Search Results - Therapeutics

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Antisense oligonucleotides for rescuing splicing mutations in hotspot exons

An antisense oligonucleotide to rescue multiple splicing mutations in hotspot exons Overview Research by William Fairbrother at Brown University centers around a therapeutic use of ASOs to enhance splicing for various mutations using a single ASO. This can allow for the expansion of treatment options for a broader range of patients with the same underlying...

Published: 10/23/2025 | Inventor(s): William Fairbrother, Jeremiah Buerer, Chaorui Duan

Keywords(s):

Category(s): Assay, Therapeutics

A novel method to achieve polymeric nanoparticles loaded with peptide therapeutics, which display high encapsulation efficiency, low burst release, and long acting sustained release profiles

A novel method to achieve polymeric nanoparticles loaded with peptide therapeutics, which display high encapsulation efficiency, low burst release, and long acting sustained release profiles. Overview A major challenge in the field of peptide and protein therapeutics is effective administration and subsequent delivery to the site of action. Due to...

Published: 8/13/2025 | Inventor(s): Edith Mathiowitz, Cameron Baptista

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Category(s): Therapeutics

A novel molecular target for the treatment of heart failure with preserved ejection fraction

Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy Overview Cardiac hypertrophy, a key risk factor for heart failure and sudden cardiac death, arises from hemodynamic and neurohormonal stress, often culminating in adverse remodeling. While much of the focus has been on activators of hypertrophic signaling, this technology identifies...

Published: 8/13/2025 | Inventor(s): Mukesh Jain, Xudong Liao, Tapatee Das, Yosuke Nagai

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Category(s): Therapeutics

First in class use of the estrogen receptor-b agonist in treating Angelman syndrome and relevant autism spectrum disorders

Overview Angelman syndrome is a genetic disorder caused by UBE3A gene dysfunction, leading to cognitive impairment, motor coordination issues, and developmental delays. Research suggests that oligodendroglial dysfunction, which affects myelination in the brain, contributes to these conditions. Based on the research, this invention discloses a novel...

Published: 3/6/2025 | Inventor(s): Yu-Wen Huang, Xin Yang

Keywords(s):

Category(s): Genetic Diseases, Therapeutics, Therapy Targets

Combining recombinant protein and fibrin spray to increase wound healing

Overview A little-appreciated complication of pneumonia in surgical patients is decreased wound healing. We have invented a treatment method that uses fibrin spray as a vehicle to topically deliver one or more chemokines to accelerate wound healing. Advantages of our method include effectiveness, ease of application, and the use of already-approved...

Published: 2/22/2024 | Inventor(s): Amanda Jamieson, Meredith Crane, Yun Xu

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Category(s): Therapeutics

Small-Molecule Inhibitors of the L-1 Endonuclease Domain

Overview Chronic inflammation is a hallmark of a number of age-related diseases, as well as of aging itself. Nuclear element-1 (L1) plays a key role in this inflammatory process. We have developed the first inhibitors of the L-1 endonuclease (EN) domain and the first of any retrotransposon-encoded EN. Our technology sheds light on the regulators that...

Published: 7/25/2023 | Inventor(s): John Sedivy, Gerwald Jogl, Alexandra D'Ordine

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Category(s): Therapeutics

Anti-Cancer Maleimide Derivatives for Use with Immune Checkpoint Blockade

Overview We have invented a cancer treatment that consists of administering an anti-cancer maleimide derivative together with an immune checkpoint blockade. Market Opportunity Globally, colorectal cancer (CRC) ranks third in incidence and second in mortality. The U.S. Food and Drug Administration recently approved the checkpoint inhibitors nivolumab...

Published: 6/7/2023 | Inventor(s): Wafik El-Deiry, Kelsey Huntington

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Category(s): Therapeutics, Oncology

Use of CRTH2 Antagonist to Treat Neuromyelitis Optica and Other Autoimmune Disorders of the Central Nervous System

Overview The detrimental effects of neuroinflammation, especially neuromyelitis optica spectrum disorder (NMOSD), on cognitive performance can include severe vision loss, motor deficits, and cognitive decline. We have invented a method that targets the detrimental effects of neuroinflammation on cognitive performance by using a CRTH2 (chemoattractant...

Published: 6/7/2023 | Inventor(s): Yu-Wen Huang, Changyong Tang, Wei Qiu, Yaxiong Cui

Keywords(s):

Category(s): Central Nervous System(CNS), Therapeutics

Covid Prevention and Treatment Using an Integrin Inhibitor

Overview Although several highly effective vaccines against COVID-19 have been developed, the disease remains a threat to public health. We have invented a method of preventing or treating COVID-19 through administration of an integrin inhibitor such as GLPG-0187. Market Opportunity Although several highly effective vaccines against COVID-19 have...

Published: 6/7/2023 | Inventor(s): Wafik El-Deiry, Kelsey Huntington, Lindsey Carlsen, Olin Liang, Matthias Piesche

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Category(s): Therapeutics, Infectious Disease

L1 Inhibitor to Prevent Age-Associated Inflammation and Disease

Overview One hallmark of aging is the accumulation of senescent cells that contribute to sterile inflammation, which underlies many age-associated diseases such as osteoarthritis, cancer, and neurodegeneration. Nuclear element-1 (L1), which represents approximately 17% of the human genome, plays a key role in this process. We are identifying candidates...

Published: 1/21/2023 | Inventor(s): John Sedivy, Gerwald Jogl, Alexandra D'Ordine

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Category(s): Therapeutics

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