Search Results - Neuroscience

18 Results

Sort By:

Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference

Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference Overview Biophysically detailed neural models are powerful tools for bridging scales in neuroscience, linking cellular and circuit-level mechanisms to macro-scale signals like EEG/MEG. These models incorporate ion channels,...

Published: 5/28/2025 | Inventor(s): Stephanie Jones, Nicholas Tolley

Keywords(s):

Category(s): Neuroscience

Process and method for novel biomarker discovery using electromagnetic beta signal waveforms for prediction and diagnosis of neurological disorders and brain states

Dissecting beta waveforms using convolutional dictionary learning across sensory perception, aging, and disease OVERVIEW This technology is a system and method for analyzing brain wave patterns, specifically beta waves (13-30 Hz), to identify biomarkers that can predict neurological conditions and brain states. The technology leverages advanced signal...

Published: 5/22/2025 | Inventor(s): Stephanie Jones, David Zhou

Keywords(s):

Category(s): Aging, Neurodegenerative Disease, Neuroscience

Dopamine (DA) control of blood-brain barrier (BBB) permeability

Transient blood-brain barrier opening via brain subsystem stimulation Overview One of the primary obstacles of delivering pharmacological agents to the brain is the blood-brain barrier (BBB). This technology describes methods for selectively opening the BBB by stimulating dopaminergic neurons in specific areas of the midbrain, particularly the ventral...

Published: 5/22/2025 | Inventor(s): Christopher Moore, Sinda Fekir

Keywords(s):

Category(s): Neuroscience, Neurotechnology, Central Nervous System(CNS), Drug Delivery

SUBCUTANEOUS MULTICHANNEL WIRELESS EEG FOR CHRONIC HOME USE

Subcutaneous Multi-Channel Wireless EEG For Continuous Home Monitoring Overview It is increasingly recognized that for many patients, like those with epilepsy, it can be of paramount importance to record neural activity continuously, 24/7, over weeks and months. Yet, no clinically viable system exists. Currently, the principal diagnostic method for...

Published: 12/20/2024 | Inventor(s): Arto Nurmikko, Farah Laiwalla, Jihun Lee, Ah-Hyoung Lee, Sydney Cash

Keywords(s):

Category(s): Devices, Neurotechnology, Neuroscience

Peel-Away Electrode Placement Catheter for Deep Brain Stimulation (DBS)

Brown’s Laboratory for Neurophysiology and Neuromodulation The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design...

Published: 11/1/2021 | Inventor(s): Wael Asaad, Shane Lee, Owen Leary, Noah Trac, Zakir Tahiry, Rohan Rastogi

Keywords(s):

Category(s): Central Nervous System(CNS), Devices, Neuroscience

Continuous motor task for objectively quantifying motor symptoms in movement disorders

Published: 11/1/2021 | Inventor(s): Wael Asaad, Shane Lee, Minkyu Ahn, James Yu, Daniel Amaya, David Liu, Peter Lauro

Keywords(s):

Category(s): Central Nervous System(CNS), Neuroscience, Devices

Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases (Case 1939)

Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases Overview Stroke and other neurological insults entail a build-up of waste materials in brain cells. One of the most common waste materials is glutamate, which is present in more than 50 percent of nervous tissue. Glutamate receptors are critical to neuronal functioning. Failure...

Published: 8/11/2021 | Inventor(s): John Marshall, Mark Spaller, Dennis Goebel

Keywords(s):

Category(s): Neuroscience, Research Tools, Therapeutics

Method to Predict and Diagnose Seizures and Other Neurological Events (Case 2045)

Method to Predict and Diagnose Seizures and Other Neurological Events Overview Though epilepsy is a common neurological disorder, the medical community still struggles to define and understand seizures and related neurological events. Our method uses implanted microelectrode arrays to predict and detect neurological events—a crucial first step...

Published: 2/3/2021 | Inventor(s): John Donoghue, Leigh Hochberg, Wilson Truccolo

Keywords(s):

Category(s): Diagnostics, Instruments, Neuroscience, Software

Optogenetic Control of the Blood Brain Barrier for Drug Delivery (Case 2135)

Optogenetic Control of the Blood Brain Barrier for Drug Delivery Overview The blood–brain barrier (BBB) remains a significant impediment to drug development for central nervous system (CNS) disorders. Our novel method provides a way to regulate the permeability of the BBB, enabling delivery of therapeutics to the brain with high spatial and temporal...

Published: 4/28/2020 | Inventor(s): Christopher Moore, Tyler Brown

Keywords(s):

Category(s): Engineering and Sensors, Drug Delivery, Neuroscience, Oncology, Therapeutics

Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)

Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...

Published: 4/28/2020 | Inventor(s): John Savage, Eric Rachlin, Andre Dehon, Charles Lieber

Keywords(s):

Category(s): Devices, Diagnostics, Engineering and Sensors, Environmental, Metabolic diseases, Nanotechnology, Neuroscience, Oncology, Research Tools, Software, Stem Cells and Regenerative Medicine

1 2