Intra Cellular Delivery of Small Molecules Using Novel Nanotechnology (Case 2060)



Brown University
Providence, RI


Brief Description:


Pursuit of improved drug delivery vehicles continues to expand and grow with research focusing on a wide variety of approaches and necessary parameters, e.g., injectables, biocompatibility/degradability/availability, materials - polymers and nanoparticles -, water solubility, and toxicity, for anticancer and other drug delivery applications.  There are methods based on self-assembling molecules, as well as external stimuli to create amphiphilic polymers or lipid drug mixtures.  However, complex chemicals used to create existing drug carriers can reduce drug efficacy, while many simpler methods, exhibiting a fast, uneven release of hydrophobic drugs, limit prolonged drug-cell interactions.  Optimized complexes that deliver biologically active drugs and diagnostic agents, as a therapeutic or diagnostic, are needed.


This invention is a method to create self-assembling, rosette nanotubes bound to a plurality of bioactive/diagnostic agent(s) to form superior drug delivery carrier complexes, in situ, for therapeutic or diagnostic purposes.  The agent(s) may be bound to/on or encapsulated by the nanotubes depending on the delivery requirements and molecular/cellular target, and may be administered as such or in a pharmaceutical admixture.  This novel method produces biocompatible, safe, non-toxic, and highly stable nanotube-agent/drug complexes in water, suitable for hydrophobic drug incorporation, without the safety concerns of viral-related approaches.  Drug dosing can be more finely controlled, which may lower concentrations required for effective therapeutic use, and sustained drug release can be achieved.  These salient points represent advantages over conventional drug delivery systems.


The application is in the production of therapeutic and diagnostic delivery carriers, in human and veterinary medicine; the pharmaceutical market is indicated, and the market niches are drug delivery systems for therapeutic and diagnostic purposes.




US patent application 13/342,479 is pending

Patent Information:
For Information, Contact:
Margaret Shabashevich,
Manager of Operations
Office of Industry Engagement & Commercial Venturing
Brown University
Thomas Webster
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