Search Results - anita+shukla

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A Novel Liposomal Formulation to Target Candida

Overview The yeast Candida lives on the skin and in many places inside the human body, often without causing any health problems. However, it can cause infections, especially if it reaches the bloodstream. Shukla and colleagues have developed a liposomal formulation containing a novel targeting peptide for delivering antifungal treatments inside the...

Published: 6/4/2023 | Inventor(s): Anita Shukla, Noel Vera-Gonzalez, Sarah Cowles, Christina Bailey-Hytholt, Eli Silvert

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Category(s): Drug Delivery

Aspartic Protease-Triggered Antifungal Hydrogels

Overview Antimicrobial-resistant Candida is a growing public health problem. We have developed an aspartic protease-triggered hydrogel system that selectively delivers an antifungal drug only in the presence of a virulent, pathogenic Candida fungal infection. Market Opportunity Candida is the most common cause of fungal infections, and antimicrobial-resistant...

Published: 4/27/2023 | Inventor(s): Anita Shukla, Noel Vera-Gonzalez

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Category(s): Drug Delivery

Novel Chromogenic Beta-Lactamase Substrate for Diagnostic Biomaterials

Overview Chromogenic beta-lactamase substrates are used to diagnose bacterial infections. Yet those currently available lose their diagnostic color-change capability when chemically modified. We have synthesized a novel chromogenic beta-lactam molecule (“ANT”) that retains its color-change response when modified for conjugation to a range...

Published: 11/21/2022 | Inventor(s): Anita Shukla, Dahlia Alkekhia, Shashank Shukla, Hannah Safford

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Category(s): Diagnostics, Drug Delivery

Antibacterial and Antibiofilm Polyurethane Coating for Intravascular Catheters

Overview Catheter-related bloodstream infections (CRBSIs) are a leading cause of hospital-acquired infections worldwide. Our auranofin-releasing antibacterial and antibiofilm polyurethane catheter coating kills bacteria and prevents them from forming hard-to-eliminate biofilms. Market Opportunity Intravascular catheters are used for hemodynamic monitoring,...

Published: 11/1/2022 | Inventor(s): Anita Shukla, Beth Fuchs, Eleftherios Mylonakis, Hanyang Liu

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Category(s): Drug Delivery, Devices

𝜷‐Lactamase-Responsive Degradable Hydrogels

Overview Antibiotic-resistance poses a serious public health problem. We have developed a hydrogel (hydrated polymer network) that is sensitive to β-lactamases, a class of enzymes released by a variety of harmful bacteria. In the presence of β-lactamases, the hydrogel degrades, releasing the therapeutic agent it contains. Market Opportunity The...

Published: 10/17/2022 | Inventor(s): Anita Shukla, Dahlia Alkekhia, Chao Yu

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Category(s): Drug Delivery

Bacteria Responsive Antibiofilm Polymer Nanoparticles

Overview Biofilm infections are common and difficult to treat. Nanoparticles that respond to multiple bacterial stimuli have the potential to successfully prevent and eradicate biofilms. We have developed a hyaluronic acid- and chitosan-coated, antibiotic-loaded gelatin nanoparticle that effectively combats bacterial biofilms. Market Opportunity Bacterial...

Published: 10/17/2022 | Inventor(s): Anita Shukla, Yingying Wang

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Category(s): Drug Delivery

Placental lipid bilayer for cell-free molecular interaction studies

Overview Researchers and clinicians have a need for in vitro or in vivo tools to quantify placental interactions at the molecular scale. Lipid bilayers have been used to model biological interfaces, including those in the liver, red blood cells or myelin. We have developed a lipid bilayer that mimics the lipid composition of the placenta. Market...

Published: 10/17/2022 | Inventor(s): Anita Shukla, Christina Bailey-Hytholt, Anubhav Tripathi

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Category(s): Drug Delivery, Research Tools

Tunable Antimicrobial-Loaded Gellan Hydrogels for Burn Wound Dressings

Overview The standard practice of treating burn wounds preventatively with broad-spectrum antibiotics contributes to the growing problem of antibiotic resistance. Exposure to systemic antibiotics also leads to toxicity in unaffected tissues. Using FDA-approved methods, we have developed a gellan hydrogel delivery system with tunable mechanical and...

Published: 2/10/2017 | Inventor(s): Anita Shukla, Shashank Shukla

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Category(s): Drug Delivery