Search Results - Central+Nervous+System(CNS)

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Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders
­Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders Overview Early diagnosis of Alzheimer’s Disease (AD) and related disorders has historically been hampered by lack of readily accessible biomarkers. We have identified biomarkers present in the saliva that can distinguish between individuals with...
Published: 6/30/2022   |   Inventor(s): Jill Kreiling, Peter Quesenberry, Zhijin Wu
Keywords(s):  
Category(s): Diagnostics, Central Nervous System(CNS)
Combinatorial use of markers to isolate synaptic glia to generate synapses in a dish for high-throughput and high-content drug discovery and testing
­Platform for in vitro Analysis of Synaptic Glia and Neuromuscular Synapses Overview Novel in vitro technology to isolate and analyze the glial cells that form neuromuscular synapses will make it easier to discover and test drugs for conditions that affect peripheral nerves and skeletal muscles, such as amyotrophic lateral sclerosis (ALS), spinal...
Published: 2/28/2022   |   Inventor(s): Gregorio Valdez
Keywords(s):  
Category(s): Central Nervous System(CNS), Research Tools
Development and Use of a High-Throughput Screen to Identify Novel Modulators of the Corticotropin Releasing Factor Binding Protein
­Development of a HT Screen to Identify Novel Modulators of the CRFBP Overview A connection between the corticotropin signaling pathway and alcohol use disorder (AUD) has been shown previously. We developed a high throughput screen to identify small molecule modulators of this pathway as potential therapeutics for AUD. Market Opportunity Currently...
Published: 2/22/2022   |   Inventor(s): Carolina Haass-Koffler
Keywords(s):  
Category(s): Drug Discovery Platform, Central Nervous System(CNS)
Peel-Away Electrode Placement Catheter for Deep Brain Stimulation (DBS)
­Brown’s Laboratory for Neurophysiology and Neuromodulation The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design...
Published: 11/1/2021   |   Inventor(s): Wael Asaad, Shane Lee, Owen Leary, Noah Trac, Zakir Tahiry, Rohan Rastogi
Keywords(s):  
Category(s): Central Nervous System(CNS), Devices, Neuroscience
Continuous motor task for objectively quantifying motor symptoms in movement disorders
­Brown’s Laboratory for Neurophysiology and Neuromodulation The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design...
Published: 11/1/2021   |   Inventor(s): Wael Asaad, Shane Lee, Minkyu Ahn, James Yu, Daniel Amaya, David Liu, Peter Lauro
Keywords(s):  
Category(s): Central Nervous System(CNS), Neuroscience, Devices
Novel Shape-Memory Electrodes for Minimally Invasive Spinal Cord Stimulation and Recording
Novel Shape-Memory Electrodes for Minimally Invasive Spinal Cord Stimulation and Recording Overview Neuromodulation is a rapidly expanding field of clinical neuroscience. Yet the widespread use of neuronal probes for recording and functional stimulation has been slow to develop, in part because of incompatibility problems with existing metallic and...
Published: 9/7/2021   |   Inventor(s): Vikas Srivastava, Albert Edward Telfeian, Shailen Sampath
Keywords(s):  
Category(s): Devices, Central Nervous System(CNS)
Intracranial Fixation Device for Probes and Catheters (Case 2253)
Brown’s Laboratory for Neurophysiology and Neuromodulation The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design improved...
Published: 4/28/2020   |   Inventor(s): Wael Asaad, David Segar
Keywords(s):  
Category(s): Central Nervous System(CNS), Devices, Neuroscience
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