Search Results - christopher+moore

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Optogenetic Control of the Blood Brain Barrier for Drug Delivery (Case 2135)

Optogenetic Control of the Blood Brain Barrier for Drug Delivery Overview The blood–brain barrier (BBB) remains a significant impediment to drug development for central nervous system (CNS) disorders. Our novel method provides a way to regulate the permeability of the BBB, enabling delivery of therapeutics to the brain with high spatial and temporal...

Published: 4/28/2020 | Inventor(s): Christopher Moore, Tyler Brown

Keywords(s):

Category(s): Engineering and Sensors, Drug Delivery, Neuroscience, Oncology, Therapeutics

Minimally-Invasive and Activity Dependent Control of Excitable Neurons (Case 2333)

Minimally Invasive Optogenetic Control of Excitable Neurons Overview Optogenetics uses light to modulate excitable cells containing light-sensitive ion channels, known as opsins When activated by light, opsins cause depolarization or hyperpolarization of cell membranes, resulting in cellular excitation or silencing on a short time scale. Our minimally...

Published: 3/30/2020 | Inventor(s): Christopher Moore, Ute Hochgeschwender

Keywords(s):

Category(s): Neuroscience, Therapeutics