Search Results - Therapeutics

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Minimally-Invasive and Activity Dependent Control of Excitable Neurons (Case 2333)
Principal Investigator:Christopher Moore, PhD, Associate ProfessorDepartment of NeuroscienceBrown UniversityProvidence, RIBrief Description:Abnormal cellular bursting is involved in a number of disease states. These include Parkinson’s Disease, affecting 1 million Americans and incurring an annual cost of $25 billion, and epilepsy, affecting 2 million...
Published: 4/26/2017   |   Inventor(s): Christopher Moore, Ute Hochgeschwender
Category(s): Neuroscience, Therapeutics
Novel Therapeutic For Treating Brain Injury (Case 2118)
Principal Investigator:John Marshall, Ph.D.Professor of Medical ScienceBrown UniversityProvidence, RIBrief Description:The technology is a novel therapeutic for treating brain injuries, particularly those resulting from stroke, traumatic brain injury (TBI), and spinal cord injury (SCI). The technology has been tested in cell culture and rats, and preliminary...
Published: 4/26/2017   |   Inventor(s): John Marshall, Dennis Goebel, Maik Huttemann
Category(s): Therapeutics
Novel Antibiotic Targets – Conserved Nucleotide Elements in Ribosomal RNA (Case 2211) (EA)
Principal Investigator:Susan A. Gerbi, Ph.D, Professor of BiochemistryDepartment of Bio Med Molecular, Cellular Biology BiochemistryBrown University Providence, RI Brief Description:Antibiotic resistance is a current and increasing threat to public health. Antibiotic resistant bacterial infections are difficult or even impossible to treat with our current...
Published: 12/4/2015   |   Inventor(s): Susan Gerbi, Benjamin Raphael, Julia Beamesderfer, Stephen Doris, Deborah Smith
Category(s): Research Tools, Therapeutics
Treatment for Microcephaly-Associated Neurodevelopmental Disorders, Including Rare X-Linked Christianson’s Syndrome (Case 2192)
Principal Investigator:Eric Morrow, PhD, Associate ProfessorDepartment of Bio Med Molecular, Cellular Biology BiochemistryBrown UniversityProvidence, RIBrief Description:Intellectual and developmental disabilities (IDD) affect an estimated 4.6 million people in the US with annual costs in the range of $386BB. There are few bio-therapeutic options to...
Published: 11/24/2015   |   Inventor(s): Eric Morrow
Category(s): Neuroscience, Therapeutics
Optogenetic Control of the Blood Brain Barrier for Drug Delivery (Case 2135)
Principle Investigator:Christopher Moore, PhD, Associate Professor Department of NeuroscienceBrown UniversityBrief Description:The blood-brain-barrier (BBB) blocks approximately 98% of small molecule therapeutics and almost 100% of large molecular therapeutics from reaching the central nervous system, creating a challenge in drug delivery for treatment...
Published: 11/24/2015   |   Inventor(s): Christopher Moore, Tyler Brown
Category(s): Engineering and Sensors, Drug Delivery, Neuroscience, Oncology, Therapeutics
Applications of Acyldepsipeptide (ADEP) Fragments in Antibacterial Therapy (Case 2275)
Principal Investigator: Jason Sello, PhD, Associate ProfessorDepartment of ChemistryBrown UniversityProvidence, RIBrief Description:Acyldepsipeptide (ADEP) antibiotics hold promise as antibacterial drugs in this time of drug resistance and the urgent need for more therapeutic options.  ADEPs are molecules that act by binding to and activating the activity...
Published: 11/13/2015   |   Inventor(s): Jason Sello
Category(s): Therapeutics
Pain Management – Medical Device (Case RIH-136)
Principal Investigator:Carl Saab, PhD, Assistant ProfessorDepartment of Bio Med NeurosurgeryBrown UniversityProvidence, RIBrief Description:Chronic pain remains a daunting medical condition for growing numbers of patients worldwide whether it is associated with other disease conditions as a symptom or as a stand-alone syndrome.  Often treatments are...
Published: 3/13/2015   |   Inventor(s): Carl Saab
Category(s): Devices, Central Nervous System(CNS), Neuroscience, Therapeutics, Diagnostics
Unique 3D Biomimetic Nanosurfaces for Growing Cells and Producing Cellular Implants (Case 1696)
Principal Investigator:Diane Hoffman-Kim, PhD, Associate Professor    Department of Bio Med Molecular Pharmacology, Physiology and BiotechnologyBrown UniversityProvidence, RIBrief Description:An extensive list of polymers – natural and synthetic – has been utilized in drug delivery and in biomedical engineering for many years, especially in the formation...
Published: 2/6/2015   |   Inventor(s): Diane Hoffman-Kim
Category(s): Stem Cells and Regenerative Medicine, Devices, Drug Delivery, Nanotechnology, Research Tools, Therapeutics
Compounds for the Treatment and Prevention of Infections(EA) (Case 2165)
Principal Investigator:Walter Atwood, PhD, ProfessorDepartment of Bio Med Molecular & Cellular Biology BiochemistryBrown UniversityProvidence, RI Brief Description:Common Polyomaviruses can be severe and debilitating in immunocompromised patients with advanced age, HIV or an organ transplant are particularly susceptible.  No effective vaccines or targeted...
Published: 12/8/2014   |   Inventor(s): Walter Atwood, Jason Sello, Christian Nelson, Daniel Carney
Category(s): Therapeutics, Immunology and Vaccines
Targeted, Ferritin-based Molecular MR Imaging Probe for Cancer Detection and Treatment (EA) (Case 2129)
Principal Investigator: Edward Walsh, PhD, Assistant ProfessorDepartment of Bio Med Neuroscience & Diagnostic ImagingBrown UniversityProvidence, RIBrief Description:Lack of effective diagnosis and treatment of cancers such as colorectal, prostate, breast, lung, and liver cancer presents a great need for relevant technology.  The market urgently requires...
Published: 11/3/2014   |   Inventor(s): Edward Walsh, William Keun Chan Park, David Mills
Category(s): Diagnostics, Oncology, Therapeutics, Drug Delivery, Research Tools
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