Search Results - shuai+zhao

1 Results

Sort By:

Identification of Smurf2 as an HIF-1α–Degrading E3 Ubiquitin Ligase

Overview In cancer, hypoxia-inducible factor-1 (HIF-1) signaling promotes vascularization, increasing oxygen supply and facilitating the survival of malignant cells. It is also involved in metabolism alteration, immune evasion, cell invasion, and metastasis. We have determined that SMAD-specific E3 ubiquitin protein ligase 2 (Smurf2) reduces the stability...

Published: 11/1/2022 | Inventor(s): Wafik El-Deiry, Shuai Zhao

Keywords(s):

Category(s): Therapy Targets