Search Results - Therapeutics

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Novel Antibacterial Compounds Avoid Microbial Resistance
Overview According to the Centers for Disease Control’s Antibiotic Resistance Threats in the United States, 2019, more than 2.8 million antibiotic-resistant infections occur in the United States each year, and more than 35,000 people die as a result. Thus there is an urgent need for new ant-bacterial compounds that meet minimal or no resistance...
Published: 9/7/2021   |   Inventor(s): Amit Basu, Christopher Reid
Category(s): Therapeutics
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases (Case 1939)
Overview Stroke and other neurological insults entail a build-up of waste materials in brain cells. One of the most common waste materials is glutamate, which is present in more than 50 percent of nervous tissue. Glutamate receptors are critical to neuronal functioning. Failure to regulate these receptors contributes to various neurological disorders...
Published: 8/11/2021   |   Inventor(s): John Marshall, Mark Spaller, Dennis Goebel
Category(s): Neuroscience, Research Tools, Therapeutics
Versatile, Robust Nanotube Delivery of siRNA and Nucleic Acids into Cells (Case 2055)
Overview The use of small interfering RNA (siRNA), which silences gene expression, holds great clinical promise for the treatment of a variety of diseases. Researchers have been exploring the clinical potential of siRNAs for over two decades, and the first siRNA-based therapeutic, ONPATTRO (patisiran) developed by Alnylam Pharmaceuticals, was finally...
Published: 7/27/2021   |   Inventor(s): Thomas Webster, Qian Chen, Yupeng Chen, Yingjie Guan
Category(s): Drug Delivery, Nanotechnology, Research Tools, Therapeutics, Diagnostics
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)
Overview Effective “smart” fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure “smart” delivery system for controlled release of therapeutics. Market Opportunity Drug-eluting fibers can be woven into...
Published: 7/14/2020   |   Inventor(s): Edith Mathiowitz, Richard Hopkins, Danya Lavin (formerly Decoteau)
Category(s): Drug Delivery, Stem Cells and Regenerative Medicine, Therapeutics, Devices, Nanotechnology, Research Tools
Novel Therapeutic For Treating Brain Injury (Case 2118)
Overview Our invention uses a compound that mimics a natural peptide or protein, called a peptidomimetic compound, to treat neuronal injury. Administered prophylactically as soon as possible after injury, the compound is particularly effective in the case of stroke, traumatic brain injury (TBI), and spinal cord injury. It may also aid treatment or prevention...
Published: 4/28/2020   |   Inventor(s): John Marshall, Dennis Goebel, Maik Huttemann
Category(s): Therapeutics
Optogenetic Control of the Blood Brain Barrier for Drug Delivery (Case 2135)
Principle Investigator:Christopher Moore, PhD, Associate Professor Department of NeuroscienceBrown UniversityBrief Description:The blood-brain-barrier (BBB) blocks approximately 98% of small molecule therapeutics and almost 100% of large molecular therapeutics from reaching the central nervous system, creating a challenge in drug delivery for treatment...
Published: 4/28/2020   |   Inventor(s): Christopher Moore, Tyler Brown
Category(s): Engineering and Sensors, Drug Delivery, Neuroscience, Oncology, Therapeutics
Minimally-Invasive and Activity Dependent Control of Excitable Neurons (Case 2333)
Principal Investigator:Christopher Moore, PhD, Associate ProfessorDepartment of NeuroscienceBrown UniversityProvidence, RIBrief Description:Abnormal cellular bursting is involved in a number of disease states. These include Parkinson’s Disease, affecting 1 million Americans and incurring an annual cost of $25 billion, and epilepsy, affecting 2...
Published: 3/30/2020   |   Inventor(s): Christopher Moore, Ute Hochgeschwender
Category(s): Neuroscience, Therapeutics
Compounds to Treat and Prevent Viral Infections (Case 2165)
Overview Polyomaviruses such as JC-polyomavirus (JCV) and BK-polyomavirus (BKV) are a common source of childhood and young adult infection. The majority of these infections cause little or no symptoms and are probably present in most adults. However, among people who are immunosuppressed as a result of AIDS, old age, or organ transplantation, these...
Published: 12/8/2014   |   Inventor(s): Walter Atwood, Jason Sello, Christian Nelson, Daniel Carney
Category(s): Therapeutics, Immunology and Vaccines
Micronized Hydrophobic Agents/Drugs for Superior Performance Medical and Otherwise (Case 1429)
Improvements to the Bioavailability of Hydrophobic Drugs Overview Hydrophobic agents are widely used in medicine, as well as in industry and agriculture, yet some hydrophobic agents have limited bioavailability by oral delivery. Our method of encapsulating hydrophobic agents uses a set of solvents and solutions to micronize the agent, giving it enhanced...
Published: 6/11/2012   |   Inventor(s): Edith Mathiowitz
Category(s): Therapeutics, Drug Delivery, Environmental, Nanotechnology
Novel, Versatile System for Progenitor Cell Recruitment in Tissue Repair/Regeneration (Case 1594)
Principal Investigator: Edith Mathiowitz, PhD, ProfessorDepartment of Bio Med Molecular Pharmacology, Physiology & Biotechnology Brown UniversityProvidence, RIBrief Description:Within the last decade, there is growing significant data on the therapeutic potential of endothelial progenitor cells (EPCs). EPCs present in bone marrow can be...
Published: 6/11/2012   |   Inventor(s): Edith Mathiowitz, Diana James (formerly Ferris)
Category(s): Drug Delivery, Nanotechnology, Stem Cells and Regenerative Medicine, Devices, Research Tools, Therapeutics
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