Search Results - Therapy+Targets

8 Results Sort By:
Treating Glioblastoma, Metastatic Melanoma, and Other Tumors Involving CNS Metastases
Overview Metastasis involving the spread of systemic cancer to the brain typically results in neurologic disability and death; current treatments are largely palliative in nature. We have invented a method of treatment based on determining whether the patient has an increased level of MDM2/MDM4 genes and/or proteins and/or a decreased level of CDKN2A...
Published: 6/7/2023   |   Inventor(s): Wafik El-Deiry, Taylor Arnoff
Category(s): Diagnostics, Therapy Targets, Oncology
Chitinase 3-like-1 (CHI3L1) as Biomarker for Hermansky-Pudlak Pulmonary Fibrosis
Overview Hermansky-Pudlak syndrome (HPS) is a group of autosomal recessive disorders caused by mutations that affect the function of lysosome-related organelles (LROs). All HPS patients have oculocutaneous albinism with visual impairment, and many have blood platelet dysfunction with bleeding disorder. HPS-1 and HPS-4 patients, who have mutations of...
Published: 1/21/2023   |   Inventor(s): Jack Elias, Chun Geun Lee, Yang Zhu
Category(s): Therapy Targets
Identification of Smurf2 as an HIF-1α–Degrading E3 Ubiquitin Ligase
Overview In cancer, hypoxia-inducible factor-1 (HIF-1) signaling promotes vascularization, increasing oxygen supply and facilitating the survival of malignant cells. It is also involved in metabolism alteration, immune evasion, cell invasion, and metastasis. We have determined that SMAD-specific E3 ubiquitin protein ligase 2 (Smurf2) reduces the stability...
Published: 11/1/2022   |   Inventor(s): Wafik El-Deiry, Shuai Zhao
Category(s): Therapy Targets
Potential new targets for ALS
Overview Amyotrophic lateral sclerosis (ALS) is a devastating disease that is progressive, invariably fatal, and untreatable. Our invention features isolated Cyp4gl polypeptides with mutations at various key amino acid positions that suppress the effects and progress of ALS, as well as mutated polynucleotides that encode these polypeptides. Our invention...
Published: 10/19/2022   |   Inventor(s): Robert Reenan, Yiannis Savva, Asli Sahin
Category(s): Therapy Targets, Neurodegenerative Disease
HDAC-7 as novel therapeutic target for human glioblastoma
Overview Glioblastoma is one of the most aggressive and lethal human tumors. We have identified histone deacetylase 7 (HDAC-7) as a potential therapeutic target, a crucial first step toward development of an effective treatment for glioblastoma. Market Opportunity Glioblastoma is the most malignant and aggressive primary brain tumor, with a survival...
Published: 10/15/2022   |   Inventor(s): Nikolaos (Nikos) Tapinos, Ola Hassan, David Karambizi
Category(s): Therapy Targets, Oncology
­​​​​​​​Metabolite Treatments for Metabolic Dysfunction and Neurological Disease Caused by Mutations in Mitochondrial Enzyme GPT2
Overview The mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2) is necessary for metabolic mechanisms central to neuronal survival and axonal growth. Having demonstrated that loss-of-function mutations in GPT2 cause neuronal vulnerabilities involved in a variety of brain diseases and areas of brain function, we have developed a metabolite...
Published: 10/12/2022   |   Inventor(s): Eric Morrow
Category(s): Metabolic diseases, Therapy Targets
Proprietary targeting of Oligonucleotide to vulnerable splicing events to efficiently silence genes
Overview The principle of antisense technology is the sequence-specific binding of an antisense oligonucleotide (ASO) to target mRNA and prevent gene translation. We have found the individual events that are most vulnerable to disruption in cancer cells and developed a method to target these events. We can further restrict the points of vulnerability...
Published: 10/12/2022   |   Inventor(s): William Fairbrother, Jeremiah Buerer, David Glidden
Category(s): Drug Discovery Platform, Therapy Targets
A novel nucleocytoplasmic regulator of autophagy-associated transcription factors stimulates autophagy and prevents the proteostatic decline associated with neurodegeneration
­Activating Autophagy to Prevent Neurodegeneration and Extend Lifespan Overview Decline in proteostasis is a hallmark of age-related neurodegerative disease such as Alzheimer’s Disease. Autophagy is the process by which cells rid themselves of damaged or otherwise unnecessary material, which then moves to the lysosome and degrades. Pharmacologic...
Published: 2/22/2022   |   Inventor(s): Louis Lapierre
Category(s): Therapy Targets, Neurodegenerative Disease
© 2024. All Rights Reserved. Powered by Inteum