http://brown.technologypublisher.com/technology/54351</link><description><![CDATA[Overview

One of the biggest challenges for computer chip architects is figuring out the power supply and power distribution, because this limits the performance and reliability of semiconductor-based chips. However, the complex nature of modern multi-core processors, in addition to the way that power usage varies dep-ending on workload, makes it exceedingly difficult to model and measure power within the system.

Sherief Reda&rsquo;s invention offers a method for modeling the power inside an integrated circuit by using the effects that all that energy creates. Reda measures the thermal infrar...]]></description><pubDate>Thu, 06 Jun 2024 07:32:48 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54351</guid></item><item><title>Two Compartment Model for Detecting the Toxicity of Liver Metabolites</title><caseId>2578</caseId><link>http://brown.technologypublisher.com/technology/54219</link><description>Overview

Liver toxicity is a significant reason many new drugs fail in clinical trials. Primary human hepatocytes (PHHs) are the current gold standard for in vitro liver models; however, they have a number of limitations. We have invented an easy-to-use two-compartment device that provides in vitro 3D high-throughput prediction for safety assessments through the liver-metabolizing capability of its microtissue plates.

Market Opportunity

The liver is the major organ that contributes to the metabolism of biomolecules, including drugs and chemicals. Often, new drugs and chemicals are not toxic...</description><pubDate>Mon, 20 May 2024 08:41:00 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/54219</guid></item><item><title>Combining recombinant protein and fibrin spray to increase wound healing</title><caseId>2603</caseId><link>http://brown.technologypublisher.com/technology/53400</link><description>Overview

A little-appreciated complication of pneumonia in surgical patients is decreased wound healing. We have invented a treatment method that uses fibrin spray as a vehicle to topically deliver one or more chemokines to accelerate wound healing. Advantages of our method include effectiveness, ease of application, and the use of already-approved clinical products.

Market Opportunity

Most studies of immune system function focus on single insults, such as infection or injury. Though post-surgical pneumonia is a well-known clinical complication, very little is known about the interactions b...</description><pubDate>Thu, 22 Feb 2024 10:59:35 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/53400</guid></item><item><title>Parenteral and oral delivery of antibodies</title><caseId>2471J</caseId><link>http://brown.technologypublisher.com/technology/53398</link><description>Overview

With their high molecular weight and susceptibility to degradation by both enzymes and extreme pH values, proteins such as antibodies usually display poor absorption across epithelial membranes and low oral bioavailability. We have invented pharmaceutical compositions that contain micronized antibodies encapsulated and/or dispersed in polymeric particles for delivery. Formulated for oral, subcutaneous, percutaneous, or mucosal administration, they can be used to treat a variety of diseases, disorders, and/or conditions, including autoimmune disorders and gastrointestinal cancers.

Ma...</description><pubDate>Thu, 22 Feb 2024 10:15:42 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/53398</guid></item><item><title>A new approach to supply oxygen to reactor that greatly simplifies the compound
specific carbon isotopic analysis using mass spectrometer</title><caseId>3223</caseId><link>http://brown.technologypublisher.com/technology/53143</link><description><![CDATA[Extending the Life of a System Used for Compound-Specific Carbon Isotopic Analysis

Overview

We have developed a system that extends the life of the commercial gas chromatography (GC) and mass spectrometry systems used for compound-specific isotopic analysis (CSIA), by incorporating an automatic pressure control (APC) to maintain oxidative capacity over prolonged use.&nbsp;

Market Opportunity

CSIA is a common and powerful analytical technique used in areas such as earth and environmental science, and forensic science. It can be performed with commercial GC and/or mass spectrometry. The oxid...]]></description><pubDate>Wed, 24 Jan 2024 09:19:13 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/53143</guid></item><item><title>Alluaudite Nanoplates as Cathode Materials for Sodium Rechargeable Batteries</title><caseId>2342</caseId><link>http://brown.technologypublisher.com/technology/51771</link><description><![CDATA[Overview

Current lithium-ion (Li-ion) battery technology is limited in terms of energy capacity, charging speed, and manufacturing cost. We have invented new alluaudite compounds for use as cathode materials for sodium-ion (Na-ion) batteries, which will enable large-scale battery applications that are naturally abundant and sustainable.

&nbsp;Market Opportunity

The demand for batteries with more efficient energy storage systems is driving the development of batteries with higher energy density, increased depth of discharge, longer life cycles, and lighter, more flexible forms. Most current ...]]></description><pubDate>Tue, 25 Jul 2023 14:43:08 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51771</guid></item><item><title>Small-Molecule Inhibitors of the L-1 Endonuclease Domain</title><caseId>3287</caseId><link>http://brown.technologypublisher.com/technology/51770</link><description>Overview

Chronic inflammation is a hallmark of a number of age-related diseases, as well as of aging itself. Nuclear element-1 (L1) plays a key role in this inflammatory process. We have developed the first inhibitors of the L-1 endonuclease (EN) domain and the first of any retrotransposon-encoded EN. Our technology sheds light on the regulators that control age-related inflammation, on the causal relationship of these regulators to chronic degenerative diseases, and on potential methods for preventing and reducing age-associated inflammation. 

Market Opportunity

One hallmark of aging is th...</description><pubDate>Tue, 25 Jul 2023 14:18:34 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51770</guid></item><item><title>Anti-Cancer Maleimide Derivatives for Use with Immune Checkpoint Blockade</title><caseId>3198</caseId><link>http://brown.technologypublisher.com/technology/51311</link><description>Overview

We have invented a cancer treatment that consists of administering an anti-cancer maleimide derivative together with an immune checkpoint blockade.

Market Opportunity

Globally, colorectal cancer (CRC) ranks third in incidence and second in mortality. The U.S. Food and Drug Administration recently approved the checkpoint inhibitors nivolumab and pembrolizumab for microsatellite instability-high (MSI-H) CRC cases after chemotherapy. Although immune checkpoint blockade (ICB) clinical trials have demonstrated their efficiency in cases of MSI-H CRC, a notable lack of response has been o...</description><pubDate>Wed, 07 Jun 2023 09:54:48 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51311</guid></item><item><title>Use of CRTH2 Antagonist to Treat Neuromyelitis Optica and Other Autoimmune Disorders of the Central Nervous System</title><caseId>3302J</caseId><link>http://brown.technologypublisher.com/technology/51310</link><description>Overview

The detrimental effects of neuroinflammation, especially neuromyelitis optica spectrum disorder (NMOSD), on cognitive performance can include severe vision loss, motor deficits, and cognitive decline. We have invented a method that targets the detrimental effects of neuroinflammation on cognitive performance by using a CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) antagonist as an CHI3L1 inhibitor.

Market Opportunity

The neurological disorder NMOSD is characterized by inflammation of the optic nerves and spinal cord. One type of NMOSD, the result of pr...</description><pubDate>Wed, 07 Jun 2023 09:47:09 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51310</guid></item><item><title>Compositions and Methods for Selectively Detecting and Purifying Line-1 cDNA Synthesized in Vivo</title><caseId>3217</caseId><link>http://brown.technologypublisher.com/technology/51308</link><description><![CDATA[Overview

Many age-related diseases, as well as aging itself, are closely associated with chronic low-level inflammation. We have invented a method for treating, preventing, and/or reversing age-associated inflammation by administering a reverse transcriptase inhibitor (RTI) to patients who have a level of retrotransposable element (RTE)-derived Line-1 complementary DNA (cDNA) that is higher than a reference.

Market Opportunity

Many age-related chronic conditions such as heart disease, cancer, diabetes, Alzheimer&#39;s disease, and infection, as well as aging itself, are closely associated w...]]></description><pubDate>Wed, 07 Jun 2023 09:38:24 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51308</guid></item><item><title>Covid Prevention and Treatment Using an Integrin Inhibitor</title><caseId>3209J</caseId><link>http://brown.technologypublisher.com/technology/51307</link><description>Overview

Although several highly effective vaccines against COVID-19 have been developed, the disease remains a threat to public health. We have invented a method of preventing or treating COVID-19 through administration of an integrin inhibitor such as GLPG-0187.

Market Opportunity

Although several highly effective vaccines against COVID-19 have been developed, the disease remains a threat to public health because of breakthrough cases, the current improbability of achieving herd immunity, reluctance to vaccinate among significant segments of the population, lack of available vaccines in m...</description><pubDate>Wed, 07 Jun 2023 09:32:10 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51307</guid></item><item><title>Treating Glioblastoma, Metastatic Melanoma, and Other Tumors Involving CNS Metastases</title><caseId>3212</caseId><link>http://brown.technologypublisher.com/technology/51305</link><description><![CDATA[Overview

Metastasis involving the spread of systemic cancer to the brain typically results in neurologic disability and death; current treatments are largely palliative in nature. We have invented a method of treatment based on determining whether the patient has an increased level of MDM2/MDM4 genes and/or proteins and/or a decreased level of CDKN2A genes and/or proteins.

Market Opportunity

Brain metastases are the most common malignancy encountered in the central nervous system (CNS), with up to 30&minus;40 percent of cancer patients developing brain metastases at some point during the co...]]></description><pubDate>Wed, 07 Jun 2023 09:18:20 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51305</guid></item><item><title>Composition for Increased Systemic Uptake of Nanoparticles Following Oral or Mucosal Drug Delivery</title><caseId>3164</caseId><link>http://brown.technologypublisher.com/technology/51304</link><description>Overview

The use of oral drug delivery systems based on polymeric particles has been historically limited by stomach acidity, enzymatic activity, and low penetration through the GI tissue. We have invented pharmaceutical formulations containing coated particles that have increased systemic uptake into the blood and/or increased local GI uptake. The coated particles are absorbed by a mucous membrane, such as intestinal mucosa and/or GI tissue.

Market Opportunity

Though oral delivery systems based on polymeric particles are the preferred route for drug administration, their use has been limit...</description><pubDate>Wed, 07 Jun 2023 08:47:29 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51304</guid></item><item><title>Novel proangiogenic cocktails of growth factors and cytokines to revascularize ischemic tissue</title><caseId>3170</caseId><link>http://brown.technologypublisher.com/technology/51280</link><description>Overview

Revascularization of ischemic tissue can be achieved using growth factors to recapitulate native developmental and wound healing cascades, and stimulate angiogenesis and arteriogenesis. These pro-vasculogenic growth factor cocktails can also increase the efficacy and translatability of regenerative therapeutics for clinical uses. We have developed an ultra-thin, surgically implanted hydrogel film for local delivery of biologics and pro-vascularization factors. We have also developed pro-vasculogenic cocktails that increase the efficacy and translatability of regenerative therapeutics...</description><pubDate>Sun, 04 Jun 2023 15:08:48 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51280</guid></item><item><title>Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmogenic Toxicity Responses</title><caseId>3128J</caseId><link>http://brown.technologypublisher.com/technology/51279</link><description>Overview

To guide the development of atrial-specific drugs and evaluate their safety, there is a need for in vitro models to accurately assess the cardiotoxic effects of novel therapeutics in both atrial and ventricular cell populations, with high throughput. We have developed a robust in vitro 3D atrial tissue platform made from human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes that enables chamber-specific evaluation of arrhythmic risk. 

Market Opportunity

Although atrial fibrillation is the most prevalent electrical conduction disorder, the mechanisms underlying atrial a...</description><pubDate>Sun, 04 Jun 2023 15:01:48 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51279</guid></item><item><title>A Novel Liposomal Formulation to Target Candida</title><caseId>2599</caseId><link>http://brown.technologypublisher.com/technology/51278</link><description>Overview

The yeast Candida lives on the skin and in many places inside the human body, often without causing any health problems. However, it can cause infections, especially if it reaches the bloodstream.

Shukla and colleagues have developed a liposomal formulation containing a novel targeting peptide for delivering antifungal treatments inside the body to the exact site of infection. This technique is effective at reducing fungal load, and the ability to target the site of infection can minimize damage to healthy human cells and reduce the development of antifungal resistance.

Market Oppo...</description><pubDate>Sun, 04 Jun 2023 14:55:51 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51278</guid></item><item><title>A Scalable Method for Preparing Cu Catalysts for Electrochemical CO2 Reduction to C2+ Products: Anodic Halogenation and Subsequent Surface Reconstruction</title><caseId>3016</caseId><link>http://brown.technologypublisher.com/technology/51168</link><description><![CDATA[Overview

One crucial way to mitigate the rising levels of carbon dioxide (CO2) in the atmosphere and the harmful climate change effects caused by this increase is to capture CO2 and, if possible, convert the carbon therein to a useable product. However, there is currently no known process or technology to create, at scale, the electrocatalysts needed to power a reduction reaction for a large amount of CO2 to new products where carbon atoms are bonded together. 

Palmore and colleagues&rsquo; invention demonstrates a way to fill that technological gap. They have developed a method for preparin...]]></description><pubDate>Wed, 24 May 2023 11:59:57 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51168</guid></item><item><title>Nanoparticles as Catalyst for Formation of Rigid Organic Polymers with Controlled Polymerization</title><caseId>2612</caseId><link>http://brown.technologypublisher.com/technology/51167</link><description>Overview

Polybenzoxazole (PBO) fibers have usually been made by condensing diaminobenzene diol and terephthalic acid with polyphosphoric acid (PA), which serves as both solvent and catalyst. The use of PA, however, causes the PBO fibers to be contaminated with PA units. We have invented a nanoparticle (NP)-based catalytic method to synthesize functional polymers with controlled polymerization, purity, and properties. Our method addresses the problem of PBO purity, helping the PBO to maintain its thermomechanical stability.

Market Opportunity

PBO fibers are used for producing body armor, fla...</description><pubDate>Wed, 24 May 2023 11:57:00 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51167</guid></item><item><title>Overpotential and Selectivity in the Electrochemical Conversion of CO2 into Fuels</title><caseId>2313</caseId><link>http://brown.technologypublisher.com/technology/51166</link><description>Overview

According to the Environmental Protection Agency, carbon dioxide (CO2) accounts for 80% of all greenhouse gas emissions. While much attention is focused on cutting CO2 by transitioning to clean energy sources, another important way to reduce the amount of carbon entering the atmosphere is to convert CO2 and carbon monoxide into useful products. 

Peterson and colleagues are tackling one of the biggest barriers to the capture and reuse of carbon; devising cost-effective catalysts to drive the electrochemical reactions. Better catalysts would make it easier and less energy-intensive to...</description><pubDate>Wed, 24 May 2023 10:06:10 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51166</guid></item><item><title>Solar-Enriched Biofuels via Looped Oxide Catalysis</title><caseId>2206</caseId><link>http://brown.technologypublisher.com/technology/51165</link><description>Overview

The development of efficient hydroprocessing technologies to upgrade bio-oils would go far toward meeting the need for a clean and renewable source of transportation fuel. We have invented an integrated thermochemical process, also known as a looped-oxide catalysis, which produces an upgraded biofuel from biomass-derived feedstock.

Market Opportunity

Instabilities in the price of petroleum and the environmental impact of fossil fuel combustion are key factors in the need for a clean and renewable source of transportation fuel, particularly one that does not require major changes to...</description><pubDate>Wed, 24 May 2023 09:54:08 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51165</guid></item><item><title>A process (and/or catalyst) to make ultra-high molecular weight polylactide</title><caseId>3189</caseId><link>http://brown.technologypublisher.com/technology/51139</link><description><![CDATA[Overview

Polylactic acid (PLA) is one of the most promising kinds of bioplastics. It is a bio-sourced, degradable polymer that can be made using renewable materials and represents a crucial way to reduce our dependence on single-use plastics sourced from fossil fuels. However, there has not been an efficient way to create the ultra-high molecular weight (UHMW) PLA that would allow the material to be used at an industrial scale.

Dr. Robinson&rsquo;s team has developed a process and catalyst for creating ultra-high molecular weight polylactide at room temperature. The low-toxicity catalyst can...]]></description><pubDate>Sun, 21 May 2023 12:40:02 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51139</guid></item><item><title>A novel method to fabricate nanostructured bulk materials with tailored grain-boundary conditions</title><caseId>3042</caseId><link>http://brown.technologypublisher.com/technology/51138</link><description><![CDATA[Overview

Engineering at the grain boundary - the meeting points of where the crystals or grains of varying size and orientation that comprise a material meet&mdash;is crucial to fully utilizing a new material. This area of research is pivotal to fully utilizing the mechanical, electrical, and thermal transport properties of a variety of materials. However, precision grain-boundary engineering is difficult to achieve with current top-down methods. 

Ou Chen has invented a process for creating bulk grain-boundary materials from colloidal metal nanocrystals, using surface ligand engineering foll...]]></description><pubDate>Sun, 21 May 2023 12:32:46 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51138</guid></item><item><title>Context-Aware Self-Calibration for Autonomous Control of Assistive Devices</title><caseId>2299J</caseId><link>http://brown.technologypublisher.com/technology/51137</link><description>Overview

Existing assistive devices for people with severe motor disabilities rely heavily on residual motor function. Recent brain-computer interfaces (BCIs), which decode neural activity directly from the brain, provide disabled persons with limited ability to autonomously control assistive devices. We have invented a neural interface system that can form a bridge across the compromised neural pathway, restoring motor function of disabled persons to functional level.

Market Opportunity

Existing assistive devices for people with severe motor disabilities are inherently limited, as they rel...</description><pubDate>Sun, 21 May 2023 10:19:53 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/51137</guid></item><item><title>Aspartic Protease-Triggered Antifungal Hydrogels</title><caseId>2500</caseId><link>http://brown.technologypublisher.com/technology/50926</link><description>Overview

Antimicrobial-resistant Candida is a growing public health problem. We have developed an aspartic protease-triggered hydrogel system that selectively delivers an antifungal drug only in the presence of a virulent, pathogenic Candida fungal infection. 

Market Opportunity

Candida is the most common cause of fungal infections, and antimicrobial-resistant Candida is a growing threat that increases the severity of these infections. There are currently only four main classes of antifungal drugs. Certain virulent Candida albicans strains already show resistance to three of them, and a rec...</description><pubDate>Thu, 27 Apr 2023 19:24:18 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/50926</guid></item><item><title>Chitinase 3-like-1 (CHI3L1) as Biomarker for Hermansky-Pudlak Pulmonary Fibrosis</title><caseId>2283J</caseId><link>http://brown.technologypublisher.com/technology/50175</link><description>Overview

Hermansky-Pudlak syndrome (HPS) is a group of autosomal recessive disorders caused by mutations that affect the function of lysosome-related organelles (LROs). All HPS patients have oculocutaneous albinism with visual impairment, and many have blood platelet dysfunction with bleeding disorder. HPS-1 and HPS-4 patients, who have mutations of BLOC-3 (biogenesis of lysosome-related organelles complex 3), also develop pulmonary fibrosis, usually in the fourth or fifth decade of life. Because HPS fibrosis is progressive and untreatable, it is the leading cause of death in these patients. ...</description><pubDate>Sat, 21 Jan 2023 19:57:28 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/50175</guid></item><item><title>L1 Inhibitor to Prevent Age-Associated Inflammation and Disease</title><caseId>3029</caseId><link>http://brown.technologypublisher.com/technology/50174</link><description>Overview

One hallmark of aging is the accumulation of senescent cells that contribute to sterile inflammation, which underlies many age-associated diseases such as osteoarthritis, cancer, and neurodegeneration. Nuclear element-1 (L1), which represents approximately 17% of the human genome, plays a key role in this process. We are identifying candidates to develop into inhibitors specific to the L1 endonuclease (EN), as a potential way to prevent these age-related diseases.

Market Opportunity

Though nuclear element-1 (L1) repeats are normally repressed in heterochromatic (genetically inactiv...</description><pubDate>Sat, 21 Jan 2023 19:50:23 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/50174</guid></item><item><title>iBCI System to Control Multiple Devices</title><caseId>3181J</caseId><link>http://brown.technologypublisher.com/technology/50034</link><description><![CDATA[&shy;Overview

Until now, brain computer interface (BCI) systems have allowed people with paralysis to control only a single device, often under the guidance of a caretaker or secondary operator. Our novel BCI system enables users to control multiple devices, switching among them under their own volition.

Market Opportunity

Numerous intracortical BCI systems are in development that can decode neural signals and enable individuals with paralysis to control external devices, such as a desktop PC, tablet, or robotic arm. Adoption of BCI assistive technology by users in the home will require tha...]]></description><pubDate>Wed, 21 Dec 2022 15:35:33 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/50034</guid></item><item><title>Automated Behavioral Analysis System</title><caseId>2462</caseId><link>http://brown.technologypublisher.com/technology/50033</link><description><![CDATA[&shy;Overview

The manual annotation of video data in the life sciences creates a number of problems, including those resulting from inherent biases. We have developed a neural network system to identify and automate the labeling of behavior in videos of animal test subjects.

Market Opportunity

Many areas of the life sciences demand the manual annotation of large amounts of video data. Not only does this create major bottlenecks, but a number of controversies in behavioral studies have arisen because of the inherent biases and challenges associated with the manual annotation of behavior. Man...]]></description><pubDate>Wed, 21 Dec 2022 15:30:52 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/50033</guid></item><item><title>Method for Making Small Diameter Living Tubes</title><caseId>2452</caseId><link>http://brown.technologypublisher.com/technology/50032</link><description><![CDATA[Overview

We have developed a funnel-guide device for the noncontact manipulation and positioning of multicellular microtissues, to build macrotissues layer by layer. One specific application is the fabrication of biological tubes. 

Market Opportunity

A long-standing problem in 3D tissue engineering is how to fabricate large tissue constructs with high densities of living cells, similar to natural organs and tissues. There is a specific need for tubular components.&nbsp; 

Innovation and Meaningful Advantages

Our device uses a funnel guide comprising a free fall chamber, a funnel chamber, a...]]></description><pubDate>Wed, 21 Dec 2022 15:21:13 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/50032</guid></item><item><title>Integrated Platforms for Microscale Spatially Resolved Electrochemical Measurements</title><caseId>3022</caseId><link>http://brown.technologypublisher.com/technology/50031</link><description><![CDATA[Overview


The use of electrochemical impedance spectroscopy (EIS) to carry out real-time observations of cells and extract information about their physiological properties has expanded in recent years. The ease of integrating EIS with microfluidic devices has allowed the technology to further expand into biomedical research. We have developed a 64X64 sensing array, with 10&mu;m pixels in 180nm CMOS, that supports switching frequencies up to 100MHz.

Market Opportunity

Capacitive sensing and EIS are appealing technologies for miniaturized and integrated biochemical and cellular measurement sy...]]></description><pubDate>Wed, 21 Dec 2022 15:14:48 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/50031</guid></item><item><title>Novel Chromogenic Beta-Lactamase Substrate for Diagnostic Biomaterials</title><caseId>2569</caseId><link>http://brown.technologypublisher.com/technology/48855</link><description><![CDATA[Overview

Chromogenic beta-lactamase substrates are used to diagnose bacterial infections. Yet those currently available lose their diagnostic color-change capability when chemically modified. We have synthesized a novel chromogenic beta-lactam molecule (&ldquo;ANT&rdquo;) that retains its color-change response when modified for conjugation to a range of polymers.

Market Opportunity

Antibiotic-resistant bacteria such as MRSA are becoming one of the most serious medical threats facing the world. Rapid detection is critical, as many deaths are at least partially due to incorrect antibiotic pre...]]></description><pubDate>Mon, 21 Nov 2022 13:06:00 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48855</guid></item><item><title>Identification of Smurf2 as an HIF-1α–Degrading E3 Ubiquitin Ligase</title><caseId>3109</caseId><link>http://brown.technologypublisher.com/technology/48753</link><description><![CDATA[Overview

In cancer, hypoxia-inducible factor-1 (HIF-1) signaling promotes vascularization, increasing oxygen supply and facilitating the survival of malignant cells. It is also involved in metabolism alteration, immune evasion, cell invasion, and metastasis. We have determined that SMAD-specific E3 ubiquitin protein ligase 2 (Smurf2) reduces the stability of HIF-1&alpha; (the alpha subunit of HIF-1). This discovery of a new mechanism by which HIF-1&alpha; is regulated improves the under-standing of HIF-1&alpha; modulation in cancer cells and provides a path to the development of methods for t...]]></description><pubDate>Tue, 01 Nov 2022 15:07:19 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48753</guid></item><item><title>Anti-malarial drugs targeting PfGARP</title><caseId>3085J</caseId><link>http://brown.technologypublisher.com/technology/48752</link><description><![CDATA[Overview

Plasmodium falciparum malaria is a leading cause of morbidity and mortality in developing countries, infecting hundreds of millions of individuals and killing more than 300,000 children each year. Certain parasite strains are resistant to all anti-malarial drugs, and the anti-malarial drug discovery pipeline is alarmingly limited. We have developed small molecule drugs for the treatment of malaria that target P. falciparum glutamate-acid-rich protein (PfGARP).

&nbsp;Market Opportunity

P. falciparum, the most severe form of malaria, is responsible for the majority of deaths associat...]]></description><pubDate>Tue, 01 Nov 2022 15:02:06 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48752</guid></item><item><title>Low-Noise Amplifier for High-Speed Tunneling-Recognition Diagnostics</title><caseId>2336</caseId><link>http://brown.technologypublisher.com/technology/48750</link><description>Overview

Though optical and mechanical nanosensors may operate near their intrinsic noise floors, electronic platforms often plateau at limits determined jointly by the sensors and their electronic acquisition circuits. We have invented a low-noise method for the detection and determination of biomolecules obtained from high-speed electron-tunneling measurements.

Market Opportunity

Single biomolecules are faster, weaker, and more stochastic than their macroscale counterparts. Consequently, single-molecule measurements are constrained by poor signal-to-noise ratios, and temporal resolution i...</description><pubDate>Tue, 01 Nov 2022 11:20:01 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48750</guid></item><item><title>Responsive Hydrogel Systems to Regulate pH of Breast Cancer Tumor Microenvironment</title><caseId>3140</caseId><link>http://brown.technologypublisher.com/technology/48749</link><description>Overview

The acidification of cancer microenvironments is a well-known characteristic of solid tumors. Our novel hydrogel systems restore pH homeostasis by reducing pH levels within the tumor, thereby limiting drug resistance and metastasis.

Market Opportunity

Solid tumors grow faster than the blood supply to them, causing formation of a microenvironment within the tumor. This increases production of metabolic acids, decreasing pH levels outside the tumor cells while increasing pH levels inside the cells. Therefore, a potential strategy for treating cancer is to neutralize the pH in the tum...</description><pubDate>Tue, 01 Nov 2022 11:15:34 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48749</guid></item><item><title>MyCOVIDRisk Mobile App—A Novel Risk Estimation and Mitigation Tool</title><caseId>3089J</caseId><link>http://brown.technologypublisher.com/technology/48748</link><description><![CDATA[Overview

Launched in Oct. 2020, our publicly available MyCOVIDRisk mobile app has been accessed more than 1.3 million times, demonstrating high acceptance of a free and simple web-based mobile app to estimate and mitigate risk of SARS-CoV-19 transmission.

Market Opportunity

During the COVID-19 pandemic, the rapidly changing science and public health advice left the public wondering what their risk of infection was while taking part in everyday activities. There is a need for a simple, reliable way to assess, in real-time, one&rsquo;s risk of catching SARS-CoV-19 from everyday activities and...]]></description><pubDate>Tue, 01 Nov 2022 11:11:32 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48748</guid></item><item><title>Hyper-compliant polymer particles</title><caseId>2460</caseId><link>http://brown.technologypublisher.com/technology/48747</link><description>Overview

Polymer microbeads have been used extensively for biomedical applications, including device calibration, drug delivery, tissue engineering, and encapsulation of therapeutic agents. But their effectiveness is limited by the lack of microbeads that are similar to living cells. Our novel method is the first to produce polymer microbeads with size, stiffness, and spherical shape similar to those of typical mammalian cells.

Market Opportunity

Current methods for producing polymer microbeads for biomedical purposes do not result in microbeads with sizes and stiffnesses like those of livi...</description><pubDate>Tue, 01 Nov 2022 11:04:13 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48747</guid></item><item><title>Antibacterial and Antibiofilm Polyurethane Coating for Intravascular Catheters</title><caseId>2567J</caseId><link>http://brown.technologypublisher.com/technology/48746</link><description>Overview

Catheter-related bloodstream infections (CRBSIs) are a leading cause of hospital-acquired infections worldwide. Our auranofin-releasing antibacterial and antibiofilm polyurethane catheter coating kills bacteria and prevents them from forming hard-to-eliminate biofilms.

Market Opportunity

Intravascular catheters are used for hemodynamic monitoring, renal replacement therapy, nutritional support, and administration of medications. CRBSIs, a leading cause of hospital-acquired infections worldwide, are costly complications of intravascular catheter use. The catheter lumen can be contam...</description><pubDate>Tue, 01 Nov 2022 11:00:12 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48746</guid></item><item><title>SOCKS (Statistical Outlier Curation Kernel Software): A Modern, Efficient Tool for Outlier Detection and Curation</title><caseId>3108</caseId><link>http://brown.technologypublisher.com/technology/48743</link><description><![CDATA[Overview

Real-world signal acquisition through sensors is at the heart of the modern digital world, yet almost every signal acquisition system is contaminated with noise and outliers. Our data &ldquo;sanitizer&rdquo; tool provides a way to obtain uncorrupted observations.

Market Opportunity

It is increasingly evident that clarity of digital information is more important than volume of data. Data are often contaminated by background noise and outliers, which blur the underlying nature of the observed system. With the ever-growing volume of digital data, there is a critical need for a generic...]]></description><pubDate>Tue, 01 Nov 2022 09:46:57 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48743</guid></item><item><title>System for facilitating Speech-Based Communication for Individuals Unable to Speak or Write</title><caseId>2605J</caseId><link>http://brown.technologypublisher.com/technology/48742</link><description><![CDATA[Overview


Our novel communication system enables patients unable to speak or write to communicate with others in real time, through a motion-controlled wireless device.

Market Opportunity

The use of non-speech communication is important in certain health care situations when a patient is unable to communicate through speech. Examples are when a patient is intubated, undergoing treatment for an orofacial injury, or has a tracheotomy with mechanical ventilation but does not yet have the lung capacity to use a Passy-Muir (&ldquo;speaking&rdquo;) valve. The patient also may not have the cogniti...]]></description><pubDate>Tue, 01 Nov 2022 09:40:29 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48742</guid></item><item><title>Potential new targets for ALS</title><caseId>2372</caseId><link>http://brown.technologypublisher.com/technology/48647</link><description>Overview

Amyotrophic lateral sclerosis (ALS) is a devastating disease that is progressive, invariably fatal, and untreatable. Our invention features isolated Cyp4gl polypeptides with mutations at various key amino acid positions that suppress the effects and progress of ALS, as well as mutated polynucleotides that encode these polypeptides. Our invention also includes methods for treating ASL by administering a pharmaceutical or nutraceutical composition comprising one or more lipids.

Market Opportunity

Mutations in many genes with a wide range of functions and proposed mechanisms can cause...</description><pubDate>Wed, 19 Oct 2022 12:38:21 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48647</guid></item><item><title>𝜷‐Lactamase-Responsive Degradable Hydrogels</title><caseId>3032</caseId><link>http://brown.technologypublisher.com/technology/48639</link><description><![CDATA[&shy;Overview

Antibiotic-resistance poses a serious public health problem. We have developed a hydrogel (hydrated polymer network) that is sensitive to &beta;-lactamases, a class of enzymes released by a variety of harmful bacteria. In the presence of &beta;-lactamases, the hydrogel degrades, releasing the therapeutic agent it contains.

Market Opportunity

The emergence and rapid spread of antibiotic-resistant bacteria has caused serious public health and environmental issues worldwide. The growing use of &beta;‐lactam antibiotics in particular, has led to the rapid development of &beta;‐lac...]]></description><pubDate>Mon, 17 Oct 2022 16:15:33 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48639</guid></item><item><title>Bacteria Responsive Antibiofilm Polymer Nanoparticles</title><caseId>3193</caseId><link>http://brown.technologypublisher.com/technology/48638</link><description><![CDATA[&shy;Overview

Biofilm infections are common and difficult to treat. Nanoparticles that respond to multiple bacterial stimuli have the potential to successfully prevent and eradicate biofilms. We have developed a hyaluronic acid- and chitosan-coated, antibiotic-loaded gelatin nanoparticle that effectively combats bacterial biofilms.

Market Opportunity

Bacterial biofilms are clusters of bacteria embedded in self-produced matrixes of extracellular polymeric substances (EPS) that protect the bacteria and contribute to antimicrobial resistance. These biofilms are difficult to treat with conventi...]]></description><pubDate>Mon, 17 Oct 2022 16:08:14 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48638</guid></item><item><title>Novel Electrical Device to Dissociate Tissue Sections into Single Cells for Downstream Single-Cell Analysis</title><caseId>3076</caseId><link>http://brown.technologypublisher.com/technology/48637</link><description>Overview

Single-cell analysis is an important analytical tool for studying heterogeneous cellular populations, such as cancer tissues, where rare mutations can drive metastasis and treatment response outcome. A major limitation of the clinical translation of single-cell analysis is the difficulty of isolating single cells from complex tissues. Our novel method of electrical tissue dissociation has a variety of benefits, including its suitability to production, miniaturization, and time reduction. 

Market Opportunity

Dissociation of tissues into a suspension of single cells frequently involv...</description><pubDate>Mon, 17 Oct 2022 16:02:48 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48637</guid></item><item><title>Placental lipid bilayer for cell-free molecular interaction studies</title><caseId>3002</caseId><link>http://brown.technologypublisher.com/technology/48636</link><description><![CDATA[&shy;Overview

Researchers and clinicians have a need for in vitro or in vivo tools to quantify placental interactions at the molecular scale. Lipid bilayers have been used to model biological interfaces, including those in the liver, red blood cells or myelin.&nbsp; We have developed a lipid bilayer that mimics the lipid composition of the placenta.

&nbsp;Market Opportunity

Placental dysfunction is associated with increased perinatal and neonatal mortality and lifelong health complications in the mother and child. Yet the placenta remains one of the least understood organs in the human body...]]></description><pubDate>Mon, 17 Oct 2022 15:55:01 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48636</guid></item><item><title>Advanced Photonics for Brain Imaging with High Spatiotemporal Resolution</title><caseId>2601</caseId><link>http://brown.technologypublisher.com/technology/48635</link><description><![CDATA[&shy;Overview

We have developed a new type of noninvasive mobile neurotechnology that enables extremely sensitive, accurate, and high-resolution brain imaging.

Market Opportunity

Brain imaging has long been restricted to clinical and other specialized centers, mainly because of the large, complex, and expensive equipment required. Yet, to truly understand human brain function requires more than brief brain-imaging sessions in immobile subjects. A low-cost, long-duration, mobile brain-imaging technology would not only benefit neuroscience research, but have multiple clinical applications, in...]]></description><pubDate>Mon, 17 Oct 2022 15:47:36 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48635</guid></item><item><title>Bespoke Collagen Microfiber Scaffolds for Tissue Engineering</title><caseId>2591</caseId><link>http://brown.technologypublisher.com/technology/48634</link><description><![CDATA[&shy;Overview

In tissue engineering, cells are generally grown on a scaffold that emulates the cellular environment in the body. Together, the scaffold and cells can be implanted in a patient or serve as a testing platform, for example, to evaluate pharmaceuticals and toxicants. We have developed an accessible, low-cost, and automated method of preparing collagen microfibers, organizing the fibers into precisely controlled mesh designs, and embedding the tissues in a bulk hydrogel to create a composite biomaterial suitable for a wide variety of tissue engineering and regenerative medicine app...]]></description><pubDate>Mon, 17 Oct 2022 15:39:50 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48634</guid></item><item><title>Wireless Neural Probe to Communicate with Distributed Nodes</title><caseId>2555</caseId><link>http://brown.technologypublisher.com/technology/48633</link><description>Overview

Until now, neural probes required a full-device ecosystem to support probe communication, which limited the development of useful designs. Our invention uses near-field wireless communication and a flexible system architecture to simultaneously access multiple brain regions, allowing neuroscientists and clinicians to mix and match probes. 

Market Opportunity

The nervous system is a complex network of functionally connected groups of cells. However, commercially available technologies struggle to probe these connected sub-domains with single-cell resolution. Despite recent innovatio...</description><pubDate>Mon, 17 Oct 2022 15:34:30 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48633</guid></item><item><title>Commanding Electronic Devices from Discrete Neural Gestures</title><caseId>3179J</caseId><link>http://brown.technologypublisher.com/technology/48624</link><description><![CDATA[&shy;Overview

We have developed a brain-machine interface for control of computers and other electronic devices through natural but virtual (imagined) gestures. A multistate discrete decoder detects neural activity evoked from natural hand gestures and maps them to commands for computer interaction.

&nbsp;Market Opportunity

Emerging brain-computer interface (BCI) technology&nbsp;offers the possibility of building new artificial links between the nervous system and the external world for the clinical population living with neuromotor diseases. Neural activity related to upper limb motion has...]]></description><pubDate>Sat, 15 Oct 2022 15:10:09 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48624</guid></item><item><title>Inhibition of FTO with Entacapone to Treat Glioblastoma</title><caseId>3126J</caseId><link>http://brown.technologypublisher.com/technology/48623</link><description><![CDATA[Overview

Glioblastoma is one of the most aggressive and lethal human tumors. We are investigating the use of an FDA-approved drug, Entacapone, to treat glioma tumors.

&nbsp;Market Opportunity

Glioblastoma, one of the most aggressive forms of cancer, has a survival rate of only 14&ndash;15 months after diagnosis. There is an urgent need for effective therapies for glioblastoma.

&nbsp;Innovation and Meaningful Advantages

Glioblastoma&rsquo;s lethality is due to the presence of tumor propagating GSCs, which are characterized by the ability to self-renew, proliferate indefinitely, and potenti...]]></description><pubDate>Sat, 15 Oct 2022 14:40:08 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48623</guid></item><item><title>HDAC-7 as novel therapeutic target for human glioblastoma</title><caseId>3125J</caseId><link>http://brown.technologypublisher.com/technology/48622</link><description><![CDATA[Overview

Glioblastoma is one of the most aggressive and lethal human tumors. We have identified histone deacetylase 7 (HDAC-7) as a potential therapeutic target, a crucial first step toward development of an effective treatment for glioblastoma. 

&nbsp;Market Opportunity

Glioblastoma is the most malignant and aggressive primary brain tumor, with a survival rate of only 14&ndash;15 months after diagnosis. The treatment resistance and inevitable tumor recurrence are attributed mainly to the presence of tumor-initiating cells or glioma stem cells, which are characterized by the ability to self...]]></description><pubDate>Sat, 15 Oct 2022 14:23:36 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48622</guid></item><item><title>­​​​​​​​Metabolite Treatments for Metabolic Dysfunction and Neurological Disease Caused by Mutations in Mitochondrial Enzyme GPT2</title><caseId>3040</caseId><link>http://brown.technologypublisher.com/technology/48604</link><description><![CDATA[&nbsp;

Overview

The mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2) is necessary for metabolic mechanisms central to neuronal survival and axonal growth. Having demonstrated that loss-of-function mutations in GPT2 cause neuronal vulnerabilities involved in a variety of brain diseases and areas of brain function, we have developed a metabolite treatment for GPT2 disease and related clinical problems.

Market Opportunity

Diseases caused by loss-of-function mutations in GPT2 include GPT2 disease and motor diseases such as amyotrophic lateral sclerosis (ALS), while areas of brain ...]]></description><pubDate>Wed, 12 Oct 2022 07:40:27 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48604</guid></item><item><title>Proprietary targeting of Oligonucleotide to vulnerable splicing events to efficiently silence genes</title><caseId>3035</caseId><link>http://brown.technologypublisher.com/technology/48603</link><description><![CDATA[&nbsp;

Overview

The principle of antisense technology is the sequence-specific binding of an antisense oligonucleotide (ASO) to target mRNA and prevent gene translation. We have found the individual events that are most vulnerable to disruption in cancer cells and developed a method to target these events. We can further restrict the points of vulnerability to genes that are presumably more important to cancer cells than to the healthy cells of origin. 

Market Opportunity

There are 20 million new cancer cases and 10 million deaths from cancer globally every year. ASOs have recently shown g...]]></description><pubDate>Wed, 12 Oct 2022 07:24:52 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/48603</guid></item><item><title>Teaching Robots to Draw</title><caseId>2584</caseId><link>http://brown.technologypublisher.com/technology/47992</link><description><![CDATA[Overview

Modern robotic arms have been trained to mimic the motions of the human arm to perform tasks humans would otherwise need to do. This includes industrial robots that were created to handle radioactive or biohazardous waste that would be dangerous for humans to touch, as well as robots built to manipulate objects in warehouses or factories.&nbsp;

However, one of the more delicate operations humans perform with their fingers and arms&mdash;writing and drawing&mdash;has proven difficult for robots to replicate. Stefanie Tellex has demonstrated the invention of a robotic arm that can stu...]]></description><pubDate>Tue, 09 Aug 2022 10:48:46 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/47992</guid></item><item><title>A novel optical method for accurate blood oxygenation measurements independent of skin tone and other skin contributions</title><caseId>3175</caseId><link>http://brown.technologypublisher.com/technology/47984</link><description><![CDATA[Overview

Blood oxygen monitors have become a common sight during the COVID-19 pandemic, as oxygen depletion in the bloodstream can be a warning sign of infection. Often placed onto a patient&rsquo;s fingertip, these monitors rely on established photoplethysmography (PPG) technology which shines light on the skin and measures changes in how much of the light is absorbed to detect changes in blood oxygenation.

&nbsp;

However, numerous studies have shown that these pulse oximeters are inaccurate when used on patients with darker skin tones, creating the potential for problematic false negative...]]></description><pubDate>Mon, 08 Aug 2022 12:48:57 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/47984</guid></item><item><title>System and Method for Measuring Distribution of Deformation Using Atomic Force (not leading)</title><caseId>2172J</caseId><link>http://brown.technologypublisher.com/technology/47931</link><description><![CDATA[Interferometric absolute and real-time surface curvature sensor insensitive to tilt, translation and vibration


Overview



Kyung-Suk Kim has developed a device to improve modern microscopes by allowing them to measure deformations in a surface at the resolution of mere atoms. The invention can improve the resolution of an atomic micrograph system beyond the capabilities of state-of-the-art technologies including tunneling electron microscopes (TEM) and scanning probe microscopes (SPM).&nbsp;The device can measure deformation at an atomic scale with low expense by improving resolution using a...]]></description><pubDate>Wed, 03 Aug 2022 20:33:38 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/47931</guid></item><item><title>Giant Spin Hall Effect and Spin-Transfer-Torque Induced Switching in W/CoFeB/MgO with Perpendicular Magnetic Anisotropy</title><caseId>2322</caseId><link>http://brown.technologypublisher.com/technology/47930</link><description><![CDATA[&shy;Giant Spin Hall Effect in Beta-Tungsten


Overview



Our invention uses a compound that mimics a natural peptide or protein, called a peptidomimetic compound, to treat neuronal injury. Administered prophylactically as soon as possible after injury, the compound is particularly effective in the case of stroke, traumatic brain injury (TBI), and spinal cord injury. It may also aid treatment or prevention of the pathologic metabolic cascades associated with stroke and TBI, as well as retinal damage from glaucoma. The compound also has potential as a treatment for macular degeneration. 

&nbs...]]></description><pubDate>Wed, 03 Aug 2022 19:46:58 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/47930</guid></item><item><title>A magnetic gradiometer device based on magnetic tunneling junctions for use in detection and measurement of structural integrity, inhomogeneities, and magnetic properties of magnetic materials including magnetic cement over large standoff distances</title><caseId>3075J</caseId><link>http://brown.technologypublisher.com/technology/47922</link><description>Magnetic Gradiometer Device Based on Magnetic Tunneling


Overview



Nondestructive testing (NDT) is widely used in industry for noninvasive inspection, diagnosis, and evaluation of materials for defects. Our novel magnetic gradiometer can be used for detection and measurement of structural integrity, inhomogeneities, and magnetic properties of magnetic materials, including magnetic cement, over large standoff distances. Its state-of-the-art magnetic tunneling junction sensors offer high performance, high temperature operation, and a fabrication process compatible with silicon circuit technol...</description><pubDate>Wed, 03 Aug 2022 11:13:27 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/47922</guid></item><item><title>Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders</title><caseId>3167J</caseId><link>http://brown.technologypublisher.com/technology/47524</link><description><![CDATA[&shy;Salivary Extracellular Vesicles as Biomarkers for Alzheimer&#39;s Disease and Related Disorders
&nbsp;
Overview
Early diagnosis of Alzheimer&rsquo;s Disease (AD) and related disorders has historically been hampered by lack of readily accessible biomarkers. We have identified biomarkers present in the saliva that can distinguish between individuals with mild AD and normal controls.
&nbsp;
Market Opportunity
Alzheimer&#39;s disease (AD) and other dementia‐causing neurodegenerative disorders such as frontotemporal dementia (FTD), Parkinson&#39;s disease (PD), dementia with Lewy bodies (DLB),...]]></description><pubDate>Thu, 30 Jun 2022 14:17:47 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/47524</guid></item><item><title>A novel technology-augmented intervention to prevent peer violence and depressive
symptoms among at-risk emergency department adolescents iDove2 Intervention Protocol (Adolescent)</title><caseId>3142J</caseId><link>http://brown.technologypublisher.com/technology/47057</link><description><![CDATA[&shy;Digital Health Intervention to Improve Well-Being and Reduce Depression Among Adolescents Seen in Emergency Department

&nbsp;
Overview
Depressive symptoms and related problems are increasingly common among American youth. Yet no one has developed a mobile app that provides accessible, effective prevention interventions that teens will actually use. We have developed a digital intervention, iDOVE (intervention for DepressiOn and Violence prevention in the ED), that has been shown to increase well-being, decrease stress, and improve self-efficacy.
&nbsp;
Market Opportunity
At the same time...]]></description><pubDate>Thu, 02 Jun 2022 19:33:23 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/47057</guid></item><item><title>Intervention to Prevent Adolescent Cyber-victimization through App-messaging  (IMPACT)</title><caseId>3090J</caseId><link>http://brown.technologypublisher.com/technology/47056</link><description><![CDATA[&shy;Digital Health Intervention to Improve Well-being and Reduce Cyberbullying Among Adolescents

&nbsp;
Overview
Cyberbullying and depressive symptoms are increasingly common, interrelated problems among American youth; COVID has only heightened the reliance of youth on social media, as well as their mental distress. Our novel two-part app-based cybervictimization intervention for adolescents aged 13&ndash;17 decreases psychological stress, while increasing overall well-being and bystander actions.&nbsp;
&nbsp;
Market Opportunity
Up to 70 percent of adolescents report being a victim of cyber...]]></description><pubDate>Thu, 02 Jun 2022 19:20:22 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/47056</guid></item><item><title>New use of CsA-type drugs for the prevention and treatment of neurodegenerative
disorders, including Alzheimer’s disease</title><caseId>3144</caseId><link>http://brown.technologypublisher.com/technology/46539</link><description><![CDATA[&shy;Novel Method Repurposes CsA-Type Compounds to Treat Neurodegenerative Disease
&nbsp;
Overview
Alzheimer&rsquo;s disease remains a challenging disorder for drug development, with many candidate drugs failing clinical trials. Our novel method repurposes camphorsulfonic acid (CsA)-type compounds to treat early-stage Alzheimer&rsquo;s disease, as well as other neurodegenerative disorders, by inhibiting calcineurin, which affects signaling cascades linked to neurodegeneration and cognitive decline.
&nbsp;
Market Opportunity
According to the CDC, in 2020 an estimated 5.8 million Americans 65 or...]]></description><pubDate>Fri, 29 Apr 2022 08:21:40 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/46539</guid></item><item><title>Selenopropyl Silicon Gel and Highly Efficient Metal Scavenger</title><caseId>2133</caseId><link>http://brown.technologypublisher.com/technology/46042</link><description><![CDATA[&shy;

Selenopropyl Silicon Gel and Highly Efficient Metal Scavenger

&nbsp;
Overview
A variety of industries and applications, from the processing of radioactive waste to the development of new pharmaceutical drugs, would benefit greatly from a more sophisticated way to remove or scavenge certain metal ions from a material. Yongsong Huang and colleagues have developed a method for using a selenium-containing medium to achieve that goal. Their invention has the potential to refine the process of chromatography, the standard practice for separating a mixture of materials into its constituent el...]]></description><pubDate>Tue, 15 Mar 2022 06:33:38 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/46042</guid></item><item><title>Cyber-Physical System for Wind and Hydrokinetic Energy Conversion</title><caseId>2205</caseId><link>http://brown.technologypublisher.com/technology/46006</link><description><![CDATA[&shy;Cyber-Physical system for Wind and Hydrokinetic Energy Conversion

&nbsp;
Overview
Hydrokinetic tidal energy, which uses the energy of flowing water to turn turbines, is an important form of renewable energy. However, the turbines used must be custom-designed to work with the water conditions of their particular location. Their bespoke design is difficult to adapt to changing environmental conditions. Breuer and his team have developed a way to build a system that measures and adjusts to the changing water flow conditions to maintain optimum efficiency.&nbsp;
&nbsp;
Market Opportunity
In ...]]></description><pubDate>Wed, 02 Mar 2022 07:59:44 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/46006</guid></item><item><title>Combinatorial use of markers to isolate synaptic glia to generate synapses in a dish for
high-throughput and high-content drug discovery and testing</title><caseId>3050</caseId><link>http://brown.technologypublisher.com/technology/45998</link><description><![CDATA[&shy;Platform for in vitro Analysis of Synaptic Glia and Neuromuscular Synapses

&nbsp;
Overview
Novel in vitro technology to isolate and analyze the glial cells that form neuromuscular synapses will make it easier to discover and test drugs for conditions that affect peripheral nerves and skeletal muscles, such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, muscular dystrophy, and Guillain-Barre syndrome.
&nbsp;
Market Opportunity
The synaptic glia (also called perisynaptic Schwann cells) are critical components of neuromuscular junctions&mdash;the synapses between the motor...]]></description><pubDate>Mon, 28 Feb 2022 10:50:09 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45998</guid></item><item><title>Development and Use of a High-Throughput Screen to Identify Novel Modulators of the Corticotropin Releasing Factor Binding Protein</title><caseId>2579</caseId><link>http://brown.technologypublisher.com/technology/45963</link><description><![CDATA[&shy;Development of a HT Screen to Identify Novel Modulators of the CRFBP

&nbsp;
Overview
A connection between the corticotropin signaling pathway and alcohol use disorder (AUD) has been shown previously. We developed a high throughput screen to identify small molecule modulators of this pathway as potential therapeutics for AUD.
&nbsp;
Market Opportunity
Currently available treatments for alcohol use disorder (AUD) include three pharmacotherapies approved by the Food and Drug Administration: disulfiram, naltrexone, and acamprosate. The clinical efficacy of these pharmacotherapies is marginal...]]></description><pubDate>Tue, 22 Feb 2022 12:54:26 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45963</guid></item><item><title>Small molecule CB002 and its analogs restore the p53 pathway and target an S-phase checkpoint</title><caseId>3049</caseId><link>http://brown.technologypublisher.com/technology/45961</link><description><![CDATA[&shy;Novel Class of Small Molecules Restores Important p53 Pathway

&nbsp;
Overview
Approximately 50% of human cancers involve mutations in the tumor-suppressor gene p53, while the other 50% involve some type of inactivation on the p53 pathway. We have discovered a class of small molecules that restore the p53 pathway, as well as perturb an S-phase checkpoint.
&nbsp;
Market Opportunity
There are currently no FDA-approved drugs to restore the p53 pathway. Existing drugs are limited to ones that restore the mutant to wild-type p53 conformation, HSP90 inhibitors that target the mutant p53 protein...]]></description><pubDate>Tue, 22 Feb 2022 11:50:49 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45961</guid></item><item><title>Targeting enhancer RNAs (eRNA) for the treatment of primary brain tumors</title><caseId>3072J</caseId><link>http://brown.technologypublisher.com/technology/45959</link><description><![CDATA[&shy;Novel Therapeutic Approach for Glioblastoma

&nbsp;
Overview
Enhancer RNAs (eRNAs) are transcribed from active enhancer regions of the genome and function to increase the expression of target genes. The expression of specific eRNAs in glioma stem cells is correlated with decreased survival of patients with glioblastomas. Our novel technology uses synthetic oligonucleotides to target and knock out the expression of these eRNAs.
&nbsp;
Market Opportunity
Current treatment for glioblastomas includes surgical resection of the tumor mass followed by radiation and administration of temozolomide...]]></description><pubDate>Tue, 22 Feb 2022 11:43:45 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45959</guid></item><item><title>A novel nucleocytoplasmic regulator of autophagy-associated transcription factors stimulates autophagy and prevents the proteostatic decline associated with neurodegeneration</title><caseId>2469</caseId><link>http://brown.technologypublisher.com/technology/45958</link><description><![CDATA[&shy;Activating Autophagy to Prevent Neurodegeneration and Extend Lifespan
&nbsp;
Overview
Decline in proteostasis is a hallmark of age-related neurodegerative disease such as Alzheimer&rsquo;s Disease. Autophagy is the process by which cells rid themselves of damaged or otherwise unnecessary material, which then moves to the lysosome and degrades. Pharmacologic enhancement of autophagy could help treat or prevent age-related conditions.
&nbsp;
Market Opportunity
The current standard of care for Alzheimer&rsquo;s disease (AD) is largely inadequate as there are no effective treatments against t...]]></description><pubDate>Tue, 22 Feb 2022 11:40:17 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45958</guid></item><item><title>METHODS AND COMPOSITIONS FOR TREATING OBESITY BY OPSIN 3 REGULATION OF HYPOTHALAMIC MELANOCORTIN RECEPTORS</title><caseId>3014</caseId><link>http://brown.technologypublisher.com/technology/45957</link><description><![CDATA[&shy;Preventing and Treating Obesity through Opsin 3 Regulation of Hypothalamic Melanocortin Receptors

&nbsp;
Overview
Obesity is a worldwide health problem. The complex disease disrupts many body systems and reduces life expectancy. Our technology offers a safe, effective way to prevent and treat obesity and obesity-related disorders through opsin 3 regulation of hypothalamic melanocortin receptors.
&nbsp;
Market Opportunity
Achieving long-term weight loss through dietary restriction is generally ineffective. The two drugs approved by the FDA for the treatment of obesity cause serious side e...]]></description><pubDate>Tue, 22 Feb 2022 11:38:09 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45957</guid></item><item><title>Inhibition of Glycogen Synthase Kinase 3-beta (GSK3-b) with the small molecule 9-ING-41 stimulates Natural Killer and T cell activity, reduces vascular endothelial growth factor levels, and induces cancer cell death.</title><caseId>3107</caseId><link>http://brown.technologypublisher.com/technology/45882</link><description><![CDATA[&shy;Overview
In recent years, immune checkpoint blockade (ICB) has provided oncologists with a powerful new tool. But while ICB has been found to be effective in microsatellite instability-high (MSI-H) colorectal cancer, it is far less effective in microsatellite stable (MSS) colorectal cancer. We have developed glycogen synthase kinase-beta (GSK-3-b) inhibitors that are effective in cases of MSS colorectal cancer.
&nbsp;
Market Opportunity
Globally, among cancers, colorectal cancer ranks third in terms of incidence and second in terms of mortality. Treatment options include surgery, chemothe...]]></description><pubDate>Tue, 08 Feb 2022 14:07:21 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45882</guid></item><item><title>Implantable Wireless Network of Distributed Microscale Sensors for Neural Applications</title><caseId>2597J</caseId><link>http://brown.technologypublisher.com/technology/45452</link><description><![CDATA[&shy;Wireless Network of Neural Implants for Brain-Machine Interfaces

&nbsp;
Overview
The field of brain-machine interfaces has advanced significantly over the past two decades, especially in its successful transition into human clinical trials. This progress has relied largely on wired, invasive sensors for the acquisition of neural data with high spatial and temporal resolution. Our invention, which represents the first completely wireless network of sensors in neural application, consists of ensembles of implantable, sub-millimeter, individually addressable microchips, which we term &ldquo...]]></description><pubDate>Mon, 29 Nov 2021 10:51:46 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45452</guid></item><item><title>Adaptive, Wireless Microchiplet Network for Large Scale Cortical Sensing and Stimulation</title><caseId>2563J</caseId><link>http://brown.technologypublisher.com/technology/45451</link><description><![CDATA[Wireless Network of Neural Implants for Brain-Machine Interfaces

&nbsp;
Overview
The field of brain-machine interfaces has advanced significantly over the past two decades, especially in its successful transition into human clinical trials. This progress has relied largely on wired, invasive sensors for the acquisition of neural data with high spatial and temporal resolution. Our invention, which represents the first completely wireless network of sensors in neural application, consists of ensembles of implantable, sub-millimeter, individually addressable microchips, which we term &ldquo;neur...]]></description><pubDate>Mon, 29 Nov 2021 10:51:01 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45451</guid></item><item><title>HIGH RESOLUTION X-RAY DETECTOR SYSTEM</title><caseId>3020</caseId><link>http://brown.technologypublisher.com/technology/45450</link><description><![CDATA[&shy;Overview
An x-ray detector is only as good as its image resolution. Our technology, which uses coherent bundles of scintillating fibers, provides a substantial increase in resolution over existing x-ray detector technologies.

Market Opportunity
The usefulness of x-ray imaging&rsquo;s many medical applications is limited by the image resolution. The x-rays currently used for mammography, for example, are 80&ndash;100 microns. The less than 10-micron resolution of x-rays produced with our technology greatly improves the ability to discern malignancies. The greater resolution produced by ou...]]></description><pubDate>Mon, 29 Nov 2021 10:46:39 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45450</guid></item><item><title>Ultrasensitive magnetic sensors using magnetic tunneling junctions incorporated with multiple stages of magnetic flux concentrators</title><caseId>2577</caseId><link>http://brown.technologypublisher.com/technology/45372</link><description><![CDATA[&shy;Ultrasensitive Magnetic Tunneling Junction Sensor

&nbsp;
Overview
The sensitivity of current magnetic sensors is often inadequate. Our novel technology incorporates an on-chip magnetic flux concentrator (onMFC) and an external magnetic flux concentrator (exMFC) on a magnetic tunneling junction sensor placed on a silicon wafer. These double-staged MFCs have an amplification factor of 517.
&nbsp;
Market Opportunity
Magnetic tunneling junctions, which allow for smaller, thinner, faster, and more cost-effective devices, have many potential uses, including memory devices and analog-to-digital...]]></description><pubDate>Mon, 15 Nov 2021 08:46:49 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45372</guid></item><item><title>Plasmonic Interferometry Cytokine Detection</title><caseId>2048</caseId><link>http://brown.technologypublisher.com/technology/45224</link><description><![CDATA[&shy;Plasmonic Interferometry Cytokine Detection

&nbsp;
Overview
Optical interferometry is a valuable tool in fields ranging from fiber optics and biomedical imaging to astronomy. Plasmonics interferometry, which enables the guiding and manipulation of light in devices much smaller than the wavelength of the incident light, makes use of the ability of metal nanostructures to manipulate light at the nanoscale. Our system of plasmonic interferometry enables high-throughput, real-time detection of analytes in fluids, such as glucose in saliva.
&nbsp;
Market Opportunity
Current interferometry scr...]]></description><pubDate>Mon, 01 Nov 2021 13:26:50 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45224</guid></item><item><title>Geometry Character Recognition System</title><caseId>2177</caseId><link>http://brown.technologypublisher.com/technology/45222</link><description><![CDATA[Synchronizing Virtual and Physical Models for Industrial Shape Design

Overview
Engineers and designers often work with both virtual and physical models of the object they are creating. However, if they modify the physical model of their design in order to change or improve its function, they must make the same changes to the virtual design or the two will be out of sync. This technology allows the designer to take a 3D scan of the physical model that automatically updates and synchronizes it with the designer&rsquo;s virtual model.&nbsp;

Market Opportunity
Industrial designers work with both...]]></description><pubDate>Mon, 01 Nov 2021 11:45:34 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45222</guid></item><item><title>ndial</title><caseId>2267</caseId><link>http://brown.technologypublisher.com/technology/45221</link><description><![CDATA[ndial: A System for Electronically Generating Music

Overview
Electronic musical instruments such as a synthesizer can create new kinds of sounds that would be unlikely or impossible to make with an acoustic instrument such as a violin, drum, or piano. However, most electronic instruments are controlled by a keyboard or other kind of conventional input device. The ndial is a tactile tool that allows people with any level of musical experience&mdash;including none&mdash;to experiment with new sounds and musical forms. &nbsp;

Market Opportunity
Consider a modern instrument like the synthesizer....]]></description><pubDate>Mon, 01 Nov 2021 11:43:52 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45221</guid></item><item><title>Peel-Away Electrode Placement Catheter for Deep Brain Stimulation (DBS)</title><caseId>2548J</caseId><link>http://brown.technologypublisher.com/technology/45218</link><description><![CDATA[&shy;Brown&rsquo;s Laboratory for Neurophysiology and Neuromodulation&nbsp;

&nbsp;
The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design improved methods of neurophysiological biomarker detection and more effective forms of brain modulation. One of the ultimate goals of the lab is to transform the techniques of neuromodulation such that treatment can be customized to the...]]></description><pubDate>Mon, 01 Nov 2021 09:37:54 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45218</guid></item><item><title>Continuous motor task for objectively quantifying motor symptoms in movement disorders</title><caseId>2565J</caseId><link>http://brown.technologypublisher.com/technology/45217</link><description><![CDATA[&shy;Brown&rsquo;s Laboratory for Neurophysiology and Neuromodulation&nbsp;

&nbsp;
The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design improved methods of neurophysiological biomarker detection and more effective forms of brain modulation. One of the ultimate goals of the lab is to transform the techniques of neuromodulation such that treatment can be customized to the...]]></description><pubDate>Mon, 01 Nov 2021 09:36:17 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/45217</guid></item><item><title>Novel Antibacterial Compounds Avoid Microbial Resistance</title><caseId>2365J</caseId><link>http://brown.technologypublisher.com/technology/44868</link><description><![CDATA[Novel Antibacterial Compounds Avoid Microbial Resistance

Overview
According to the Centers for Disease Control&rsquo;s Antibiotic Resistance Threats in the United States, 2019, more than 2.8 million antibiotic-resistant infections occur in the United States each year, and more than 35,000 people die as a result. Thus there is an urgent need for new ant-bacterial compounds that meet minimal or no resistance build-up. Our invention consists of novel antibacterial diamide compounds, and methods for using the compounds, to treat and prevent bacterial infection.

Market Opportunity
Numerous antiba...]]></description><pubDate>Tue, 07 Sep 2021 08:53:41 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/44868</guid></item><item><title>X-ray Imaging with Micron Resolution</title><caseId>2286J</caseId><link>http://brown.technologypublisher.com/technology/44867</link><description><![CDATA[Novel Scintillating Detectors for X-ray Imaging with Micron Resolution

Overview
An x-ray detector is only as good as its image resolution. Our technology, which uses coherent bundles of scintillating fibers, provides a substantial increase in resolution over existing x-ray detector technologies.

Market Opportunity
The usefulness of x-ray imaging&rsquo;s many medical applications is limited by the image resolution. The x-rays currently used for mammography, for example, are 80&ndash;100 microns. The less than 10-micron resolution of x-rays produced with our technology will greatly improve the...]]></description><pubDate>Tue, 07 Sep 2021 08:45:42 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/44867</guid></item><item><title>Novel Shape-Memory Electrodes for Minimally Invasive Spinal Cord Stimulation and Recording</title><caseId>3101J</caseId><link>http://brown.technologypublisher.com/technology/44866</link><description>Novel Shape-Memory Electrodes for Minimally Invasive Spinal Cord Stimulation and Recording

Overview
Neuromodulation is a rapidly expanding field of clinical neuroscience. Yet the widespread use of neuronal probes for recording and functional stimulation has been slow to develop, in part because of incompatibility problems with existing metallic and ceramic probes, as well as surgical complexity and potential tissue damage or infection during probe insertion. Our technology is an electrode array made of shape-memory alloys and/or shape-memory polymers that can be inserted in a minimally invasi...</description><pubDate>Tue, 07 Sep 2021 08:43:58 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/44866</guid></item><item><title>Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases
 (Case 1939)</title><caseId>1939J</caseId><link>http://brown.technologypublisher.com/technology/44629</link><description><![CDATA[Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases

Overview
Stroke and other neurological insults entail a build-up of waste materials in brain cells. One of the most common waste materials is glutamate, which is present in more than 50 percent of nervous tissue. Glutamate receptors are critical to neuronal functioning. Failure to regulate these receptors contributes to various neurological disorders and to neurodegeneration diseases such as Alzheimer&#39;s, Parkinson&rsquo;s, and Huntington&rsquo;s. PDZ domains, amino acid chains which play a key role in signaling pro...]]></description><pubDate>Wed, 11 Aug 2021 04:45:53 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/44629</guid></item><item><title>Method to Predict and Diagnose Seizures and Other Neurological Events (Case 2045)</title><caseId>2045J</caseId><link>http://brown.technologypublisher.com/technology/42858</link><description><![CDATA[Method to Predict and Diagnose Seizures and Other Neurological Events

Overview
Though epilepsy is a common neurological disorder, the medical community still struggles to define and understand seizures and related neurological events. Our method uses implanted microelectrode arrays to predict and detect neurological events&mdash;a crucial first step toward being able to prevent and control them.&nbsp;

Market Opportunity
Because epilepsy is incurable, the ability to prevent epileptic seizures (and other neurological events) could profoundly affect the lives of millions of people. Our method e...]]></description><pubDate>Wed, 03 Feb 2021 06:41:38 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/42858</guid></item><item><title>Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)</title><caseId>2035</caseId><link>http://brown.technologypublisher.com/technology/41001</link><description><![CDATA[Robust, Stable, and &ldquo;Smart&rdquo; Microstructure Drug Delivery for Controlled Release

&nbsp;
Overview
Effective &ldquo;smart&rdquo; fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure &ldquo;smart&rdquo; delivery system for controlled release of therapeutics.
&nbsp;
Market Opportunity
Drug-eluting fibers can be woven into biotextiles for the release of numerous therapeutics with micron-scale accuracy; but only a small subset of polymer fibers is suitable for drug...]]></description><pubDate>Tue, 14 Jul 2020 14:31:55 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/41001</guid></item><item><title>Novel Therapeutic For Treating Brain Injury (Case 2118)</title><caseId>2118J</caseId><link>http://brown.technologypublisher.com/technology/39696</link><description><![CDATA[Novel Therapeutic for Treating Brain Injury

Overview
Our invention uses a compound that mimics a natural peptide or protein, called a peptidomimetic compound, to treat neuronal injury. Administered prophylactically as soon as possible after injury, the compound is particularly effective in the case of stroke, traumatic brain injury (TBI), and spinal cord injury. It may also aid treatment or prevention of the pathologic metabolic cascades associated with stroke and TBI, as well as retinal damage from glaucoma. The compound also has potential as a treatment for macular degeneration.&nbsp;
&nbsp...]]></description><pubDate>Tue, 28 Apr 2020 12:35:04 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39696</guid></item><item><title>Optogenetic Control of the Blood Brain Barrier for Drug Delivery (Case 2135)</title><caseId>2135J</caseId><link>http://brown.technologypublisher.com/technology/39695</link><description><![CDATA[Optogenetic Control of the Blood Brain Barrier for Drug Delivery

Overview
The blood&ndash;brain barrier (BBB) remains a significant impediment to drug development for central nervous system (CNS) disorders. Our novel method provides a way to regulate the permeability of the BBB, enabling delivery of therapeutics to the brain with high spatial and temporal precision. It can also be used to control vascular properties such as vascular tone, arterial diameter, and vascular growth.
&nbsp;
Market Opportunity
Though the BBB is crucial for normal brain function, in medical practice it is an obstacle...]]></description><pubDate>Tue, 28 Apr 2020 12:34:47 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39695</guid></item><item><title>Intracranial Fixation Device for Probes and Catheters (Case 2253)</title><caseId>2253J</caseId><link>http://brown.technologypublisher.com/technology/39694</link><description><![CDATA[Brown&rsquo;s Laboratory for Neurophysiology and Neuromodulation&nbsp;

&nbsp;
The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design improved methods of neurophysiological biomarker detection and more effective forms of brain modulation. One of the ultimate goals of the lab is to transform the techniques of neuromodulation such that treatment can be customized to the indi...]]></description><pubDate>Tue, 28 Apr 2020 12:33:53 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39694</guid></item><item><title>Trustworthy Cloud Computing (Case 2025)</title><caseId>2025J</caseId><link>http://brown.technologypublisher.com/technology/39693</link><description><![CDATA[Principal Investigator:&nbsp;Roberto Tamassia, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Cloud services are fast becoming a vital part of today&rsquo;s computing reality. Millions of online users manage their personal data through remote cloud storage and services such as Gmail and Google docs. Internet-based applications are offered and managed by third-party service providers such as Amazon S3, EC2 and SimpleDB Web services. As more end-user applications consume information that comes from unknown machines, verifying the integrity...]]></description><pubDate>Tue, 28 Apr 2020 12:32:54 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39693</guid></item><item><title>Improved Method of Manufacturing Nanowire Nanoarray Memories  (Case 1709)</title><caseId>1709J</caseId><link>http://brown.technologypublisher.com/technology/39692</link><description><![CDATA[Principal Investigator:&nbsp; John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on either side of a molecular layer.&nbsp; Molecules in the molecular layer are chosen that change their conductivity under the application of large positive and negative electric fields.&nbsp; The state of a switch at a crosspoint can...]]></description><pubDate>Tue, 28 Apr 2020 12:32:23 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39692</guid></item><item><title>Automated Microfluidic Cryo-TEM Sample Prep for Optimal Visualization (Case 1966)</title><caseId>1966J</caseId><link>http://brown.technologypublisher.com/technology/39691</link><description><![CDATA[Automated Microfluidic Blotless Specimen Preparation for Cryo-TEM

&nbsp;
Overview
Transmission electron microscopy (TEM) is an important imaging tool in many physical and biological scientific fields. Because current methods for preparing the thin TEM specimens are specific to the material being analyzed and the information being sought, many different methods are used. Our method for automatically preparing TEM specimens deposits extremely small samples onto a grid, doing away with the need for a blotting step and enabling images of previously unobserved structures.&nbsp;
&nbsp;
Market Oppor...]]></description><pubDate>Tue, 28 Apr 2020 12:31:59 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39691</guid></item><item><title>New Composition for Biologics (Case 2289)</title><caseId>2289J</caseId><link>http://brown.technologypublisher.com/technology/39553</link><description><![CDATA[Principal Investigator(s):&nbsp;Edith Mathiowitz, Ph.D.Professor of Medical Science and EngineeringDirector of the Graduate Program in Biotechnology&nbsp;Brown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;The market for protein/peptide-based therapeutics has become decidedly established in the past decade, although the gastrointestinal tract causes a significant drug-delivery challenge. As a consequence, most protein-based drugs must be delivered intravenously or subcutaneously.&nbsp;Brown University researchers have established a nanoparticle delivery system contained in a PEG/pluron...]]></description><pubDate>Tue, 14 Apr 2020 11:18:53 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39553</guid></item><item><title>Methylation Cytometry Diagnostic for Immuno-Oncology  (Case 2073)</title><caseId>2073J</caseId><link>http://brown.technologypublisher.com/technology/39514</link><description><![CDATA[Methylation Cytometry Diagnostic for Immuno-Oncology

&nbsp;
Overview
DNA methylation-based biomarkers have great potential to transform the diagnosis, monitoring, and treatment of cancer and other diseases. DNA methylation is an epigenetic mechanism used by cells to control gene expression. During DNA methylation, methyl groups are added to the DNA molecule, changing the DNA activity but not the sequence. Errors in methylation have been linked to a variety of diseases. Currently, clinicians use DNA methylation tests to screen for certain genetic changes that can affect processes such as methi...]]></description><pubDate>Wed, 08 Apr 2020 21:00:08 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39514</guid></item><item><title>Optimized, Cost Effective X-Ray Imaging that Rivals MRI:  
X-Ray Spatial Frequency Heterodyne Imaging with Protein-Based “Nanobubble” Contrast Agents</title><caseId>2292J</caseId><link>http://brown.technologypublisher.com/technology/39513</link><description><![CDATA[Principal Investigator:&nbsp;Christoph Rose-Petruck, PhD, ProfessorDepartment of ChemistryBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Spatial Frequency Heterodyne Imaging (SFHI) is a novel x-ray scatter imaging technique that utilizes nanoparticle contrast agents.&nbsp; Previous studies on SFHI have utilized only metal nanoparticle contrast agents such as gold.&nbsp; Indeed, the use of gold and iron oxide nanoparticle contrast agents has been proven to further enhance the sensitivity of SFHI with results demonstrating that SFHI is capable of distinguishing between cancer tissue...]]></description><pubDate>Wed, 08 Apr 2020 16:54:15 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39513</guid></item><item><title>Biological Pick, Place, and Perfuse "BioP3" - Device to Engineer Thick Living Tissues with High Cell Density (Case 2220) (EA)</title><caseId>2220J</caseId><link>http://brown.technologypublisher.com/technology/39503</link><description><![CDATA[Engineering Thick Living Tissues with High Cell Density&nbsp;

&nbsp;
Overview
The ability to build organs in vitro will have a far-reaching impact on the field of tissue engineering, as well as other areas of research that use animals. Cells cultured in 3D mimic native tissues and organs much more effectively than do those cultured in 2D. While significant advances have been made in the field of bioprinting, we are still far from creating fully functional organs. One common limitation is the inability to create thick structures with sufficient density of cells. Our novel device is able to eng...]]></description><pubDate>Tue, 07 Apr 2020 18:39:01 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39503</guid></item><item><title>Fast Detection of Hypervirulent Clostridium Difficile (Case 1952)</title><caseId>1952J</caseId><link>http://brown.technologypublisher.com/technology/39502</link><description><![CDATA[Fast Detection of Hypervirulent Clostridium Difficile

&nbsp;
Overview
When a patient presents with symptoms of Clostridium difficile (C. difficile), rapid determination of the toxicity of the strain is of paramount importance; if a hypervirulent strain is identified, it is important to begin appropriate antimicrobial therapy as quickly as possible. Our novel method, which uses a single reaction tube, radically improves the process of determining the toxicity of a C. difficile strain.
&nbsp;
Market Opportunity
C. difficile is a common cause of antibiotic-associated diarrhea, accounting for 15%...]]></description><pubDate>Tue, 07 Apr 2020 18:06:45 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39502</guid></item><item><title>Optimized, Cost Effective X-Ray Imaging that Rivals MRI:  X-Ray Scatter Imaging of Nanoparticle-Labeled Tissues for Early Cancer Detection (Case 2093)</title><caseId>2093J</caseId><link>http://brown.technologypublisher.com/technology/39501</link><description><![CDATA[Optimized, Cost Effective X-Ray Imaging that Rivals MRI

Overview
The most common form of liver cancer in adults, hepatocellular carcinoma (HCC) is difficult to detect in its early stages using existing technologies such as computed tomography (CT) or magnetic resonance imaging (MRI). Rose-Petruck&rsquo;s invention allows for the earlier detection of HCCs and other cancers via a novel use of x-rays. His technology involves the use of nanoparticles to label different kinds of tissues. He then measures how x-rays are scattered to identify tissues inside the body.
&nbsp;
Market Opportunity
Around...]]></description><pubDate>Tue, 07 Apr 2020 18:04:52 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39501</guid></item><item><title>Minimally-Invasive and Activity Dependent Control of Excitable Neurons (Case 2333)</title><caseId>2333J</caseId><link>http://brown.technologypublisher.com/technology/39428</link><description><![CDATA[Minimally Invasive Optogenetic Control of Excitable Neurons

&nbsp;
Overview
Optogenetics uses light to modulate excitable cells containing light-sensitive ion channels, known as opsins When activated by light, opsins cause depolarization or hyperpolarization of cell membranes, resulting in cellular excitation or silencing on a short time scale. &nbsp;Our minimally invasive bioluminescence-driven optogenetic technology could be used to treat a range of diseases and conditions in excitable cells, including those associated with bursting (brief periods of high-frequency action potential activity...]]></description><pubDate>Mon, 30 Mar 2020 16:38:31 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/39428</guid></item><item><title>Tunable Antimicrobial-Loaded Gellan Hydrogels for Burn Wound Dressings</title><caseId>2327</caseId><link>http://brown.technologypublisher.com/technology/24021</link><description><![CDATA[
Overview

The standard practice of treating burn wounds preventatively with broad-spectrum antibiotics contributes to the growing problem of antibiotic resistance. Exposure to systemic antibiotics also leads to toxicity in unaffected tissues. Using FDA-approved methods, we have developed a gellan hydrogel delivery system with tunable mechanical and drug-release properties for a wide variety of drug types and wound configurations.

&nbsp;

Market Opportunity

&nbsp;

In the US alone, infections in burn wounds affect approximately 100,000 patients each year and are the leading cause of death in...]]></description><pubDate>Fri, 10 Feb 2017 11:33:04 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/24021</guid></item><item><title>Electrochemical Reduction of CO2 at Copper Nanofoam Electrodes</title><caseId>2262</caseId><link>http://brown.technologypublisher.com/technology/20561</link><description><![CDATA[
Overview

There is currently a great deal of interest in CO2 reduction as a way to capture carbon and use it to make industrial chemicals, most of which are still being made from fossil fuels. We have invented a copper nanofoam electrocatalytic electrode that reduces CO2 10&ndash;20% more effectively than smooth electropolished copper electrodes.

&nbsp;

Market Opportunity

Copper is unique in its ability to catalyze the electrochemical conversion of CO2 to valuable fuels and chemicals. Though a variety of metallic electrodes have been investigated for the electrochemical reduction of CO2, m...]]></description><pubDate>Fri, 16 Oct 2015 12:41:58 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/20561</guid></item><item><title>New and Improved Antibacterial Compounds (Case 2062)</title><caseId>2062</caseId><link>http://brown.technologypublisher.com/technology/20129</link><description><![CDATA[Principal Investigator:&nbsp;Jason Sello, PhD, Assistant ProfessorDepartment of Chemistry&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp; Brown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Infectious diseases are the second leading cause of death &ndash; glob...]]></description><pubDate>Wed, 19 Aug 2015 07:42:15 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/20129</guid></item><item><title>Unbreakable Privacy in Cloud Computing</title><caseId>234</caseId><link>http://brown.technologypublisher.com/technology/18698</link><description><![CDATA[Portfolio of Novel Technologies Enable Trustworthy Cloud Computing by Non-forgeable Cryptographic Methods&nbsp;Data privacy.&nbsp; Users want it.&nbsp; Cloud services providers want to offer it.&nbsp; But can privacy be guaranteed with hard certainty?&nbsp; Now it can.&nbsp; Developed in the research lab of Roberto Tamassia, PhD, at Brown University, we present a series of novel technologies that enable cloud computing which customers can rely upon to have unbreakable data privacy. &nbsp;Cloud computing privacy presents several challenges associated with data storage and retrieval.&nbsp; Curre...]]></description><pubDate>Tue, 17 Mar 2015 07:21:13 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/18698</guid></item><item><title>Unbreakable Privacy in Cloud Computing</title><caseId>410</caseId><link>http://brown.technologypublisher.com/technology/18697</link><description><![CDATA[Portfolio of Novel Technologies Enable Trustworthy Cloud Computing by Non-forgeable Cryptographic Methods&nbsp;Data privacy.&nbsp; Users want it.&nbsp; Cloud services providers want to offer it.&nbsp; But can privacy be guaranteed with hard certainty?&nbsp; Now it can.&nbsp; Developed in the research lab of Roberto Tamassia, PhD, at Brown University, we present a series of novel technologies that enable cloud computing which customers can rely upon to have unbreakable data privacy. &nbsp;Cloud computing privacy presents several challenges associated with data storage and retrieval.&nbsp; Curre...]]></description><pubDate>Tue, 17 Mar 2015 07:15:21 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/18697</guid></item><item><title>Wearable Computer-Vision Rig for the Visually Impaired (Case 2241)</title><caseId>2241</caseId><link>http://brown.technologypublisher.com/technology/18485</link><description><![CDATA[Wearable Computer-Vision Rig for the Visually Impaired

&nbsp;
Overview
Brown University professor Benjamin Kimia, a leader in computer vision and image processing as well as artificial intelligence, has developed a wearable device that can help the visually impaired navigate indoor environments. Called BlindFind, the wearable rig uses cameras, object recognition algorithms, and motion-sensing technologies that are already common in consumer electronics. It marries them to a proprietary data set of navigation information about public indoor spaces such as government buildings, airports, and sc...]]></description><pubDate>Fri, 13 Mar 2015 11:17:32 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/18485</guid></item><item><title>Supergratings - Improved Detection and Processing of Optical Signals (Case 1466)</title><caseId>1466</caseId><link>http://brown.technologypublisher.com/technology/18235</link><description><![CDATA[Principal Investigator:&nbsp;Jingming Xu, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Gratings are optical devices used to achieve wavelength-dependent characteristics by means of optical interference effects.&nbsp; These wavelength-dependent optical characteristics can serve to reflect light of a specific wavelength while transmitting or refracting light at all other wavelengths.&nbsp; Such characteristics are useful in a wide range of situations including the extraction of individual wavelength-channels in wavelength division multiplexed (WD...]]></description><pubDate>Fri, 06 Feb 2015 11:06:36 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/18235</guid></item><item><title>Compounds to Treat and Prevent Viral Infections (Case 2165)</title><caseId>2165</caseId><link>http://brown.technologypublisher.com/technology/17650</link><description>Compound to Treat and Prevent Viral Infections

Overview
Polyomaviruses such as JC-polyomavirus (JCV) and BK-polyomavirus (BKV) are a common source of childhood and young adult infection. The majority of these infections cause little or no symptoms and are probably present in most adults. However, among people who are immunosuppressed as a result of AIDS, old age, or organ transplantation, these two polyomaviruses can cause severe disease. We have identified two small molecules that effectively target these polyomaviruses.

Market Opportunity
In immunosuppressed subjects, in particular, the po...</description><pubDate>Mon, 08 Dec 2014 08:41:58 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/17650</guid></item><item><title>Separation, Identification of Organic Compounds (Case 2013)</title><caseId>2013</caseId><link>http://brown.technologypublisher.com/technology/14463</link><description><![CDATA[Principal Investigator:&nbsp; Yongsong Huang, PhD, ProfessorDepartment of Geological Sciences Brown UniversityProvidence, RIBrief Description:&nbsp;This invention is a series of novel chromatographic materials for separating and identifying organic molecules and compounds.&nbsp; Highly useful in detections and analysis of environmental pollutants, pharmarceutical and food contaminants, this novel-chemistry makes available a new chromatographic medium with a high affinity and specificity to compounds having intramolecular p bonds (e. g., carbon-carbon double or triple bonds), and performs a hig...]]></description><pubDate>Sat, 08 Feb 2014 08:28:28 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/14463</guid></item><item><title>Screening Method for Inhibitors of Multidrug-Resistance Transporters (Case 2079)</title><caseId>2079</caseId><link>http://brown.technologypublisher.com/technology/10051</link><description><![CDATA[Novel Screening Method for Inhibitors of Multidrug-Resistant Transporters

&nbsp;
Overview
Drug transport is of fundamental importance to the efficacy and toxicity of all drugs. From the route of administration to the site of action, a drug encounters numerous biological barriers, including efflux pumps that pump drugs out of cells. Our novel method uses spheroidal models to screen for drugs that inhibit efflux pumps without blocking gap junctions in tumors; the selected drugs represent potential treatments for tumors.

Market Opportunity
Efflux pumps are transport proteins involved in extrudi...]]></description><pubDate>Thu, 16 Aug 2012 08:48:05 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/10051</guid></item><item><title>Advanced, Wireless, Implantable Neural Recording and Stimulation Microsystem (Case 2032)</title><caseId>2032</caseId><link>http://brown.technologypublisher.com/technology/9573</link><description><![CDATA[Principal Investigator:&nbsp;Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;With the advent of advanced materials, MEMs, microfluidics, nanotechnology and interdisciplinary research programs between engineering fields and the biomedical sciences, miniaturized, next generation devices are now being developed for implantation in the body for more effective, targeted monitoring and treatment of diseases, disorders, and injuries.&nbsp; A targeted treatment has fewer, if any, undesirable, peripheral side effects on normal cells, and oft...]]></description><pubDate>Wed, 20 Jun 2012 05:29:41 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/9573</guid></item><item><title>QD Color Tunable Laser (Case 2083)</title><caseId>2083</caseId><link>http://brown.technologypublisher.com/technology/9534</link><description><![CDATA[



Red, Green, and Blue Lasing

&nbsp;
Overview
The semiconductor-based lasers that are commonplace today are powered by a mature technology that allows lasers to be compact and affordable. However, they are not able to cover the full spectrum of visible light. Colloidal quantum dots (CQDs) offer a new way forward. They can create efficient photoluminescence across a wide spectrum of light thanks to quantum effects. Arto Nurmikko has shown how to use films of CQDs to create a CQD-VCSEL laser, which represents a major step toward full-color, single-material lasers.
&nbsp;
Market Opportunity
Qu...]]></description><pubDate>Mon, 11 Jun 2012 10:55:37 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/9534</guid></item><item><title>Improved and Versatile Magnetic Field Sensor: A Magneto-Optoelectronic Device (Case 1424)</title><caseId>1424</caseId><link>http://brown.technologypublisher.com/technology/9527</link><description><![CDATA[Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;The ability to remotely sense magnetic fields without direct physical presence or contact with the field location is important in many industrial/commercial and military applications from environmental monitoring/testing to microelectronics manufacturing.&nbsp; Measurements of magnetic field changes are often needed in a difficult, hostile or otherwise inaccessible environment, as in earthquake warnings, battlefield sensing, in the sensing of information in a mag...]]></description><pubDate>Mon, 11 Jun 2012 10:55:32 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/9527</guid></item><item><title>Micronized Hydrophobic Agents/Drugs for Superior Performance  Medical and Otherwise  (Case 1429)</title><caseId>1429</caseId><link>http://brown.technologypublisher.com/technology/9525</link><description><![CDATA[Novel Technique for IV Injection of Hydrophobic Drugs &nbsp;

&nbsp;
Overview
Intravenous delivery is the quickest, most reliable means of distributing drugs throughout the body. Injected materials, however, are normally cleared over the course of mere hours via organs such as the liver, spleen, and kidney and, more generally, by the mononuclear phagocytic system. Our novel technique for IV injection of hydrophobic drugs is based on the idea that hydrogel microparticles can be injected safely, and will persist longest in circulation, when their size and stiffness closely align with those of wh...]]></description><pubDate>Mon, 11 Jun 2012 10:55:30 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/9525</guid></item><item><title>Interactive, Multilayer, Multivalued Volume-Rendering for Superior 3D Images from MRI or Other Data (Case 1492)</title><caseId>1492</caseId><link>http://brown.technologypublisher.com/technology/9523</link><description><![CDATA[Principal Investigator:&nbsp;David Laidlaw, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Magnetic resonance imaging (MRI) is a well-established and powerful technique for elucidating structure and is used, for example, in medical applications to discriminate between normal and pathological tissue.&nbsp; The MRI image contrast and clarity depends on several technical and complex parameters including data capture, quality and processing, and media, among others.&nbsp; MR images (MRIs), as well as other imaging modalities (PET, CT, EEG, e...]]></description><pubDate>Mon, 11 Jun 2012 10:55:29 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/9523</guid></item><item><title>Improved, Scalable, Optical Particle/Molecule Detector System by Solid State Energy Sources (Case 1494)</title><caseId>1494</caseId><link>http://brown.technologypublisher.com/technology/9522</link><description><![CDATA[Principal Investigator:&nbsp;Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;With environmental safety and defense/bioterrorism concerns, and the continuing drive for important medical breakthroughs, quick and accurate particle diagnostic capabilities have become increasingly important to identify and quantify biological/environmental contaminants and to assay biological substances such as anthrax spores in air or reticulocytes in blood.&nbsp; Numerous and varied particle detection approaches exist, but require precise alignment of ...]]></description><pubDate>Mon, 11 Jun 2012 10:55:28 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/9522</guid></item><item><title>Novel, Versatile System for Progenitor Cell Recruitment in Tissue Repair/Regeneration (Case 1594)</title><caseId>1594</caseId><link>http://brown.technologypublisher.com/technology/9517</link><description><![CDATA[Principal Investigator: &nbsp;Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology &amp; Biotechnology&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;Brown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Within the last decade, there is growing significant data on the therapeutic potential of endothelial progenitor cells (EPCs).&nbsp; EPCs present in bone marrow can be recruited in vivo in adult animals and humans for direct, effective targeted in situ treatment, and/or harvested for autologous re-implantation or transplantation anew in another patient.&nbs...]]></description><pubDate>Mon, 11 Jun 2012 10:55:24 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/9517</guid></item><item><title>Nanostructured sorbent materials for capturing environmental mercury vapor (Case 1887)</title><caseId>1887</caseId><link>http://brown.technologypublisher.com/technology/9094</link><description>Overview
Mercury is a toxic pollutant that can persist in the environment and build up in the food chain. While regulations and new innovations have curtailed the use of mercury in many household items such as thermometers, it remains in use in ubiquitous products such as compact fluorescent lamp (CFL) light bulbs. Hurt et. al. have developed a solution that uses nanomaterials to absorb mercury vapor, which could have widespread applications in curtailing the damage caused by this material.

Market Opportunity
Around 300 million CFLs are sold in the United States each year, in large part becau...</description><pubDate>Fri, 09 Mar 2012 15:35:53 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/9094</guid></item><item><title>Efficient, Dynamic Method to Prove Data Integrity in Remote Servers/Clouds (Case 1927)</title><caseId>1927</caseId><link>http://brown.technologypublisher.com/technology/8471</link><description><![CDATA[Principal Investigator:&nbsp;&nbsp; &nbsp;Roberto Tamassia, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Increasingly, companies and individuals require and/or prefer online data storage-outsourcing services, outsourced database services, peer-to-peer (P2P) storage, and network file systems. Data/files are stored at third party, untrusted remote servers for subsequent access, downloading and uploading from often multiple locations by several users. &nbsp;In these common scenarios, it is important to verify if one&rsquo;s data has been ...]]></description><pubDate>Wed, 07 Dec 2011 11:39:52 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/8471</guid></item><item><title>Secure and Authenticated Data Storage, Access and Retrieval - Optimized (Case 1928)</title><caseId>1928</caseId><link>http://brown.technologypublisher.com/technology/8470</link><description><![CDATA[Secure and Authenticated Data Storage, Access, and Retrieval

&nbsp;
Overview
Cloud storage of information continues to grow in popularity as a way for both corporations and consumers to store large amounts of data. Online storage allows files to be stored on remote or geographically dispersed servers, which not only protects the information in case of disaster or physical damage to an office or home but also allows people who are physically separated to access files.&nbsp;

To trust their cloud storage service, however, a person or business must be able to verify the security of their remotel...]]></description><pubDate>Wed, 07 Dec 2011 11:39:51 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/8470</guid></item><item><title>Advanced, Sensitive, Broad Tractography Metrics to Characterize Cerebral White Matter (Case 1732)</title><caseId>1732</caseId><link>http://brown.technologypublisher.com/technology/8441</link><description><![CDATA[Principal Investigator:&nbsp; David Laidlaw, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that measures the directionally dependent rate of water self-diffusion in each image voxel or volumetric picture element - a 3-dimensional pixel.&nbsp; Water diffusion in cerebral white matter tends to be anisotropic due to the highly linear organization of white matter fibers.&nbsp; Anisotropic refers to the preferential rapid diffuse along white matter tracts as a re...]]></description><pubDate>Tue, 06 Dec 2011 07:16:52 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/8441</guid></item><item><title>Advanced, Flexible and Versatile, 3D Electromagnetic Tracking and Positioning System (Case 1780)</title><caseId>1780</caseId><link>http://brown.technologypublisher.com/technology/8440</link><description><![CDATA[Principal Investigator:&nbsp;Harvey Silverman, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;A typical system for determining the position and orientation of a remote object includes, most simply, a receiver with three receiver coils and a transmitter with three transmitter coils in various orientations to one another to generate electromagnetic fields defining a reference coordinate system.&nbsp; Voltages are induced, measured and summed; the measured values of the induced voltages are used to indicate position and orientation of the remote obj...]]></description><pubDate>Tue, 06 Dec 2011 07:16:51 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/8440</guid></item><item><title>Fast, Improved Data Authentication and Security in Electronic Record Transfers (Case 1781)</title><caseId>1781</caseId><link>http://brown.technologypublisher.com/technology/8439</link><description><![CDATA[Principal Investigator:&nbsp; Roberto Tamassia, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Verifying authenticity of stored content is a fundamental problem in peer-to-peer (p2p) networks.&nbsp; There is a continual need and desire for increased security to protect electronic data in many forms, as applications and networks grow in scale and complexity.&nbsp; Peer-to-peer networks share and disperse data originating from a trusted source over remote, untrusted network nodes, and this data is queried and retrieved by end-users through...]]></description><pubDate>Tue, 06 Dec 2011 07:16:50 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/8439</guid></item><item><title>Novel Microchannel Arrangement for Better Microfluidic Fuel Cell Performance</title><caseId>1870</caseId><link>http://brown.technologypublisher.com/technology/8438</link><description><![CDATA[
Overview

In many conventional reactive microfluidic channels, (e.g., fuel cells), the reaction rate declines along the length of the microfluidic channel. In fuel cells, this can lead to declines in current and power density. We have invented a geometric arrangement for channels through which liquids or other fluids flow, for enhanced performance of fuel cells and other chemical or biochemical reactors and analyzers.

&nbsp;

Market Opportunity

&nbsp;

Microfluidic fuel cells consist of an anode and cathode configured as a galvanic cell in a microchannel. Parallel streams of fuel and oxidan...]]></description><pubDate>Tue, 06 Dec 2011 07:16:49 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/8438</guid></item><item><title>Innovative and Versatile Nanoparticles/Spheres for Robust Oral Drug Delivery (Case 2029)</title><caseId>2029</caseId><link>http://brown.technologypublisher.com/technology/7961</link><description><![CDATA[Principal Investigator:&nbsp;Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology &amp; BiotechnologyBrown UniversityProvidence, RI&nbsp;Brief Description: &nbsp;The use of micro- and nanoparticles for drug delivery is well known. &nbsp;Specifically, microsphere- and nanosphere-based polymeric drug delivery systems have great potential as oral delivery systems due to their ability to protect encapsulated active agents from the harsh gastrointestinal tract.&nbsp; Although significant effort has focused on developing effective delivery systems for clinical use...]]></description><pubDate>Tue, 11 Oct 2011 12:20:31 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/7961</guid></item><item><title>Metabolomics – A New Method for the Chemical Derivatization of Low Molecular Weight Metabolites – Indicators of Disease (Case 2103)</title><caseId>2103</caseId><link>http://brown.technologypublisher.com/technology/7954</link><description><![CDATA[Principal Investigator:&nbsp; Jason Sello, PhD,&nbsp; Associate Professor Department of ChemistryBrown UniversityProvidence, RI&nbsp;Brief Description:&nbsp;Current metabolomics analyses require the simultaneous identification and/or characterization of hundreds to thousands of metabolites in complex samples as indicators of disease.&nbsp; Isolation and detection techniques are required, and a common strategy is to chemically derivatize metabolites to impart physiochemical properties in order to simplify and facilitate analysis.&nbsp; However, structural diversity of metabolites in these compl...]]></description><pubDate>Fri, 07 Oct 2011 11:27:11 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/7954</guid></item><item><title>Innovative Drug Delivery Systems (Case 2023)</title><caseId>2023</caseId><link>http://brown.technologypublisher.com/technology/5887</link><description><![CDATA[Innovative Drug Delivery Systems

Overview
We have developed two novel drug delivery systems that &nbsp;improve upon current bolus delivery strategies. The first prepares and uses a multi-layer polymeric microstructure &ldquo;smart&rdquo; delivery system for controlled release of therapeutics. The second is a magnetic drug delivery device for localized treatment of internal diseases and disorders.

Market Opportunity
There is an urgent need for microencapsulation and phase-separation techniques that slow the release of therapeutics from wet-spun microfiber-based drug delivery systems, to preve...]]></description><pubDate>Thu, 21 Oct 2010 09:29:05 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/5887</guid></item><item><title>Improved Compound for Treatment of Diuresis (Case 2022)</title><caseId>2022</caseId><link>http://brown.technologypublisher.com/technology/5750</link><description><![CDATA[Principal Investigator:&nbsp;Edith Mathiowitz, PhD, ProfessorDepartment of Bio&nbsp;Med Molecular Pharmacology, Physiology &amp; BiotechnologyBrown University&nbsp;Providence, RI&nbsp;Brief Description:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Currently, more than 5.8 million Americans are affected by congestive heart failure (CHF). &nbsp;Furosemide, a loop diuretic widely prescribed to CHF patients, rids the body of excess water, reduces blood pressure and mobilizes edemas. &nbsp;However, due to the narrow window of furosemide absorption, occurring in the proximal gast...]]></description><pubDate>Fri, 01 Oct 2010 12:56:10 GMT</pubDate><author>jennifer_l_vieira@brown.edu</author><guid>http://brown.technologypublisher.com/technology/5750</guid></item></channel></rss>