Search Results - kelsey+huntington

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Anti-Cancer Maleimide Derivatives for Use with Immune Checkpoint Blockade

Overview We have invented a cancer treatment that consists of administering an anti-cancer maleimide derivative together with an immune checkpoint blockade. Market Opportunity Globally, colorectal cancer (CRC) ranks third in incidence and second in mortality. The U.S. Food and Drug Administration recently approved the checkpoint inhibitors nivolumab...

Published: 6/7/2023 | Inventor(s): Wafik El-Deiry, Kelsey Huntington

Keywords(s):

Category(s): Therapeutics, Oncology

Covid Prevention and Treatment Using an Integrin Inhibitor

Overview Although several highly effective vaccines against COVID-19 have been developed, the disease remains a threat to public health. We have invented a method of preventing or treating COVID-19 through administration of an integrin inhibitor such as GLPG-0187. Market Opportunity Although several highly effective vaccines against COVID-19 have...

Published: 6/7/2023 | Inventor(s): Wafik El-Deiry, Kelsey Huntington, Lindsey Carlsen, Olin Liang, Matthias Piesche

Keywords(s):

Category(s): Therapeutics, Infectious Disease

Inhibition of Glycogen Synthase Kinase 3-beta (GSK3-b) with the small molecule 9-ING-41 stimulates Natural Killer and T cell activity, reduces vascular endothelial growth factor levels, and induces cancer cell death.

Overview In recent years, immune checkpoint blockade (ICB) has provided oncologists with a powerful new tool. But while ICB has been found to be effective in microsatellite instability-high (MSI-H) colorectal cancer, it is far less effective in microsatellite stable (MSS) colorectal cancer. We have developed glycogen synthase kinase-beta (GSK-3-b)...

Published: 2/8/2022 | Inventor(s): Wafik El-Deiry, Kelsey Huntington, Benedito Carneiro

Keywords(s):

Category(s): Therapeutics, Oncology