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Novel Electrical Device to Dissociate Tissue Sections into Single Cells for Downstream Single-Cell Analysis

Overview Single-cell analysis is an important analytical tool for studying heterogeneous cellular populations, such as cancer tissues, where rare mutations can drive metastasis and treatment response outcome. A major limitation of the clinical translation of single-cell analysis is the difficulty of isolating single cells from complex tissues. Our...

Published: 10/17/2022 | Inventor(s): Anubhav Tripathi, E. Celeste (Cel) Welch

Keywords(s):

Category(s): Instruments, Research Tools

HIGH RESOLUTION X-RAY DETECTOR SYSTEM

Overview An x-ray detector is only as good as its image resolution. Our technology, which uses coherent bundles of scintillating fibers, provides a substantial increase in resolution over existing x-ray detector technologies. Market Opportunity The usefulness of x-ray imaging’s many medical applications is limited by the image resolution....

Published: 11/29/2021 | Inventor(s): Angus Kingon, Nicholas Mostovych, Theodore Morse

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Category(s): Engineering and Sensors, Instruments

X-ray Imaging with Micron Resolution

Novel Scintillating Detectors for X-ray Imaging with Micron Resolution Overview An x-ray detector is only as good as its image resolution. Our technology, which uses coherent bundles of scintillating fibers, provides a substantial increase in resolution over existing x-ray detector technologies. Market Opportunity The usefulness of x-ray imaging’s...

Published: 9/7/2021 | Inventor(s): Kenneth Breuer, Avilash Cramer, Christopher Bull, Paul Waltz, Ragiv Gupta, Theodore Morse

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Category(s): Engineering and Sensors, Instruments

Method to Predict and Diagnose Seizures and Other Neurological Events (Case 2045)

Method to Predict and Diagnose Seizures and Other Neurological Events Overview Though epilepsy is a common neurological disorder, the medical community still struggles to define and understand seizures and related neurological events. Our method uses implanted microelectrode arrays to predict and detect neurological events—a crucial first step...

Published: 2/3/2021 | Inventor(s): John Donoghue, Leigh Hochberg, Wilson Truccolo

Keywords(s):

Category(s): Diagnostics, Instruments, Neuroscience, Software

Automated Microfluidic Cryo-TEM Sample Prep for Optimal Visualization (Case 1966)

Automated Microfluidic Blotless Specimen Preparation for Cryo-TEM Overview Transmission electron microscopy (TEM) is an important imaging tool in many physical and biological scientific fields. Because current methods for preparing the thin TEM specimens are specific to the material being analyzed and the information being sought, many different...

Published: 4/28/2020 | Inventor(s): Anubhav Tripathi, Jinkee Lee, Arijit Bose

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Category(s): Devices, Engineering and Sensors, Instruments, Nanotechnology, Research Tools

Optimized, Cost Effective X-Ray Imaging that Rivals MRI: X-Ray Spatial Frequency Heterodyne Imaging with Protein-Based “Nanobubble” Contrast Agents

Principal Investigator: Christoph Rose-Petruck, PhD, ProfessorDepartment of ChemistryBrown UniversityProvidence, RIBrief Description:Spatial Frequency Heterodyne Imaging (SFHI) is a novel x-ray scatter imaging technique that utilizes nanoparticle contrast agents. Previous studies on SFHI have utilized only metal nanoparticle contrast agents such as...

Published: 4/8/2020 | Inventor(s): Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida

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Category(s): Diagnostics, Drug Delivery, Instruments, Nanotechnology, Oncology, Research Tools

Supergratings - Improved Detection and Processing of Optical Signals (Case 1466)

Principal Investigator:Jingming Xu, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:Gratings are optical devices used to achieve wavelength-dependent characteristics by means of optical interference effects. These wavelength-dependent optical characteristics can serve to reflect light of a specific wavelength while...

Published: 2/6/2015 | Inventor(s): Daniel Levner, Martin Fay, Jingming Xu

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Category(s): Devices, Engineering and Sensors, Instruments, Research Tools

Improved and Versatile Magnetic Field Sensor: A Magneto-Optoelectronic Device (Case 1424)

Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:The ability to remotely sense magnetic fields without direct physical presence or contact with the field location is important in many industrial/commercial and military applications from environmental monitoring/testing to microelectronics...

Published: 6/11/2012 | Inventor(s): Arto Nurmikko

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Category(s): Devices, Energy, Engineering and Sensors, Environmental, Instruments, Research Tools

Interactive, Multilayer, Multivalued Volume-Rendering for Superior 3D Images from MRI or Other Data (Case 1492)

Principal Investigator:David Laidlaw, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RIBrief Description:Magnetic resonance imaging (MRI) is a well-established and powerful technique for elucidating structure and is used, for example, in medical applications to discriminate between normal and pathological tissue. The MRI image...

Published: 6/11/2012 | Inventor(s): David Laidlaw, Andreas Wenger

Keywords(s):

Category(s): Devices, Diagnostics, Engineering and Sensors, Instruments, Metabolic diseases, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine

Improved, Scalable, Optical Particle/Molecule Detector System by Solid State Energy Sources (Case 1494)

Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With environmental safety and defense/bioterrorism concerns, and the continuing drive for important medical breakthroughs, quick and accurate particle diagnostic capabilities have become increasingly important to identify and quantify...

Published: 6/11/2012 | Inventor(s): Arto Nurmikko, Richard Chang

Keywords(s):

Category(s): Devices, Diagnostics, Energy, Engineering and Sensors, Environmental, Instruments, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Stem Cells and Regenerative Medicine

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