Search Results - Neurodegenerative+Disease

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System for Closed-Loop Deep Brain Stimulation Using Neural and Behavioral Biomarkers of Specific Motor Features

System for Closed-Loop Deep Brain Stimulation Using Neural and Behavioral Biomarkers of Specific Motor Features Overview Parkinson’s Disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these different motor states could enable optimal closed-loop neuromodulation....

Published: 12/20/2024 | Inventor(s): Wael Asaad, Shane Lee, Umer Akbar, Peter Lauro

Keywords(s):

Category(s): Central Nervous System(CNS), Biomarker, Neurodegenerative Disease

A novel test to diagnose Normal Pressure Hydrocephalus (NPH) and predict shunt surgery benefit

A Novel Test to Diagnose Normal Pressure Hydrocephalus (NPH) and Predict Shunt Surgery Overview Normal pressure hydrocephalus (NPH) is a progressive neurological disorder characterized by the accumulation of cerebrospinal fluid (CSF) in the brain. NPH has devasting impacts on patient quality of life, including progressive neurodegeneration, locomotor...

Published: 11/25/2024 | Inventor(s): Alexander Fleischmann, Maria Ruocco, Petra Klinge, Thomas Serre

Keywords(s):

Category(s): Neurodegenerative Disease, Biomarker

Inhibition of the Egr2 promoter Antisense RNA with oligonucleotide GapmeRs as novel RNA therapy for human neuropathies

Overview Peripheral neuropathy can be caused by trauma, disease, or chemotherapy. We have developed sustained-release formulations that treat human neuropathies by prompting remyelination of the damaged nerves. The formulations are delivered by injection at the site of nerve damage, using a polymeric gel. Market Opportunity Peripheral nerve damage...

Published: 6/6/2024 | Inventor(s): Nikolaos (Nikos) Tapinos, David Karambizi, Margot Moreno

Keywords(s):

Category(s): Neurodegenerative Disease

Potential new targets for ALS

Overview Amyotrophic lateral sclerosis (ALS) is a devastating disease that is progressive, invariably fatal, and untreatable. Our invention features isolated Cyp4gl polypeptides with mutations at various key amino acid positions that suppress the effects and progress of ALS, as well as mutated polynucleotides that encode these polypeptides. Our invention...

Published: 10/19/2022 | Inventor(s): Robert Reenan, Yiannis Savva, Asli Sahin

Keywords(s):

Category(s): Therapy Targets, Neurodegenerative Disease

New use of CsA-type drugs for the prevention and treatment of neurodegenerative disorders, including Alzheimer’s disease

Novel Method Repurposes CsA-Type Compounds to Treat Neurodegenerative Disease Overview Alzheimer’s disease remains a challenging disorder for drug development, with many candidate drugs failing clinical trials. Our novel method repurposes camphorsulfonic acid (CsA)-type compounds to treat early-stage Alzheimer’s disease, as well as...

Published: 4/29/2022 | Inventor(s): Robbert Creton

Keywords(s):

Category(s): Therapeutics, Neurodegenerative Disease

A novel nucleocytoplasmic regulator of autophagy-associated transcription factors stimulates autophagy and prevents the proteostatic decline associated with neurodegeneration

Activating Autophagy to Prevent Neurodegeneration and Extend Lifespan Overview Decline in proteostasis is a hallmark of age-related neurodegerative disease such as Alzheimer’s Disease. Autophagy is the process by which cells rid themselves of damaged or otherwise unnecessary material, which then moves to the lysosome and degrades. Pharmacologic...

Published: 2/22/2022 | Inventor(s): Louis Lapierre

Keywords(s):

Category(s): Therapy Targets, Neurodegenerative Disease