Search Results - wafik+el-deiry

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Anti-Cancer Maleimide Derivatives for Use with Immune Checkpoint Blockade
Overview We have invented a cancer treatment that consists of administering an anti-cancer maleimide derivative together with an immune checkpoint blockade. Market Opportunity Globally, colorectal cancer (CRC) ranks third in incidence and second in mortality. The U.S. Food and Drug Administration recently approved the checkpoint inhibitors nivolumab...
Published: 6/7/2023   |   Inventor(s): Wafik El-Deiry, Kelsey Huntington
Category(s): Therapeutics, Oncology
Covid Prevention and Treatment Using an Integrin Inhibitor
Overview Although several highly effective vaccines against COVID-19 have been developed, the disease remains a threat to public health. We have invented a method of preventing or treating COVID-19 through administration of an integrin inhibitor such as GLPG-0187. Market Opportunity Although several highly effective vaccines against COVID-19 have...
Published: 6/7/2023   |   Inventor(s): Wafik El-Deiry, Kelsey Huntington, Lindsey Carlsen, Olin Liang, Matthias Piesche
Category(s): Therapeutics, Infectious Disease
Treating Glioblastoma, Metastatic Melanoma, and Other Tumors Involving CNS Metastases
Overview Metastasis involving the spread of systemic cancer to the brain typically results in neurologic disability and death; current treatments are largely palliative in nature. We have invented a method of treatment based on determining whether the patient has an increased level of MDM2/MDM4 genes and/or proteins and/or a decreased level of CDKN2A...
Published: 6/7/2023   |   Inventor(s): Wafik El-Deiry, Taylor Arnoff
Category(s): Diagnostics, Therapy Targets, Oncology
Identification of Smurf2 as an HIF-1α–Degrading E3 Ubiquitin Ligase
Overview In cancer, hypoxia-inducible factor-1 (HIF-1) signaling promotes vascularization, increasing oxygen supply and facilitating the survival of malignant cells. It is also involved in metabolism alteration, immune evasion, cell invasion, and metastasis. We have determined that SMAD-specific E3 ubiquitin protein ligase 2 (Smurf2) reduces the stability...
Published: 11/1/2022   |   Inventor(s): Wafik El-Deiry, Shuai Zhao
Category(s): Therapy Targets
Small molecule CB002 and its analogs restore the p53 pathway and target an S-phase checkpoint
­Novel Class of Small Molecules Restores Important p53 Pathway Overview Approximately 50% of human cancers involve mutations in the tumor-suppressor gene p53, while the other 50% involve some type of inactivation on the p53 pathway. We have discovered a class of small molecules that restore the p53 pathway, as well as perturb an S-phase checkpoint. ...
Published: 2/22/2022   |   Inventor(s): Wafik El-Deiry, Liz Borrero
Category(s): Therapeutics, Oncology
Inhibition of Glycogen Synthase Kinase 3-beta (GSK3-b) with the small molecule 9-ING-41 stimulates Natural Killer and T cell activity, reduces vascular endothelial growth factor levels, and induces cancer cell death.
­Overview In recent years, immune checkpoint blockade (ICB) has provided oncologists with a powerful new tool. But while ICB has been found to be effective in microsatellite instability-high (MSI-H) colorectal cancer, it is far less effective in microsatellite stable (MSS) colorectal cancer. We have developed glycogen synthase kinase-beta (GSK-3-b)...
Published: 2/8/2022   |   Inventor(s): Wafik El-Deiry, Kelsey Huntington, Benedito Carneiro
Category(s): Therapeutics, Oncology
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