Search Results - edith+mathiowitz

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Parenteral and oral delivery of antibodies

Overview With their high molecular weight and susceptibility to degradation by both enzymes and extreme pH values, proteins such as antibodies usually display poor absorption across epithelial membranes and low oral bioavailability. We have invented pharmaceutical compositions that contain micronized antibodies encapsulated and/or dispersed in polymeric...

Published: 2/22/2024 | Inventor(s): Edith Mathiowitz, Aharon Azagury, Stacia Furtado, Yumiko Mizuno

Keywords(s):

Category(s): Drug Delivery

Composition for Increased Systemic Uptake of Nanoparticles Following Oral or Mucosal Drug Delivery

Overview The use of oral drug delivery systems based on polymeric particles has been historically limited by stomach acidity, enzymatic activity, and low penetration through the GI tissue. We have invented pharmaceutical formulations containing coated particles that have increased systemic uptake into the blood and/or increased local GI uptake. The...

Published: 6/7/2023 | Inventor(s): Edith Mathiowitz, Aharon Azagury, Kosta Milovanovic, Cameron Baptista, Carder Jones

Keywords(s):

Category(s): Drug Delivery

Hyper-compliant polymer particles

Overview Polymer microbeads have been used extensively for biomedical applications, including device calibration, drug delivery, tissue engineering, and encapsulation of therapeutic agents. But their effectiveness is limited by the lack of microbeads that are similar to living cells. Our novel method is the first to produce polymer microbeads with...

Published: 11/1/2022 | Inventor(s): Eric Darling, Edith Mathiowitz, Nicholas Labriola

Keywords(s):

Category(s): Drug Delivery, Research Tools

Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)

Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release Overview Effective “smart” fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure “smart” delivery system for...

Published: 7/14/2020 | Inventor(s): Edith Mathiowitz, Richard Hopkins, Danya Lavin (formerly Decoteau)

Keywords(s):

Category(s): Drug Delivery, Stem Cells and Regenerative Medicine, Therapeutics, Devices, Nanotechnology, Research Tools

New Composition for Biologics (Case 2289)

Principal Investigator(s):Edith Mathiowitz, Ph.D.Professor of Medical Science and EngineeringDirector of the Graduate Program in BiotechnologyBrown UniversityProvidence, RIBrief Description:The market for protein/peptide-based therapeutics has become decidedly established in the past decade, although the gastrointestinal tract causes a significant drug-delivery...

Published: 4/14/2020 | Inventor(s): Edith Mathiowitz, Nejat Egilmez, Stacia Furtado, Thomas Conway

Keywords(s):

Category(s): Drug Delivery

Micronized Hydrophobic Agents/Drugs for Superior Performance Medical and Otherwise (Case 1429)

Novel Technique for IV Injection of Hydrophobic Drugs Overview Intravenous delivery is the quickest, most reliable means of distributing drugs throughout the body. Injected materials, however, are normally cleared over the course of mere hours via organs such as the liver, spleen, and kidney and, more generally, by the mononuclear phagocytic system....

Published: 6/11/2012 | Inventor(s): Edith Mathiowitz

Keywords(s):

Category(s): Therapeutics, Drug Delivery, Environmental, Nanotechnology

Novel, Versatile System for Progenitor Cell Recruitment in Tissue Repair/Regeneration (Case 1594)

Principal Investigator: Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & Biotechnology Brown UniversityProvidence, RIBrief Description:Within the last decade, there is growing significant data on the therapeutic potential of endothelial progenitor cells (EPCs). EPCs present in bone marrow can be...

Published: 6/11/2012 | Inventor(s): Edith Mathiowitz, Diana James (formerly Ferris)

Keywords(s):

Category(s): Drug Delivery, Nanotechnology, Stem Cells and Regenerative Medicine, Devices, Research Tools, Therapeutics

Innovative and Versatile Nanoparticles/Spheres for Robust Oral Drug Delivery (Case 2029)

Principal Investigator:Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & BiotechnologyBrown UniversityProvidence, RIBrief Description: The use of micro- and nanoparticles for drug delivery is well known. Specifically, microsphere- and nanosphere-based polymeric drug delivery systems have great potential...

Published: 10/11/2011 | Inventor(s): Edith Mathiowitz, Joshua Reineke, Daniel Cho

Keywords(s):

Category(s): Drug Delivery, Nanotechnology, Research Tools, Therapeutics, Devices

Innovative Drug Delivery Systems (Case 2023)

Innovative Drug Delivery Systems Overview We have developed two novel drug delivery systems that improve upon current bolus delivery strategies. The first prepares and uses a multi-layer polymeric microstructure “smart” delivery system for controlled release of therapeutics. The second is a magnetic drug delivery device for localized treatment...

Published: 10/21/2010 | Inventor(s): Edith Mathiowitz, Bryan Laulicht

Keywords(s):

Category(s): Drug Delivery, Devices, Therapeutics

Improved Compound for Treatment of Diuresis (Case 2022)

Principal Investigator:Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & BiotechnologyBrown University Providence, RIBrief Description: Currently, more than 5.8 million Americans are affected by congestive heart failure (CHF). Furosemide, a loop diuretic widely prescribed to CHF patients, rids the...

Published: 10/1/2010 | Inventor(s): Edith Mathiowitz, Bryan Laulicht

Keywords(s):

Category(s): Metabolic diseases, Therapeutics, Drug Delivery