Search Results - therapeutics

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New use of CsA-type drugs for the prevention and treatment of neurodegenerative disorders, including Alzheimer’s disease
­Novel Method Repurposes CsA-Type Compounds to Treat Neurodegenerative Disease Overview Alzheimer’s disease remains a challenging disorder for drug development, with many candidate drugs failing clinical trials. Our novel method repurposes camphorsulfonic acid (CsA)-type compounds to treat early-stage Alzheimer’s disease, as well as...
Published: 4/29/2022   |   Inventor(s): Robbert Creton
Category(s): Therapeutics, Neurodegenerative Disease
Small molecule CB002 and its analogs restore the p53 pathway and target an S-phase checkpoint
­Novel Class of Small Molecules Restores Important p53 Pathway Overview Approximately 50% of human cancers involve mutations in the tumor-suppressor gene p53, while the other 50% involve some type of inactivation on the p53 pathway. We have discovered a class of small molecules that restore the p53 pathway, as well as perturb an S-phase checkpoint. ...
Published: 2/22/2022   |   Inventor(s): Wafik El-Deiry, Liz Borrero
Category(s): Therapeutics, Oncology
Targeting enhancer RNAs (eRNA) for the treatment of primary brain tumors
­Novel Therapeutic Approach for Glioblastoma Overview Enhancer RNAs (eRNAs) are transcribed from active enhancer regions of the genome and function to increase the expression of target genes. The expression of specific eRNAs in glioma stem cells is correlated with decreased survival of patients with glioblastomas. Our novel technology uses synthetic...
Published: 2/22/2022   |   Inventor(s): Nikolaos (Nikos) Tapinos, Blessing Akobundu
Category(s): Therapeutics, Oncology
­Preventing and Treating Obesity through Opsin 3 Regulation of Hypothalamic Melanocortin Receptors Overview Obesity is a worldwide health problem. The complex disease disrupts many body systems and reduces life expectancy. Our technology offers a safe, effective way to prevent and treat obesity and obesity-related disorders through opsin 3 regulation...
Published: 2/22/2022   |   Inventor(s): Elena Oancea
Category(s): Therapeutics, Metabolic diseases
Inhibition of Glycogen Synthase Kinase 3-beta (GSK3-b) with the small molecule 9-ING-41 stimulates Natural Killer and T cell activity, reduces vascular endothelial growth factor levels, and induces cancer cell death.
­Overview In recent years, immune checkpoint blockade (ICB) has provided oncologists with a powerful new tool. But while ICB has been found to be effective in microsatellite instability-high (MSI-H) colorectal cancer, it is far less effective in microsatellite stable (MSS) colorectal cancer. We have developed glycogen synthase kinase-beta (GSK-3-b)...
Published: 2/8/2022   |   Inventor(s): Wafik El-Deiry, Kelsey Huntington, Benedito Carneiro
Category(s): Therapeutics, Oncology
Novel Antibacterial Compounds Avoid Microbial Resistance
Novel Antibacterial Compounds Avoid Microbial Resistance Overview According to the Centers for Disease Control’s Antibiotic Resistance Threats in the United States, 2019, more than 2.8 million antibiotic-resistant infections occur in the United States each year, and more than 35,000 people die as a result. Thus there is an urgent need for new...
Published: 9/7/2021   |   Inventor(s): Amit Basu, Christopher Reid
Category(s): Therapeutics
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases (Case 1939)
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases Overview Stroke and other neurological insults entail a build-up of waste materials in brain cells. One of the most common waste materials is glutamate, which is present in more than 50 percent of nervous tissue. Glutamate receptors are critical to neuronal functioning. Failure...
Published: 8/11/2021   |   Inventor(s): John Marshall, Mark Spaller, Dennis Goebel
Category(s): Neuroscience, Research Tools, Therapeutics
Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acids into Cells (Case 2055)
Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acid into Cells Overview The use of small interfering RNA (siRNA), which silences gene expression, holds great clinical promise for the treatment of a variety of diseases. Researchers have been exploring the clinical potential of siRNAs for over two decades, and the first siRNA-based therapeutic,...
Published: 7/27/2021   |   Inventor(s): Thomas Webster, Qian Chen, Yupeng Chen, Yingjie Guan
Category(s): Drug Delivery, Nanotechnology, Research Tools, Therapeutics, Diagnostics
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release Overview Effective “smart” fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure “smart” delivery system for...
Published: 7/14/2020   |   Inventor(s): Edith Mathiowitz, Richard Hopkins, Danya Lavin (formerly Decoteau)
Category(s): Drug Delivery, Stem Cells and Regenerative Medicine, Therapeutics, Devices, Nanotechnology, Research Tools
Novel Therapeutic For Treating Brain Injury (Case 2118)
Novel Therapeutic for Treating Brain Injury Overview Our invention uses a compound that mimics a natural peptide or protein, called a peptidomimetic compound, to treat neuronal injury. Administered prophylactically as soon as possible after injury, the compound is particularly effective in the case of stroke, traumatic brain injury (TBI), and spinal...
Published: 4/28/2020   |   Inventor(s): John Marshall, Dennis Goebel, Maik Huttemann
Category(s): Therapeutics
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