Search Results - metabolic+diseases

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Metabolite Treatments for Metabolic Dysfunction and Neurological Disease Caused by Mutations in Mitochondrial Enzyme GPT2

Overview The mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2) is necessary for metabolic mechanisms central to neuronal survival and axonal growth. Having demonstrated that loss-of-function mutations in GPT2 cause neuronal vulnerabilities involved in a variety of brain diseases and areas of brain function, we have developed a metabolite...

Published: 10/12/2022 | Inventor(s): Eric Morrow

Keywords(s):

Category(s): Metabolic diseases, Therapy Targets

METHODS AND COMPOSITIONS FOR TREATING OBESITY BY OPSIN 3 REGULATION OF HYPOTHALAMIC MELANOCORTIN RECEPTORS

Preventing and Treating Obesity through Opsin 3 Regulation of Hypothalamic Melanocortin Receptors Overview Obesity is a worldwide health problem. The complex disease disrupts many body systems and reduces life expectancy. Our technology offers a safe, effective way to prevent and treat obesity and obesity-related disorders through opsin 3 regulation...

Published: 2/22/2022 | Inventor(s): Elena Oancea

Keywords(s):

Category(s): Therapeutics, Metabolic diseases

Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)

Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...

Published: 4/28/2020 | Inventor(s): John Savage, Eric Rachlin, Andre Dehon, Charles Lieber

Keywords(s):

Category(s): Devices, Diagnostics, Engineering and Sensors, Environmental, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine

New and Improved Antibacterial Compounds (Case 2062)

Principal Investigator:Jason Sello, PhD, Assistant ProfessorDepartment of Chemistry Brown UniversityProvidence, RIBrief Description: Infectious diseases are the second leading cause of death – globally. Antibiotic drug resistance is a major clinical and societal problem, with many...

Published: 8/19/2015 | Inventor(s): Jason Sello

Keywords(s):

Category(s): Drug Delivery, Metabolic diseases, Oncology

Screening Method for Inhibitors of Multidrug-Resistance Transporters (Case 2079)

Novel Screening Method for Inhibitors of Multidrug-Resistant Transporters Overview Drug transport is of fundamental importance to the efficacy and toxicity of all drugs. From the route of administration to the site of action, a drug encounters numerous biological barriers, including efflux pumps that pump drugs out of cells. Our novel method uses...

Published: 8/16/2012 | Inventor(s): Jeffrey Morgan, Anubhav Tripathi, Toni-Marie Achilli (formerly Ferrucc, Stephanie Mccalla

Keywords(s):

Category(s): Drug Delivery, Oncology, Research Tools, Diagnostics, Metabolic diseases

Advanced, Wireless, Implantable Neural Recording and Stimulation Microsystem (Case 2032)

Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With the advent of advanced materials, MEMs, microfluidics, nanotechnology and interdisciplinary research programs between engineering fields and the biomedical sciences, miniaturized, next generation devices are now being developed...

Published: 6/20/2012 | Inventor(s): Arto Nurmikko, Ming Yin, William Patterson Iii, Juan Aceros, David Borton, Christopher Bull, Farah Laiwalla

Keywords(s):

Category(s): Devices, Diagnostics, Drug Delivery, Engineering and Sensors, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Stem Cells and Regenerative Medicine

Interactive, Multilayer, Multivalued Volume-Rendering for Superior 3D Images from MRI or Other Data (Case 1492)

Principal Investigator:David Laidlaw, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RIBrief Description:Magnetic resonance imaging (MRI) is a well-established and powerful technique for elucidating structure and is used, for example, in medical applications to discriminate between normal and pathological tissue. The MRI image...

Published: 6/11/2012 | Inventor(s): David Laidlaw, Andreas Wenger

Keywords(s):

Category(s): Devices, Diagnostics, Engineering and Sensors, Instruments, Metabolic diseases, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine

Improved, Scalable, Optical Particle/Molecule Detector System by Solid State Energy Sources (Case 1494)

Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With environmental safety and defense/bioterrorism concerns, and the continuing drive for important medical breakthroughs, quick and accurate particle diagnostic capabilities have become increasingly important to identify and quantify...

Published: 6/11/2012 | Inventor(s): Arto Nurmikko, Richard Chang

Keywords(s):

Category(s): Devices, Diagnostics, Energy, Engineering and Sensors, Environmental, Instruments, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Stem Cells and Regenerative Medicine

Advanced, Sensitive, Broad Tractography Metrics to Characterize Cerebral White Matter (Case 1732)

Principal Investigator: David Laidlaw, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that measures the directionally dependent rate of water self-diffusion in each image voxel or volumetric picture element - a 3-dimensional...

Published: 12/6/2011 | Inventor(s): David Laidlaw, Song Zhang, Stephanie Lee

Keywords(s):

Category(s): Devices, Diagnostics, Environmental, Instruments, Metabolic diseases, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine

Advanced, Flexible and Versatile, 3D Electromagnetic Tracking and Positioning System (Case 1780)

Principal Investigator:Harvey Silverman, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:A typical system for determining the position and orientation of a remote object includes, most simply, a receiver with three receiver coils and a transmitter with three transmitter coils in various orientations to one another...

Published: 12/6/2011 | Inventor(s): Harvey Silverman, William Patterson Iii

Keywords(s):

Category(s): Devices, Diagnostics, Drug Delivery, Energy, Engineering and Sensors, Environmental, Instruments, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine

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