Search Results - christopher+moore

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Dopamine (DA) control of blood-brain barrier (BBB) permeability

Transient blood-brain barrier opening via brain subsystem stimulation Overview One of the primary obstacles of delivering pharmacological agents to the brain is the blood-brain barrier (BBB). This technology describes methods for selectively opening the BBB by stimulating dopaminergic neurons in specific areas of the midbrain, particularly the ventral...

Published: 5/22/2025 | Inventor(s): Christopher Moore, Sinda Fekir

Keywords(s):

Category(s): Neuroscience, Neurotechnology, Central Nervous System(CNS), Drug Delivery

Optogenetic Control of the Blood Brain Barrier for Drug Delivery (Case 2135)

Optogenetic Control of the Blood Brain Barrier for Drug Delivery Overview The blood–brain barrier (BBB) remains a significant impediment to drug development for central nervous system (CNS) disorders. Our novel method provides a way to regulate the permeability of the BBB, enabling delivery of therapeutics to the brain with high spatial and temporal...

Published: 4/28/2020 | Inventor(s): Christopher Moore, Tyler Brown

Keywords(s):

Category(s): Engineering and Sensors, Drug Delivery, Neuroscience, Oncology, Therapeutics

Minimally-Invasive and Activity Dependent Control of Excitable Neurons (Case 2333)

Minimally Invasive Optogenetic Control of Excitable Neurons Overview Optogenetics uses light to modulate excitable cells containing light-sensitive ion channels, known as opsins When activated by light, opsins cause depolarization or hyperpolarization of cell membranes, resulting in cellular excitation or silencing on a short time scale. Our minimally...

Published: 3/30/2020 | Inventor(s): Christopher Moore, Ute Hochgeschwender

Keywords(s):

Category(s): Neuroscience, Therapeutics