Search Results - Central+Nervous+System(CNS)

10 Results

Sort By:

System for Closed-Loop Deep Brain Stimulation Using Neural and Behavioral Biomarkers of Specific Motor Features

System for Closed-Loop Deep Brain Stimulation Using Neural and Behavioral Biomarkers of Specific Motor Features Overview Parkinson’s Disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these different motor states could enable optimal closed-loop neuromodulation....

Published: 12/20/2024 | Inventor(s): Wael Asaad, Shane Lee, Umer Akbar, Peter Lauro

Keywords(s):

Category(s): Central Nervous System(CNS), Biomarker, Neurodegenerative Disease

Use of CRTH2 Antagonist to Treat Neuromyelitis Optica and Other Autoimmune Disorders of the Central Nervous System

Overview The detrimental effects of neuroinflammation, especially neuromyelitis optica spectrum disorder (NMOSD), on cognitive performance can include severe vision loss, motor deficits, and cognitive decline. We have invented a method that targets the detrimental effects of neuroinflammation on cognitive performance by using a CRTH2 (chemoattractant...

Published: 6/7/2023 | Inventor(s): Yu-Wen Huang, Changyong Tang, Wei Qiu, Yaxiong Cui

Keywords(s):

Category(s): Central Nervous System(CNS), Therapeutics

System for facilitating Speech-Based Communication for Individuals Unable to Speak or Write

Overview Our novel communication system enables patients unable to speak or write to communicate with others in real time, through a motion-controlled wireless device. Market Opportunity The use of non-speech communication is important in certain health care situations when a patient is unable to communicate through speech. Examples are when a patient...

Published: 11/1/2022 | Inventor(s): Leigh Hochberg, Miriam Goldberg

Keywords(s):

Category(s): Central Nervous System(CNS), Neurotechnology

Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders

Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders Overview Early diagnosis of Alzheimer’s Disease (AD) and related disorders has historically been hampered by lack of readily accessible biomarkers. We have identified biomarkers present in the saliva that can distinguish between individuals with...

Published: 6/30/2022 | Inventor(s): Jill Kreiling, Peter Quesenberry, Zhijin Wu

Keywords(s):

Category(s): Diagnostics, Central Nervous System(CNS)

Combinatorial use of markers to isolate synaptic glia to generate synapses in a dish for high-throughput and high-content drug discovery and testing

Platform for in vitro Analysis of Synaptic Glia and Neuromuscular Synapses Overview Novel in vitro technology to isolate and analyze the glial cells that form neuromuscular synapses will make it easier to discover and test drugs for conditions that affect peripheral nerves and skeletal muscles, such as amyotrophic lateral sclerosis (ALS), spinal...

Published: 2/28/2022 | Inventor(s): Gregorio Valdez

Keywords(s):

Category(s): Central Nervous System(CNS), Research Tools

Development and Use of a High-Throughput Screen to Identify Novel Modulators of the Corticotropin Releasing Factor Binding Protein

Development of a HT Screen to Identify Novel Modulators of the CRFBP Overview A connection between the corticotropin signaling pathway and alcohol use disorder (AUD) has been shown previously. We developed a high throughput screen to identify small molecule modulators of this pathway as potential therapeutics for AUD. Market Opportunity Currently...

Published: 2/22/2022 | Inventor(s): Carolina Haass-Koffler

Keywords(s):

Category(s): Drug Discovery Platform, Central Nervous System(CNS)

Peel-Away Electrode Placement Catheter for Deep Brain Stimulation (DBS)

Brown’s Laboratory for Neurophysiology and Neuromodulation The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design...

Published: 11/1/2021 | Inventor(s): Wael Asaad, Shane Lee, Owen Leary, Noah Trac, Zakir Tahiry, Rohan Rastogi

Keywords(s):

Category(s): Central Nervous System(CNS), Devices, Neuroscience

Continuous motor task for objectively quantifying motor symptoms in movement disorders

Published: 11/1/2021 | Inventor(s): Wael Asaad, Shane Lee, Minkyu Ahn, James Yu, Daniel Amaya, David Liu, Peter Lauro

Keywords(s):

Category(s): Central Nervous System(CNS), Neuroscience, Devices

Novel Shape-Memory Electrodes for Minimally Invasive Spinal Cord Stimulation and Recording

Novel Shape-Memory Electrodes for Minimally Invasive Spinal Cord Stimulation and Recording Overview Neuromodulation is a rapidly expanding field of clinical neuroscience. Yet the widespread use of neuronal probes for recording and functional stimulation has been slow to develop, in part because of incompatibility problems with existing metallic and...

Published: 9/7/2021 | Inventor(s): Vikas Srivastava, Albert Edward Telfeian, Shailen Sampath

Keywords(s):

Category(s): Devices, Central Nervous System(CNS)

Intracranial Fixation Device for Probes and Catheters (Case 2253)

Published: 4/28/2020 | Inventor(s): Wael Asaad, David Segar

Keywords(s):

Category(s): Central Nervous System(CNS), Devices, Neuroscience