Search Results - diagnostics

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Treating Glioblastoma, Metastatic Melanoma, and Other Tumors Involving CNS Metastases
Overview Metastasis involving the spread of systemic cancer to the brain typically results in neurologic disability and death; current treatments are largely palliative in nature. We have invented a method of treatment based on determining whether the patient has an increased level of MDM2/MDM4 genes and/or proteins and/or a decreased level of CDKN2A...
Published: 6/7/2023   |   Inventor(s): Wafik El-Deiry, Taylor Arnoff
Keywords(s):  
Category(s): Diagnostics, Therapy Targets, Oncology
Novel Chromogenic Beta-Lactamase Substrate for Diagnostic Biomaterials
Overview Chromogenic beta-lactamase substrates are used to diagnose bacterial infections. Yet those currently available lose their diagnostic color-change capability when chemically modified. We have synthesized a novel chromogenic beta-lactam molecule (“ANT”) that retains its color-change response when modified for conjugation to a range...
Published: 11/21/2022   |   Inventor(s): Anita Shukla, Dahlia Alkekhia, Shashank Shukla, Hannah Safford
Keywords(s):  
Category(s): Diagnostics, Drug Delivery
Low-Noise Amplifier for High-Speed Tunneling-Recognition Diagnostics
Overview Though optical and mechanical nanosensors may operate near their intrinsic noise floors, electronic platforms often plateau at limits determined jointly by the sensors and their electronic acquisition circuits. We have invented a low-noise method for the detection and determination of biomolecules obtained from high-speed electron-tunneling...
Published: 11/1/2022   |   Inventor(s): Jacob Rosenstein
Keywords(s):  
Category(s): Diagnostics, Engineering and Sensors
Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders
­Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders Overview Early diagnosis of Alzheimer’s Disease (AD) and related disorders has historically been hampered by lack of readily accessible biomarkers. We have identified biomarkers present in the saliva that can distinguish between individuals with...
Published: 6/30/2022   |   Inventor(s): Jill Kreiling, Peter Quesenberry, Zhijin Wu
Keywords(s):  
Category(s): Diagnostics, Central Nervous System(CNS)
Plasmonic Interferometry Cytokine Detection
­Plasmonic Interferometry Cytokine Detection Overview Optical interferometry is a valuable tool in fields ranging from fiber optics and biomedical imaging to astronomy. Plasmonics interferometry, which enables the guiding and manipulation of light in devices much smaller than the wavelength of the incident light, makes use of the ability of metal...
Published: 11/1/2021   |   Inventor(s): Tayhas Palmore, Domenico Pacifici, Henri Lezec, Vihang Mehta, Alec Roelke, Vince Siu
Keywords(s):  
Category(s): Diagnostics, Devices
Method to Predict and Diagnose Seizures and Other Neurological Events (Case 2045)
Method to Predict and Diagnose Seizures and Other Neurological Events Overview Though epilepsy is a common neurological disorder, the medical community still struggles to define and understand seizures and related neurological events. Our method uses implanted microelectrode arrays to predict and detect neurological events—a crucial first step...
Published: 2/3/2021   |   Inventor(s): John Donoghue, Leigh Hochberg, Wilson Truccolo
Keywords(s):  
Category(s): Diagnostics, Instruments, Neuroscience, Software
Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)
Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...
Published: 4/28/2020   |   Inventor(s): John Savage, Eric Rachlin, Andre Dehon, Charles Lieber
Keywords(s):  
Category(s): Devices, Diagnostics, Engineering and Sensors, Environmental, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine
Methylation Cytometry Diagnostic for Immuno-Oncology  (Case 2073)
Methylation Cytometry Diagnostic for Immuno-Oncology Overview DNA methylation-based biomarkers have great potential to transform the diagnosis, monitoring, and treatment of cancer and other diseases. DNA methylation is an epigenetic mechanism used by cells to control gene expression. During DNA methylation, methyl groups are added to the DNA molecule,...
Published: 4/8/2020   |   Inventor(s): Karl Kelsey, William Accomando, E. Andrés Houseman, John Wiencke, Carmen Marsit
Keywords(s):  
Category(s): Diagnostics
Optimized, Cost Effective X-Ray Imaging that Rivals MRI: X-Ray Spatial Frequency Heterodyne Imaging with Protein-Based “Nanobubble” Contrast Agents
Principal Investigator: Christoph Rose-Petruck, PhD, ProfessorDepartment of ChemistryBrown UniversityProvidence, RIBrief Description:Spatial Frequency Heterodyne Imaging (SFHI) is a novel x-ray scatter imaging technique that utilizes nanoparticle contrast agents. Previous studies on SFHI have utilized only metal nanoparticle contrast agents such as...
Published: 4/8/2020   |   Inventor(s): Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
Keywords(s):  
Category(s): Diagnostics, Drug Delivery, Instruments, Nanotechnology, Oncology, Research Tools
Fast Detection of Hypervirulent Clostridium Difficile (Case 1952)
Fast Detection of Hypervirulent Clostridium Difficile Overview When a patient presents with symptoms of Clostridium difficile (C. difficile), rapid determination of the toxicity of the strain is of paramount importance; if a hypervirulent strain is identified, it is important to begin appropriate antimicrobial therapy as quickly as possible. Our...
Published: 4/7/2020   |   Inventor(s): Anubhav Tripathi, Leonard Mermel, Aleksey Novikov, Jennifer Fieber, Leah Seward, Aartik Sarma
Keywords(s): Hospital Acquired Diseases, Nosocomial
Category(s): Diagnostics
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