Search Results - therapeutics

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Robust, Stable and ‘Smart’ Microstructure Drug Delivery for Controlled Release (Case 2035)
Principal Investigator: Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & Biotechnology Brown UniversityProvidence, RIBrief Description: Advances in polymer and drug delivery sciences have led to the evolution of engineered fibers for use as drug delivery...
Published: 7/14/2020   |   Inventor(s): Edith Mathiowitz, Richard Hopkins, Danya Lavin (formerly Decoteau)
Keywords(s):  
Category(s): Drug Delivery, Stem Cells and Regenerative Medicine, Therapeutics, Devices, Nanotechnology, Research Tools
Novel Therapeutic For Treating Brain Injury (Case 2118)
Principal Investigator:John Marshall, Ph.D.Professor of Medical ScienceBrown UniversityProvidence, RIBrief Description:The technology is a novel therapeutic for treating brain injuries, particularly those resulting from stroke, traumatic brain injury (TBI), and spinal cord injury (SCI). The technology has been tested in cell culture and rats, and preliminary...
Published: 4/28/2020   |   Inventor(s): John Marshall, Dennis Goebel, Maik Huttemann
Keywords(s):  
Category(s): Therapeutics
Optogenetic Control of the Blood Brain Barrier for Drug Delivery (Case 2135)
Principle Investigator:Christopher Moore, PhD, Associate Professor Department of NeuroscienceBrown UniversityBrief Description:The blood-brain-barrier (BBB) blocks approximately 98% of small molecule therapeutics and almost 100% of large molecular therapeutics from reaching the central nervous system, creating a challenge in drug delivery for treatment...
Published: 4/28/2020   |   Inventor(s): Christopher Moore, Tyler Brown
Keywords(s):  
Category(s): Engineering and Sensors, Drug Delivery, Neuroscience, Oncology, Therapeutics
Minimally-Invasive and Activity Dependent Control of Excitable Neurons (Case 2333)
Principal Investigator:Christopher Moore, PhD, Associate ProfessorDepartment of NeuroscienceBrown UniversityProvidence, RIBrief Description:Abnormal cellular bursting is involved in a number of disease states. These include Parkinson’s Disease, affecting 1 million Americans and incurring an annual cost of $25 billion, and epilepsy, affecting 2...
Published: 3/30/2020   |   Inventor(s): Christopher Moore, Ute Hochgeschwender
Keywords(s):  
Category(s): Neuroscience, Therapeutics
Compounds for the Treatment and Prevention of Infections(EA) (Case 2165)
Principal Investigator:Walter Atwood, PhD, ProfessorDepartment of Bio Med Molecular & Cellular Biology BiochemistryBrown UniversityProvidence, RI Brief Description:Common Polyomaviruses can be severe and debilitating in immunocompromised patients with advanced age, HIV or an organ transplant are particularly susceptible. No effective vaccines or...
Published: 12/8/2014   |   Inventor(s): Walter Atwood, Jason Sello, Christian Nelson, Daniel Carney
Keywords(s):  
Category(s): Therapeutics, Immunology and Vaccines
Micronized Hydrophobic Agents/Drugs for Superior Performance Medical and Otherwise (Case 1429)
Principal Investigator:Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & BiotechnologyBrown UniversityProvidence, RIBrief Description:Many hydrophobic agents, active and non-active, have utility in a variety of in vivo settings – medical and otherwise. Although techniques exist for preparing and formulating...
Published: 6/11/2012   |   Inventor(s): Edith Mathiowitz
Keywords(s):  
Category(s): Therapeutics, Drug Delivery, Environmental, Nanotechnology
Novel, Versatile System for Progenitor Cell Recruitment in Tissue Repair/Regeneration (Case 1594)
Principal Investigator: Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & Biotechnology Brown UniversityProvidence, RIBrief Description:Within the last decade, there is growing significant data on the therapeutic potential of endothelial progenitor cells (EPCs). EPCs present in bone marrow can be...
Published: 6/11/2012   |   Inventor(s): Edith Mathiowitz, Diana James (formerly Ferris)
Keywords(s):  
Category(s): Drug Delivery, Nanotechnology, Stem Cells and Regenerative Medicine, Devices, Research Tools, Therapeutics
Innovative and Versatile Nanoparticles/Spheres for Robust Oral Drug Delivery (Case 2029)
Principal Investigator:Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & BiotechnologyBrown UniversityProvidence, RIBrief Description: The use of micro- and nanoparticles for drug delivery is well known. Specifically, microsphere- and nanosphere-based polymeric drug delivery systems have great potential...
Published: 10/11/2011   |   Inventor(s): Edith Mathiowitz, Joshua Reineke, Daniel Cho
Keywords(s):  
Category(s): Drug Delivery, Nanotechnology, Research Tools, Therapeutics, Devices
Innovative Real-Time Magnetic Targeting in the Gastrointestinal Tract for Enhanced Drug Delivery (Case 2023)
Principal Investigator:Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & BiotechnologyBrown UniversityProvidence, RIBrief Description: For many orally administered pharmaceuticals, increased residence time in a particular region of the gastrointestinal (GI) tract would greatly improve their therapeutic benefit....
Published: 10/21/2010   |   Inventor(s): Edith Mathiowitz, Bryan Laulicht
Keywords(s):  
Category(s): Drug Delivery, Devices, Therapeutics
Improved Compound for Treatment of Diuresis (Case 2022)
Principal Investigator:Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & BiotechnologyBrown University Providence, RIBrief Description: Currently, more than 5.8 million Americans are affected by congestive heart failure (CHF). Furosemide, a loop diuretic widely prescribed to CHF patients, rids the...
Published: 10/1/2010   |   Inventor(s): Edith Mathiowitz, Bryan Laulicht
Keywords(s):  
Category(s): Metabolic diseases, Therapeutics, Drug Delivery
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