Search Results - jack+elias

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A novel approach to the treatment of EGFR mutant non-small cell lung cancer (NSCLC)

Background Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for ~85% of all lung cancer cases. NSCLC is slow growing and often diagnosed at later stages when it has already spread, making treatment difficult. Resistance to therapy is a major challenge in effectively treating patients with NSCLC. 10-30% of...

Published: 3/5/2025 | Inventor(s): Jack Elias, Suchitra Kamle, Chun Geun Lee, Bing Ma

Keywords(s):

Category(s): Oncology

Chitinase 3-like-1 (CHI3L1) as Biomarker for Hermansky-Pudlak Pulmonary Fibrosis

Overview Hermansky-Pudlak syndrome (HPS) is a group of autosomal recessive disorders caused by mutations that affect the function of lysosome-related organelles (LROs). All HPS patients have oculocutaneous albinism with visual impairment, and many have blood platelet dysfunction with bleeding disorder. HPS-1 and HPS-4 patients, who have mutations of...

Published: 1/21/2023 | Inventor(s): Jack Elias, Chun Geun Lee, Yang Zhu

Keywords(s):

Category(s): Therapy Targets