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Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model

Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model Overview The extracellular matrix (ECM) of the body is the network of proteins and other molecules that surrounds cells and tissues. The ECM is directly involved in a variety of essential cellular processes including structural support,...

Published: 11/25/2024 | Inventor(s): Jeffrey Morgan, Benjamin Wilks

Keywords(s):

Category(s): Stem Cells and Regenerative Medicine, Research Tools, Drug Discovery Platform

A novel, modular, apparatus to measure rodent spatial and social cognition without the limitations of currently used apparatuses

Overview The ability to understand, create and maintain social relationships is a fundamental part of life. Emerging research shows there is a critical link between the social networks we create and our spatial cognition. For example, social relationships are often described in terms of space, varying from “close” to “distant.”...

Published: 8/6/2024 | Inventor(s): Taylor Wise, Rebecca Burwell

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Category(s): Research Tools

Compositions and Methods for Selectively Detecting and Purifying Line-1 cDNA Synthesized in Vivo

Overview Many age-related diseases, as well as aging itself, are closely associated with chronic low-level inflammation. We have invented a method for treating, preventing, and/or reversing age-associated inflammation by administering a reverse transcriptase inhibitor (RTI) to patients who have a level of retrotransposable element (RTE)-derived Line-1...

Published: 6/7/2023 | Inventor(s): John Sedivy, Alexandra D'Ordine, Anna Petrashen

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Category(s): Research Tools

Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmogenic Toxicity Responses

Overview To guide the development of atrial-specific drugs and evaluate their safety, there is a need for in vitro models to accurately assess the cardiotoxic effects of novel therapeutics in both atrial and ventricular cell populations, with high throughput. We have developed a robust in vitro 3D atrial tissue platform made from human-induced pluripotent...

Published: 6/4/2023 | Inventor(s): Kareen Coulombe, Bum-Rak Choi, Tae Yun Kim, Mark Daley, Arvin Soepriatna

Keywords(s):

Category(s): Research Tools, Stem Cells and Regenerative Medicine

Automated Behavioral Analysis System

Overview The manual annotation of video data in the life sciences creates a number of problems, including those resulting from inherent biases. We have developed a neural network system to identify and automate the labeling of behavior in videos of animal test subjects. Market Opportunity Many areas of the life sciences demand the manual annotation...

Published: 12/21/2022 | Inventor(s): Thomas Serre, Youssef Barhomi, Kevin Bath, Sven Eberhardt, Zachary Nado

Keywords(s):

Category(s): Object Tracking, Research Tools

Hyper-compliant polymer particles

Overview Polymer microbeads have been used extensively for biomedical applications, including device calibration, drug delivery, tissue engineering, and encapsulation of therapeutic agents. But their effectiveness is limited by the lack of microbeads that are similar to living cells. Our novel method is the first to produce polymer microbeads with...

Published: 11/1/2022 | Inventor(s): Eric Darling, Edith Mathiowitz, Nicholas Labriola

Keywords(s):

Category(s): Drug Delivery, Research Tools

SOCKS (Statistical Outlier Curation Kernel Software): A Modern, Efficient Tool for Outlier Detection and Curation

Overview Real-world signal acquisition through sensors is at the heart of the modern digital world, yet almost every signal acquisition system is contaminated with noise and outliers. Our data “sanitizer” tool provides a way to obtain uncorrupted observations. Market Opportunity It is increasingly evident that clarity of digital information...

Published: 11/1/2022 | Inventor(s): Prasanta Pal, Judson Brewer

Keywords(s):

Category(s): Research Tools, Software

Novel Electrical Device to Dissociate Tissue Sections into Single Cells for Downstream Single-Cell Analysis

Overview Single-cell analysis is an important analytical tool for studying heterogeneous cellular populations, such as cancer tissues, where rare mutations can drive metastasis and treatment response outcome. A major limitation of the clinical translation of single-cell analysis is the difficulty of isolating single cells from complex tissues. Our...

Published: 10/17/2022 | Inventor(s): Anubhav Tripathi, E. Celeste (Cel) Welch

Keywords(s):

Category(s): Instruments, Research Tools

Placental lipid bilayer for cell-free molecular interaction studies

Overview Researchers and clinicians have a need for in vitro or in vivo tools to quantify placental interactions at the molecular scale. Lipid bilayers have been used to model biological interfaces, including those in the liver, red blood cells or myelin. We have developed a lipid bilayer that mimics the lipid composition of the placenta. Market...

Published: 10/17/2022 | Inventor(s): Anita Shukla, Christina Bailey-Hytholt, Anubhav Tripathi

Keywords(s):

Category(s): Drug Delivery, Research Tools

System and Method for Measuring Distribution of Deformation Using Atomic Force (not leading)

Interferometric absolute and real-time surface curvature sensor insensitive to tilt, translation and vibration Overview Kyung-Suk Kim has developed a device to improve modern microscopes by allowing them to measure deformations in a surface at the resolution of mere atoms. The invention can improve the resolution of an atomic micrograph system...

Published: 8/3/2022 | Inventor(s): Kyung-Suk Kim

Keywords(s):

Category(s): Research Tools

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