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Small molecule CB002 and its analogs restore the p53 pathway and target an S-phase checkpoint

Novel Class of Small Molecules Restores Important p53 Pathway Overview Approximately 50% of human cancers involve mutations in the tumor-suppressor gene p53, while the other 50% involve some type of inactivation on the p53 pathway. We have discovered a class of small molecules that restore the p53 pathway, as well as perturb an S-phase checkpoint. ...

Published: 2/22/2022 | Inventor(s): Wafik El-Deiry, Liz Borrero

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Category(s): Therapeutics, Oncology