Search Results - drug+delivery

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Dual stimuli-responsive silver loaded nanoparticles eliminate bacterial biofilms

Dual stimuli-responsive silver loaded nanoparticles eliminate bacterial biofilms Overview Bacterial biofilms are complex, 3D bacterial communities that are embedded in a self-produced matrix of extracellular polymeric substances. Although biofilms are a common occurrence in human infections, they are extremely difficult to eradicate as their matrix...

Published: 11/25/2024 | Inventor(s): Anita Shukla, Yingying Wang, Zhaowei Jiang

Keywords(s):

Category(s): Nanotechnology, Infectious Disease, Drug Delivery

Parenteral and oral delivery of antibodies

Overview With their high molecular weight and susceptibility to degradation by both enzymes and extreme pH values, proteins such as antibodies usually display poor absorption across epithelial membranes and low oral bioavailability. We have invented pharmaceutical compositions that contain micronized antibodies encapsulated and/or dispersed in polymeric...

Published: 2/22/2024 | Inventor(s): Edith Mathiowitz, Aharon Azagury, Stacia Furtado, Yumiko Mizuno

Keywords(s):

Category(s): Drug Delivery

Composition for Increased Systemic Uptake of Nanoparticles Following Oral or Mucosal Drug Delivery

Overview The use of oral drug delivery systems based on polymeric particles has been historically limited by stomach acidity, enzymatic activity, and low penetration through the GI tissue. We have invented pharmaceutical formulations containing coated particles that have increased systemic uptake into the blood and/or increased local GI uptake. The...

Published: 6/7/2023 | Inventor(s): Edith Mathiowitz, Aharon Azagury, Kosta Milovanovic, Cameron Baptista, Carder Jones

Keywords(s):

Category(s): Drug Delivery

A Novel Liposomal Formulation to Target Candida

Overview The yeast Candida lives on the skin and in many places inside the human body, often without causing any health problems. However, it can cause infections, especially if it reaches the bloodstream. Shukla and colleagues have developed a liposomal formulation containing a novel targeting peptide for delivering antifungal treatments inside the...

Published: 6/4/2023 | Inventor(s): Anita Shukla, Noel Vera-Gonzalez, Sarah Cowles, Christina Bailey-Hytholt, Eli Silvert

Keywords(s):

Category(s): Drug Delivery

Aspartic Protease-Triggered Antifungal Hydrogels

Overview Antimicrobial-resistant Candida is a growing public health problem. We have developed an aspartic protease-triggered hydrogel system that selectively delivers an antifungal drug only in the presence of a virulent, pathogenic Candida fungal infection. Market Opportunity Candida is the most common cause of fungal infections, and antimicrobial-resistant...

Published: 4/27/2023 | Inventor(s): Anita Shukla, Noel Vera-Gonzalez

Keywords(s):

Category(s): Drug Delivery

Novel Chromogenic Beta-Lactamase Substrate for Diagnostic Biomaterials

Overview Chromogenic beta-lactamase substrates are used to diagnose bacterial infections. Yet those currently available lose their diagnostic color-change capability when chemically modified. We have synthesized a novel chromogenic beta-lactam molecule (“ANT”) that retains its color-change response when modified for conjugation to a range...

Published: 11/21/2022 | Inventor(s): Anita Shukla, Dahlia Alkekhia, Shashank Shukla, Hannah Safford

Keywords(s):

Category(s): Diagnostics, Drug Delivery

Responsive Hydrogel Systems to Regulate pH of Breast Cancer Tumor Microenvironment

Overview The acidification of cancer microenvironments is a well-known characteristic of solid tumors. Our novel hydrogel systems restore pH homeostasis by reducing pH levels within the tumor, thereby limiting drug resistance and metastasis. Market Opportunity Solid tumors grow faster than the blood supply to them, causing formation of a microenvironment...

Published: 11/1/2022 | Inventor(s): Vikas Srivastava, Savan Santoki, Sijun Niu

Keywords(s):

Category(s): Drug Delivery

Hyper-compliant polymer particles

Overview Polymer microbeads have been used extensively for biomedical applications, including device calibration, drug delivery, tissue engineering, and encapsulation of therapeutic agents. But their effectiveness is limited by the lack of microbeads that are similar to living cells. Our novel method is the first to produce polymer microbeads with...

Published: 11/1/2022 | Inventor(s): Eric Darling, Edith Mathiowitz, Nicholas Labriola

Keywords(s):

Category(s): Drug Delivery, Research Tools

Antibacterial and Antibiofilm Polyurethane Coating for Intravascular Catheters

Overview Catheter-related bloodstream infections (CRBSIs) are a leading cause of hospital-acquired infections worldwide. Our auranofin-releasing antibacterial and antibiofilm polyurethane catheter coating kills bacteria and prevents them from forming hard-to-eliminate biofilms. Market Opportunity Intravascular catheters are used for hemodynamic monitoring,...

Published: 11/1/2022 | Inventor(s): Anita Shukla, Beth Fuchs, Eleftherios Mylonakis, Hanyang Liu

Keywords(s):

Category(s): Drug Delivery, Devices

𝜷‐Lactamase-Responsive Degradable Hydrogels

Overview Antibiotic-resistance poses a serious public health problem. We have developed a hydrogel (hydrated polymer network) that is sensitive to β-lactamases, a class of enzymes released by a variety of harmful bacteria. In the presence of β-lactamases, the hydrogel degrades, releasing the therapeutic agent it contains. Market Opportunity The...

Published: 10/17/2022 | Inventor(s): Anita Shukla, Dahlia Alkekhia, Chao Yu

Keywords(s):

Category(s): Drug Delivery

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