Search Results - Diagnostics

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Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acids into Cells (Case 2055)
Overview The use of small interfering RNA (siRNA), which silences gene expression, holds great clinical promise for the treatment of a variety of diseases. Researchers have been exploring the clinical potential of siRNAs for over two decades, and the first siRNA-based therapeutic, ONPATTRO (patisiran) developed by Alnylam Pharmaceuticals, was finally...
Published: 7/27/2021   |   Inventor(s): Thomas Webster, Qian Chen, Yupeng Chen, Yingjie Guan
Category(s): Drug Delivery, Nanotechnology, Research Tools, Therapeutics, Diagnostics
Method to Predict and Diagnose Seizures and Other Neurological Events (Case 2045)
Overview Though epilepsy is a common neurological disorder, the medical community still struggles to define and understand seizures and related neurological events. Our method uses implanted microelectrode arrays to predict and detect neurological events—a crucial first step toward being able to prevent and control them. Market Opportunity Because...
Published: 2/3/2021   |   Inventor(s): John Donoghue, Leigh Hochberg, Wilson Truccolo
Category(s): Diagnostics, Instruments, Neuroscience, Software
Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)
Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...
Published: 4/28/2020   |   Inventor(s): John Savage, Eric Rachlin, Andre Dehon, Charles Lieber
Category(s): Devices, Diagnostics, Engineering and Sensors, Environmental, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine
Methylation Cytometry Diagnostic for Immuno-Oncology  (Case 2073)
Overview DNA methylation-based biomarkers have great potential to transform the diagnosis, monitoring, and treatment of cancer and other diseases. DNA methylation is an epigenetic mechanism used by cells to control gene expression. During DNA methylation, methyl groups are added to the DNA molecule, changing the DNA activity but not the sequence. Errors...
Published: 4/8/2020   |   Inventor(s): Karl Kelsey, William Accomando, E. Andrés Houseman, John Wiencke, Carmen Marsit
Category(s): Diagnostics
Optimized, Cost Effective X-Ray Imaging that Rivals MRI: X-Ray Spatial Frequency Heterodyne Imaging with Protein-Based “Nanobubble” Contrast Agents
Principal Investigator: Christoph Rose-Petruck, PhD, ProfessorDepartment of ChemistryBrown UniversityProvidence, RIBrief Description:Spatial Frequency Heterodyne Imaging (SFHI) is a novel x-ray scatter imaging technique that utilizes nanoparticle contrast agents. Previous studies on SFHI have utilized only metal nanoparticle contrast agents such as...
Published: 4/8/2020   |   Inventor(s): Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
Category(s): Diagnostics, Drug Delivery, Instruments, Nanotechnology, Oncology, Research Tools
Fast Detection of Hypervirulent Clostridium Difficile (Case 1952)
Principal Investigators: Anubhav Tripathi, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RILeonard Mermel, DO, ProfessorDepartment of MedicineRhode Island HospitalProvidence, RIBrief Description: This invention, using a single reaction tube, rapidly detects the presence of C.difficile and can identify mutations in the bacterial...
Published: 4/7/2020   |   Inventor(s): Jennifer Fieber, Leonard Mermel, Aleksey Novikov, Leah Seward, Anubhav Tripathi, Aartik Sarma
Keywords(s): Hospital Acquired Diseases, Nosocomial
Category(s): Diagnostics
Optimized, Cost Effective X-Ray Imaging that Rivals MRI: X-Ray Scatter Imaging of Nanoparticle-Labeled Tissues for Early Cancer Detection (Case 2093)
Overview The most common form of liver cancer in adults, hepatocellular carcinoma (HCC) is difficult to detect in its early stages using existing technologies such as computed tomography (CT) or magnetic resonance imaging (MRI). Rose-Petruck’s invention allows for the earlier detection of HCCs and other cancers via a novel use of x-rays. His technology...
Published: 4/7/2020   |   Inventor(s): Christoph Rose-Petruck, Danielle Rand, Zoltan Derdak, Jack Wands
Category(s): Oncology, Diagnostics, Nanotechnology
Intra Cellular Delivery of Small Molecules Using Novel Nanotechnology (Case 2060)
Affiliation: Brown UniversityProvidence, RIBrief Description: Pursuit of improved drug delivery vehicles continues to expand and grow with research focusing on a wide variety of approaches and necessary parameters, e.g., injectables, biocompatibility/degradability/availability, materials - polymers and nanoparticles...
Published: 2/2/2017   |   Inventor(s): Thomas Webster
Category(s): Diagnostics, Drug Delivery, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Stem Cells and Regenerative Medicine
Screening Method for Inhibitors of Multidrug-Resistance Transporters (Case 2079)
Principal Investigator: Jeffrey Morgan, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology and BiotechnologyBrown UniversityProvidence, RIBrief Description:Multidrug-resistance transporters (MDR) are protein pumps that are up regulated in diseased cells such as those in cancer patients. These proteins actively pump out beneficial...
Published: 8/16/2012   |   Inventor(s): Jeffrey Morgan, Anubhav Tripathi, Toni-Marie Achilli (formerly Ferrucc, Stephanie Mccalla
Category(s): Drug Delivery, Oncology, Research Tools, Diagnostics, Metabolic diseases
Advanced, Wireless, Implantable Neural Recording and Stimulation Microsystem (Case 2032)
Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With the advent of advanced materials, MEMs, microfluidics, nanotechnology and interdisciplinary research programs between engineering fields and the biomedical sciences, miniaturized, next generation devices are now being developed...
Published: 6/20/2012   |   Inventor(s): Arto Nurmikko, Ming Yin, William Patterson Iii, Juan Aceros, David Borton, Christopher Bull, Farah Laiwalla
Category(s): Devices, Diagnostics, Drug Delivery, Engineering and Sensors, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Stem Cells and Regenerative Medicine
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