Search Results - Therapeutics

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First in class use of the estrogen receptor-b agonist in treating Angelman syndrome and relevant autism spectrum disorders

Overview Angelman syndrome is a genetic disorder caused by UBE3A gene dysfunction, leading to cognitive impairment, motor coordination issues, and developmental delays. Research suggests that oligodendroglial dysfunction, which affects myelination in the brain, contributes to these conditions. Based on the research, this invention discloses a novel...

Published: 3/6/2025 | Inventor(s): Yu-Wen Huang, Xin Yang

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Category(s): Genetic Diseases, Therapeutics, Therapy Targets

Combining recombinant protein and fibrin spray to increase wound healing

Overview A little-appreciated complication of pneumonia in surgical patients is decreased wound healing. We have invented a treatment method that uses fibrin spray as a vehicle to topically deliver one or more chemokines to accelerate wound healing. Advantages of our method include effectiveness, ease of application, and the use of already-approved...

Published: 2/22/2024 | Inventor(s): Amanda Jamieson, Meredith Crane, Yun Xu

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Category(s): Therapeutics

Small-Molecule Inhibitors of the L-1 Endonuclease Domain

Overview Chronic inflammation is a hallmark of a number of age-related diseases, as well as of aging itself. Nuclear element-1 (L1) plays a key role in this inflammatory process. We have developed the first inhibitors of the L-1 endonuclease (EN) domain and the first of any retrotransposon-encoded EN. Our technology sheds light on the regulators that...

Published: 7/25/2023 | Inventor(s): John Sedivy, Gerwald Jogl, Alexandra D'Ordine

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Category(s): Therapeutics

Anti-Cancer Maleimide Derivatives for Use with Immune Checkpoint Blockade

Overview We have invented a cancer treatment that consists of administering an anti-cancer maleimide derivative together with an immune checkpoint blockade. Market Opportunity Globally, colorectal cancer (CRC) ranks third in incidence and second in mortality. The U.S. Food and Drug Administration recently approved the checkpoint inhibitors nivolumab...

Published: 6/7/2023 | Inventor(s): Wafik El-Deiry, Kelsey Huntington

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Category(s): Therapeutics, Oncology

Use of CRTH2 Antagonist to Treat Neuromyelitis Optica and Other Autoimmune Disorders of the Central Nervous System

Overview The detrimental effects of neuroinflammation, especially neuromyelitis optica spectrum disorder (NMOSD), on cognitive performance can include severe vision loss, motor deficits, and cognitive decline. We have invented a method that targets the detrimental effects of neuroinflammation on cognitive performance by using a CRTH2 (chemoattractant...

Published: 6/7/2023 | Inventor(s): Yu-Wen Huang, Changyong Tang, Wei Qiu, Yaxiong Cui

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Category(s): Central Nervous System(CNS), Therapeutics

Covid Prevention and Treatment Using an Integrin Inhibitor

Overview Although several highly effective vaccines against COVID-19 have been developed, the disease remains a threat to public health. We have invented a method of preventing or treating COVID-19 through administration of an integrin inhibitor such as GLPG-0187. Market Opportunity Although several highly effective vaccines against COVID-19 have...

Published: 6/7/2023 | Inventor(s): Wafik El-Deiry, Kelsey Huntington, Lindsey Carlsen, Olin Liang, Matthias Piesche

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Category(s): Therapeutics, Infectious Disease

L1 Inhibitor to Prevent Age-Associated Inflammation and Disease

Overview One hallmark of aging is the accumulation of senescent cells that contribute to sterile inflammation, which underlies many age-associated diseases such as osteoarthritis, cancer, and neurodegeneration. Nuclear element-1 (L1), which represents approximately 17% of the human genome, plays a key role in this process. We are identifying candidates...

Published: 1/21/2023 | Inventor(s): John Sedivy, Gerwald Jogl, Alexandra D'Ordine

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Category(s): Therapeutics

Anti-malarial drugs targeting PfGARP

Overview Plasmodium falciparum malaria is a leading cause of morbidity and mortality in developing countries, infecting hundreds of millions of individuals and killing more than 300,000 children each year. Certain parasite strains are resistant to all anti-malarial drugs, and the anti-malarial drug discovery pipeline is alarmingly limited. We have...

Published: 11/1/2022 | Inventor(s): Jonathan Kurtis, Andrew Oleinikov, Dipak Raj

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Category(s): Therapeutics

Inhibition of FTO with Entacapone to Treat Glioblastoma

Overview Glioblastoma is one of the most aggressive and lethal human tumors. We are investigating the use of an FDA-approved drug, Entacapone, to treat glioma tumors. Market Opportunity Glioblastoma, one of the most aggressive forms of cancer, has a survival rate of only 14–15 months after diagnosis. There is an urgent need for effective therapies...

Published: 10/15/2022 | Inventor(s): Nikolaos (Nikos) Tapinos, John Zepecki, David Karambizi

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Category(s): Oncology, Therapeutics

New use of CsA-type drugs for the prevention and treatment of neurodegenerative disorders, including Alzheimer’s disease

Novel Method Repurposes CsA-Type Compounds to Treat Neurodegenerative Disease Overview Alzheimer’s disease remains a challenging disorder for drug development, with many candidate drugs failing clinical trials. Our novel method repurposes camphorsulfonic acid (CsA)-type compounds to treat early-stage Alzheimer’s disease, as well as...

Published: 4/29/2022 | Inventor(s): Robbert Creton

Keywords(s):

Category(s): Therapeutics, Neurodegenerative Disease

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