Search Results - diagnostics

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Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders
­Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders Overview Early diagnosis of Alzheimer’s Disease (AD) and related disorders has historically been hampered by lack of readily accessible biomarkers. We have identified biomarkers present in the saliva that can distinguish between individuals with...
Published: 6/30/2022   |   Inventor(s): Jill Kreiling, Peter Quesenberry, Zhijin Wu
Keywords(s):  
Category(s): Diagnostics, Central Nervous System(CNS)
A Massively Parallel RNA virus (e.g. COVID-19) Diagnostic Test
­A Massively Parallel RNA virus (e.g. COVID-19) Diagnostic Test Overview The COVID-19 pandemic has taught us that the ease and capacity of testing is an essential component to reducing both the spread of the infection and burden on the healthcare system. We have devised a simple, high throughput testing apparatus that has the capability for multiplexing...
Published: 2/28/2022   |   Inventor(s): William Fairbrother
Keywords(s):  
Category(s): Diagnostics, Infectious Disease
Plasmonic Interferometry Cytokine Detection
­Plasmonic Interferometry Cytokine Detection Overview Optical interferometry is a valuable tool in fields ranging from fiber optics and biomedical imaging to astronomy. Plasmonics interferometry, which enables the guiding and manipulation of light in devices much smaller than the wavelength of the incident light, makes use of the ability of metal...
Published: 11/1/2021   |   Inventor(s): Domenico Pacifici, Tayhas Palmore, Henri Lezec, Vihang Mehta, Alec Roelke, Vince Siu
Keywords(s):  
Category(s): Diagnostics, Devices
Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acids into Cells (Case 2055)
Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acid into Cells Overview The use of small interfering RNA (siRNA), which silences gene expression, holds great clinical promise for the treatment of a variety of diseases. Researchers have been exploring the clinical potential of siRNAs for over two decades, and the first siRNA-based therapeutic,...
Published: 7/27/2021   |   Inventor(s): Thomas Webster, Qian Chen, Yupeng Chen, Yingjie Guan
Keywords(s):  
Category(s): Drug Delivery, Nanotechnology, Research Tools, Therapeutics, Diagnostics
Method to Predict and Diagnose Seizures and Other Neurological Events (Case 2045)
Method to Predict and Diagnose Seizures and Other Neurological Events Overview Though epilepsy is a common neurological disorder, the medical community still struggles to define and understand seizures and related neurological events. Our method uses implanted microelectrode arrays to predict and detect neurological events—a crucial first step...
Published: 2/3/2021   |   Inventor(s): John Donoghue, Leigh Hochberg, Wilson Truccolo
Keywords(s):  
Category(s): Diagnostics, Instruments, Neuroscience, Software
Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)
Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...
Published: 4/28/2020   |   Inventor(s): John Savage, Eric Rachlin, Andre Dehon, Charles Lieber
Keywords(s):  
Category(s): Devices, Diagnostics, Engineering and Sensors, Environmental, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine
Methylation Cytometry Diagnostic for Immuno-Oncology  (Case 2073)
Methylation Cytometry Diagnostic for Immuno-Oncology Overview DNA methylation-based biomarkers have great potential to transform the diagnosis, monitoring, and treatment of cancer and other diseases. DNA methylation is an epigenetic mechanism used by cells to control gene expression. During DNA methylation, methyl groups are added to the DNA molecule,...
Published: 4/8/2020   |   Inventor(s): Karl Kelsey, William Accomando, E. Andrés Houseman, John Wiencke, Carmen Marsit
Keywords(s):  
Category(s): Diagnostics
Optimized, Cost Effective X-Ray Imaging that Rivals MRI: X-Ray Spatial Frequency Heterodyne Imaging with Protein-Based “Nanobubble” Contrast Agents
Principal Investigator: Christoph Rose-Petruck, PhD, ProfessorDepartment of ChemistryBrown UniversityProvidence, RIBrief Description:Spatial Frequency Heterodyne Imaging (SFHI) is a novel x-ray scatter imaging technique that utilizes nanoparticle contrast agents. Previous studies on SFHI have utilized only metal nanoparticle contrast agents such as...
Published: 4/8/2020   |   Inventor(s): Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
Keywords(s):  
Category(s): Diagnostics, Drug Delivery, Instruments, Nanotechnology, Oncology, Research Tools
Fast Detection of Hypervirulent Clostridium Difficile (Case 1952)
Fast Detection of Hypervirulent Clostridium Difficile Overview When a patient presents with symptoms of Clostridium difficile (C. difficile), rapid determination of the toxicity of the strain is of paramount importance; if a hypervirulent strain is identified, it is important to begin appropriate antimicrobial therapy as quickly as possible. Our...
Published: 4/7/2020   |   Inventor(s): Anubhav Tripathi, Leonard Mermel, Aleksey Novikov, Jennifer Fieber, Leah Seward, Aartik Sarma
Keywords(s): Hospital Acquired Diseases, Nosocomial
Category(s): Diagnostics
Optimized, Cost Effective X-Ray Imaging that Rivals MRI: X-Ray Scatter Imaging of Nanoparticle-Labeled Tissues for Early Cancer Detection (Case 2093)
Optimized, Cost Effective X-Ray Imaging that Rivals MRI Overview The most common form of liver cancer in adults, hepatocellular carcinoma (HCC) is difficult to detect in its early stages using existing technologies such as computed tomography (CT) or magnetic resonance imaging (MRI). Rose-Petruck’s invention allows for the earlier detection of...
Published: 4/7/2020   |   Inventor(s): Christoph Rose-Petruck, Danielle Rand, Zoltan Derdak, Jack Wands
Keywords(s):  
Category(s): Oncology, Diagnostics, Nanotechnology
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