Search Results - drug+delivery

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Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acids into Cells (Case 2055)
Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acid into Cells Overview The use of small interfering RNA (siRNA), which silences gene expression, holds great clinical promise for the treatment of a variety of diseases. Researchers have been exploring the clinical potential of siRNAs for over two decades, and the first siRNA-based therapeutic,...
Published: 7/27/2021   |   Inventor(s): Thomas Webster, Qian Chen, Yupeng Chen, Yingjie Guan
Category(s): Drug Delivery, Nanotechnology, Research Tools, Therapeutics, Diagnostics
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release Overview Effective “smart” fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure “smart” delivery system for...
Published: 7/14/2020   |   Inventor(s): Edith Mathiowitz, Richard Hopkins, Danya Lavin (formerly Decoteau)
Category(s): Drug Delivery, Stem Cells and Regenerative Medicine, Therapeutics, Devices, Nanotechnology, Research Tools
Optogenetic Control of the Blood Brain Barrier for Drug Delivery (Case 2135)
Optogenetic Control of the Blood Brain Barrier for Drug Delivery Overview The blood–brain barrier (BBB) remains a significant impediment to drug development for central nervous system (CNS) disorders. Our novel method provides a way to regulate the permeability of the BBB, enabling delivery of therapeutics to the brain with high spatial and temporal...
Published: 4/28/2020   |   Inventor(s): Christopher Moore, Tyler Brown
Category(s): Engineering and Sensors, Drug Delivery, Neuroscience, Oncology, Therapeutics
New Composition for Biologics (Case 2289)
Principal Investigator(s):Edith Mathiowitz, Ph.D.Professor of Medical Science and EngineeringDirector of the Graduate Program in BiotechnologyBrown UniversityProvidence, RIBrief Description:The market for protein/peptide-based therapeutics has become decidedly established in the past decade, although the gastrointestinal tract causes a significant drug-delivery...
Published: 4/14/2020   |   Inventor(s): Edith Mathiowitz, Nejat Egilmez, Stacia Furtado, Thomas Conway
Category(s): Drug Delivery
Optimized, Cost Effective X-Ray Imaging that Rivals MRI: X-Ray Spatial Frequency Heterodyne Imaging with Protein-Based “Nanobubble” Contrast Agents
Principal Investigator: Christoph Rose-Petruck, PhD, ProfessorDepartment of ChemistryBrown UniversityProvidence, RIBrief Description:Spatial Frequency Heterodyne Imaging (SFHI) is a novel x-ray scatter imaging technique that utilizes nanoparticle contrast agents. Previous studies on SFHI have utilized only metal nanoparticle contrast agents such as...
Published: 4/8/2020   |   Inventor(s): Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
Category(s): Diagnostics, Drug Delivery, Instruments, Nanotechnology, Oncology, Research Tools
Tunable Antimicrobial-Loaded Gellan Hydrogels for Burn Wound Dressings/Infections (Case 2327)
Principal Investigator(s):Anita ShuklaAssistant Professor of EngineeringAssistant Professor of Molecular Pharmacology, Physiology and BiotechnologyBrown UniversityProvidence, RIBrief Description:Bacterial infection is a very common complication in all classes of wounds. Although all wounds are at risk of infection, burns seem to carry a particular risk...
Published: 2/10/2017   |   Inventor(s): Anita Shukla, Shashank Shukla
Category(s): Drug Delivery
New and Improved Antibacterial Compounds (Case 2062)
Principal Investigator:Jason Sello, PhD, Assistant ProfessorDepartment of Chemistry Brown UniversityProvidence, RIBrief Description: Infectious diseases are the second leading cause of death – globally. Antibiotic drug resistance is a major clinical and societal problem, with many...
Published: 8/19/2015   |   Inventor(s): Jason Sello
Category(s): Drug Delivery, Metabolic diseases, Oncology
Screening Method for Inhibitors of Multidrug-Resistance Transporters (Case 2079)
Novel Screening Method for Inhibitors of Multidrug-Resistant Transporters Overview Drug transport is of fundamental importance to the efficacy and toxicity of all drugs. From the route of administration to the site of action, a drug encounters numerous biological barriers, including efflux pumps that pump drugs out of cells. Our novel method uses...
Published: 8/16/2012   |   Inventor(s): Jeffrey Morgan, Anubhav Tripathi, Toni-Marie Achilli (formerly Ferrucc, Stephanie Mccalla
Category(s): Drug Delivery, Oncology, Research Tools, Diagnostics, Metabolic diseases
Advanced, Wireless, Implantable Neural Recording and Stimulation Microsystem (Case 2032)
Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With the advent of advanced materials, MEMs, microfluidics, nanotechnology and interdisciplinary research programs between engineering fields and the biomedical sciences, miniaturized, next generation devices are now being developed...
Published: 6/20/2012   |   Inventor(s): Arto Nurmikko, Ming Yin, William Patterson Iii, Juan Aceros, David Borton, Christopher Bull, Farah Laiwalla
Category(s): Devices, Diagnostics, Drug Delivery, Engineering and Sensors, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Stem Cells and Regenerative Medicine
Micronized Hydrophobic Agents/Drugs for Superior Performance Medical and Otherwise (Case 1429)
Novel Technique for IV Injection of Hydrophobic Drugs Overview Intravenous delivery is the quickest, most reliable means of distributing drugs throughout the body. Injected materials, however, are normally cleared over the course of mere hours via organs such as the liver, spleen, and kidney and, more generally, by the mononuclear phagocytic system....
Published: 6/11/2012   |   Inventor(s): Edith Mathiowitz
Category(s): Therapeutics, Drug Delivery, Environmental, Nanotechnology
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